Genetic association study between single nucleotide polymorphisms and cognitive performance in young bipolar I patients: Licavalgene

• Grant number: 10/06230-0
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2010
• End date: July 31, 2012
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Ricardo Alberto Moreno
• Grantee: Ricardo Alberto Moreno
• Host Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Carolina Martins Do Prado ; Danielle Soares Bio ; Elida Paula Benquique Ojopi ; Márcio Gerhardt Soeiro-de-Souza ; Wagner Farid Gattaz

Abstract

Cognition is a complex function influenced by a number of genes, each with a small role. The performance in each cognitive domain can be statistically associated to the activity of certain proteins and by that through genetic variations responsible for theses functional differences. The patients with bipolar disorder present serious dysfunctions during phases of mania, depression and mixed states. Nowadays we work with the hypothesis that exist a group of patients with similar genetic features that present a worse cognitive decline during the course of the illness. The genes most associated to cognitive function are catecol-o-metiltransferase, apolipoprotein E and brain derived neurotrophic protein. Our objective is to look for an association between cognitive performance and genotype of COMT, APOE and BDNF during the symptomatic phase of the disease. Methods: 80 symptomatic patients bipolar Type I, free of medication, age 18-35 years old and 60 healthy controls will go through complete cognite evaluation and genotyping for COMT, APOE and BDNF. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SOEIRO-DE-SOUZA, MARCIO GERHARDT; ANDREAZZA, ANA C.; CARVALHO, ANDRE F.; MACHADO-VIEIRA, RODRIGO; YOUNG, L. TREVOR; MORENO, RICARDO ALBERTO. Number of manic episodes is associated with elevated DNA oxidation in bipolar I disorder. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, v. 16, n. 7, p. 1505-1512, AUG 2013. (10/06230-0)

SOEIRO-DE-SOUZA, MARCIO GERHARDT; BIO, DANIELLE SOARES; DAVID, DENISE PETRESCO; MISSIO, GIOVANI; LIMA, BRUNO; FERNANDES, FERNANDO; MACHADO-VIEIRA, RODRIGO; MORENO, RICARDO ALBERTO. Gender effects of the COMT Val(158)Met genotype on verbal fluency in healthy adults. MOLECULAR MEDICINE REPORTS, v. 8, n. 3, p. 837-844, SEP 2013. (10/06230-0)

SOEIRO-DE-SOUZA, MARCIO GERHARDT; BIO, DANIELLE SOARES; DAVID, DENISE PETRESCO; DOS SANTOS, JR., DOMINGOS RODRIGUES; KERR, DANIEL SHIKANAI; GATTAZ, WAGNER FARID; MACHADO-VIEIRA, RODRIGO; MORENO, RICARDO ALBETO. COMT Met (158) modulates facial emotion recognition in bipolar I disorder mood episodes. Journal of Affective Disorders, v. 136, n. 3, p. 370-376, FEB 2012. (10/06230-0)

SOEIRO-DE-SOUZA, MARCIO GERHARDT; DIAS, VASCO VIDEIRA; BIO, DANIELLE SOARES; POST, ROBERT M.; MORENO, RICARDO A.. Creativity and executive function across manic, mixed and depressive episodes in bipolar I disorder. Journal of Affective Disorders, v. 135, n. 1-3, p. 292-297, DEC 2011. (10/06230-0)

SOEIRO-DE-SOUZA, MARCIO GERHARDT; MACHADO-VIEIRA, RODRIGO; BIO, DANIELLE SOARES; DO PRADO, CAROLINA MARTINS; MORENO, RICARDO ALBERTO. COMT polymorphisms as predictors of cognitive dysfunction during manic and mixed episodes in bipolar I disorder. BIPOLAR DISORDERS, v. 14, n. 5, p. 554-564, AUG 2012. (10/06230-0)