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Leishmanicidal principles of vegetable species from Atlantic Forest: evaluation, isolation and molecular characterization

Grant number: 08/11496-9
Support type:Regular Research Grants
Duration: May 01, 2009 - January 31, 2012
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Patricia Sartorelli
Grantee:Patricia Sartorelli
Home Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil


The present work aiming to evaluate the therapeutically potential of medicinal plants extracts from Atlantic forest in the treatment of visceral and tegumentar leishmaniosis. In this way, several crude extracts, fractions, and pure compounds obtained from vegetal species of Atlantic forest against promastigotes and amastigostes forms of Leishmania chagasi e L. amazonensis using in vitro assays, based in ethnopharmacological information. Additionally, the inhibitory capacity of the hydrolytic activity from cysteine-proteases obtained from parasite forms of cellular extracts and their respectively cytoxicity will be evaluated, using in vitro assays. The isolation and molecular characterization of the active compounds will be conducing using several chromatographic and spectrometric steps. This phytochemical analysis will be bioguided using the assays employed to detect the anti-Leishmanial activity. Aiming to evaluate the pharmacophorical groups in the structure of the active compounds, these will be submitted to the several structural modifications. Therefore, the present project will include new compounds containing anti-Leishmanial potential to the therapeutically use of natural products in the development of new compounds to this important parasitosis. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Plant from Brazil contains a compound with an anti-inflammatory action 

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GRECCO, SIMONE DOS S.; REIMAO, JULIANA Q.; TEMPONE, ANDRE G.; SARTORELLI, PATRICIA; CUNHA, RODRIGO L. O. R.; ROMOFF, PAULETE; FERREIRA, MARCELO J. P.; FAVERO, ORIANA A.; LAGO, JOAO HENRIQUE G. In vitro antileishmanial and antitrypanosomal activities of flavanones from Baccharis retusa DC. (Asteraceae). Experimental Parasitology, v. 130, n. 2, p. 141-145, FEB 2012. Web of Science Citations: 46.
MORAIS, THIAGO R.; ROMOFF, PAULETE; FAVERO, ORIANA A.; REIMAO, JULIANA Q.; LOURENCO, WALKYRIA C.; TEMPONE, ANDRE G.; HRISTOV, ANGELICA D.; DI SANTI, SILVIA M.; LAGO, JOAO HENRIQUE G.; SARTORELLI, PATRICIA; FERREIRA, MARCELO J. P. Anti-malarial, anti-trypanosomal, and anti-leishmanial activities of jacaranone isolated from Pentacalia desiderabilis (Vell.) Cuatrec. (Asteraceae). Parasitology Research, v. 110, n. 1, p. 95-101, JAN 2012. Web of Science Citations: 19.
LAGO, JOAO HENRIQUE G.; SOUZA, ELISANGELA DUTRA; MARIANE, BRUNA; PASCON, RENATA; VALLIM, MARCELO A.; MARTINS, ROBERTO CARLOS C.; BAROLI, ADRIANA A.; CARVALHO, BIANCA A.; SOARES, MARISI G.; DOS SANTOS, ROBERTA T.; SARTORELLI, PATRICIA. Chemical and Biological Evaluation of Essential Oils from Two Species of Myrtaceae - Eugenia uniflora L. and Plinia trunciflora (O. Berg) Kausel. Molecules, v. 16, n. 12, p. 9827-9837, DEC 2011. Web of Science Citations: 25.
SARTORELLI, PATRICIA; CARVALHO, CAMILA SALOMONE; REIMAO, JULIANA QUERO; LORENZI, HARRI; TEMPONE, ANDRE GUSTAVO. Antitrypanosomal Activity of a Diterpene and Lignans Isolated from Aristolochia cymbifera. Planta Medica, v. 76, n. 13, p. 1454-1456, SEP 2010. Web of Science Citations: 20.

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