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Effect of a PDT protocol with multiple aplications as an adjuvant on the non surgical treatment of periodontal disease in patients with type 2 diabetes: a clinical and laboratorial study in humans

Grant number: 10/07326-0
Support Opportunities:Regular Research Grants
Duration: October 01, 2010 - October 31, 2013
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Marcio Fernando de Moraes Grisi
Grantee:Marcio Fernando de Moraes Grisi
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The objective of the study is to evaluate Photodynamic Therapy (PDT) as adjuvant on non-surgical periodontal therapy in patients with type 2 diabetes. A total of 40 individuals will be selected and divided randomically in two groups. On the treatment stage, the control group (Group C) will receive standard non-surgical periodontal treatment. The Test Group (Group T) will be treated with PDT as an adjuvant to non-surgical periodontal treatment. The treatment will be repeated 4 times weekly, followed by dental profilaxy every 15 days until acomplish 3 months. The follo-up will be done for 6 months. The clinical parametersmeasured will be: plaque índex, pocket depht, bleeding on probing, relative clinical insertion level and supuration. In addition, the evaluation of crevicular fluid volume and the levels of IL-1, TNF-±, subgengival microbiote by the hibridization DNA-DNA Checkerboard technique. All data will be submited for statiscal analisys. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RAMOS, UMBERTO D.; AYUB, LAURO G.; REINO, DANILO M.; GRISI, MARCIO F. M.; TABA, JR., MARIO; SOUZA, SERGIO L. S.; PALIOTO, DANIELA B.; NOVAES, JR., ARTHUR B.. Antimicrobial photodynamic therapy as an alternative to systemic antibiotics: results from a double-blind, randomized, placebo-controlled, clinical study on type 2 diabetics. Journal of Clinical Periodontology, v. 43, n. 2, p. 147-155, . (10/07326-0)
RAMOS, UMBERTO D.; AYUB, LAURO G.; REINO, DANILO M.; GRISI, MARCIO F. M.; TABA, MARIO, JR.; SOUZA, SERGIO L. S.; PALIOTO, DANIELA B.; NOVAES, ARTHUR B., JR.. Antimicrobial photodynamic therapy as an alternative to systemic antibiotics: results from a double-blind, randomized, placebo-controlled, clinical study on type 2 diabetics. JOURNAL OF CLINICAL PERIODONTOLOGY, v. 43, n. 2, p. 9-pg., . (10/07326-0)

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