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Ribosomal gene expression of B-amyloid precursor protein, of presenilin and cytokines in brain and blood samples of Alzheimer's disease patients by Real Time PCR technique

Grant number: 09/15857-9
Support type:Regular Research Grants
Duration: May 01, 2010 - October 31, 2012
Field of knowledge:Biological Sciences - Genetics
Principal Investigator:Spencer Luiz Marques Payão
Grantee:Spencer Luiz Marques Payão
Home Institution: Faculdade de Medicina de Marília (FAMEMA). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). Marília , SP, Brazil

Abstract

Alzheimer's disease is a neurodegenerative, irreversible and progressive disorder that is characterized by cognition's decline, loss of memory and mental confusion. The etiology of this disease is complex and genetically heterogeneous. There is evidence that at least four different genetic loci can confer inherited susceptibility to Alzheimer's disease. Mutations in the amyloid precursor gene (APP) located in chromosome 21q21.1, in the chromosome 14q24.3, gene which encodes presenilin 1 (PS1) and in the Presenilin-2 gene (PS2) located in chromosome 1q42.1 can be associated with Alzheimer's disease. The allele e4 for apolipoprotein E gene (APOE) located in 19q13.2, associated with an increased risk for the development of AD. Our group have shown a decrease of ribosomal gene activity in Alzheimer's disease using blood samples. The present project will use brain samples and blood samples of Alzheimer's disease patients and controls and it has the follow objectives: to characterize the gene expression of ribosomal genes (28S and 18S), ABPP, PS1, PS2, interleukin 1beta e 8 by Real Time PCR; to verify the polymorphisms of the promoter 1beta e 8 genes. This is the original study in the literature to compare the expression of these genes simultaneously in Alzheimer's disease and can propose the new way for understanding this important disease. (AU)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FUKASAWA, JOSIANNE T.; DE LABIO, ROGER W.; RASMUSSEN, LUCAS T.; DE OLIVEIRA, LUCIENI C.; CHEN, ELIZABETH; VILLARES, JOAO; TURECK, GUSTAVO; SMITH, MARILIA DE ARRUDA C.; PAYAO, SPENCER L. M. CDK5 and MAPT Gene Expression in Alzheimer's Disease Brain Samples. Current Alzheimer Research, v. 15, n. 2, p. 182-186, 2018. Web of Science Citations: 2.
DA COSTA, ISABELA BAZZO; DE LABIO, ROGER WILLIAN; RASMUSSEN, LUCAS TREVIZANI; VIANI, GUSTAVO ARRUDA; CHEN, ELIZABETH; VILLARES, JOAO; TURECKI, GUSTAVO; CARDOSO SMITH, MARILIA DE ARRUDA; PAYAO, SPENCER L. M. Change in INSR, APBA2 and IDE Gene Expressions in Brains of Alzheimer's Disease Patients. Current Alzheimer Research, v. 14, n. 7, p. 760-765, 2017. Web of Science Citations: 4.
RASMUSSEN, LUCAS; DE LABIO, ROGER W.; VIANI, GUSTAVO A.; CHEN, ELIZABETH; VILLARES, JOAO; BERTOLUCCI, PAULO-HENRIQUE; MINETT, THAIS S.; TURECKI, GUSTAVO; CECYRE, DANIELLE; DRIGO, SANDRA A.; SMITH, MARILIA C.; PAYAO, SPENCER L. M. Differential Expression of Ribosomal Genes in Brain and Blood of Alzheimer's Disease Patients. Current Alzheimer Research, v. 12, n. 10, p. 984-989, 2015. Web of Science Citations: 3.
DELABIO, ROGER; RASMUSSEN, LUCAS; MIZUMOTO, IGOR; VIANI, GUSTAVO-ARRUDA; CHEN, ELIZABETH; VILLARES, JOAO; COSTA, ISABELA-BAZZO; TURECKI, GUSTAVO; LINDE, SANDRA APARECIDO; SMITH, MARILIA CARDOSO; PAYAO, SPENCER-LUIZ. PSEN1 and PSEN2 Gene Expression in Alzheimer's Disease Brain: A New Approach. JOURNAL OF ALZHEIMER'S DISEASE, v. 42, n. 3, p. 757-760, 2014. Web of Science Citations: 8.
RASMUSSEN, LUCAS; DELABIO, ROGER; HORIGUCHI, LIE; MIZUMOTO, IGOR; TERAZAKI, CARLOS-RENATO; MAZZOTTI, DIEGO; BERTOLUCCI, PAULO-HENRIQUE; PINHEL, MARCELA-AUGUSTA; SOUZA, DOROTEIA; KRIEGER, HENRIQUE; KAWAMATA, CARLOS; MINETT, THAIS; SMITH, MARILIA CARDOSO; PAYAO, SPENCER-LUIZ. Association Between Interleukin 6 Gene Haplotype and Alzheimer's Disease: A Brazilian Case-Control Study. JOURNAL OF ALZHEIMER'S DISEASE, v. 36, n. 4, p. 733-738, 2013. Web of Science Citations: 10.
MARQUES PAYAO, SPENCER LUIZ; GONCALVES, GISELA MORAES; DE LABIO, ROGER WILLIAM; HORIGUCHI, LIE; MIZUMOTO, IGOR; RASMUSSEN, LUCAS TREVIZANI; DE SOUZA PINHEL, MARCELA AUGUSTA; SILVA SOUZA, DOROTEIA ROSSI; BECHARA, MARCELO DIB; CHEN, ELIZABETH; MAZZOTTI, DIEGO ROBLES; FERREIRA BERTOLUCCI, PAULO HENRIQUE; CARDOSO SMITH, MARILIA DE ARRUDA. Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease. Journal of Neuroimmunology, v. 247, n. 1-2, p. 59-62, JUN 15 2012. Web of Science Citations: 17.

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