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The effect of freeze-dried peel jabuticaba, conjugated linoleic acid (CLA) and phytosterols on the prevention and treatment of high fat diet-induced obesity using different experimental models

Grant number: 10/05262-5
Support Opportunities:Regular Research Grants
Duration: September 01, 2010 - August 31, 2012
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Mário Roberto Maróstica Junior
Grantee:Mário Roberto Maróstica Junior
Host Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated researchers: Anne Y Castro Marques ; Dennys Esper Corrêa Cintra ; Nathalia Romanelli Vicente Dragano ; Rafaela da Silva Marineli ; Sabrina Alves Lenquiste


Rapid changes in diets and lifestyles due to economic development and market globalization have accelerated over the past decade. This resulted in a significant impact on the health and nutritional status of populations. Obesity, a chronic non-communicable disease, is currently a worldwide pandemic and it is increasing significantly, causing disability and premature death in both developing and newly developed countries. This study aims to investigate the action of jabuticaba peel (rich in anthocyanins), conjugated linoleic acid (CLA) and phytosterols on the molecular and physiological mechanisms, prevention and treatment of obesity in vivo. Four biological assays will be conducted; two of them using the freeze-dried peel jabuticaba and two experiments using lipid sources (CLA and phytosterols) as supplements. Two experiments will assess the effects of the freeze-dried peel jabuticaba, CLA and / or phytosterols in weight gain, lipids and hormones profile, insulin resistance and modulation of gene expression in mice fed high-fat diet, and two other experiments will evaluate weight gain, hormonal and lipid profile, insulin resistance and lipid peroxidation in rats, fed diets high in fat. The results will be submitted to analysis of variance (ANOVA) and treatment means will be compared by Tukey test (alpha = 0.05). The project will run between the second half of 2010 and the first half of 2013. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LAMAS, C. A.; KIDO, L. A.; MONTICO, F.; COLLARES-BUZATO, C. B.; MAROSTICA, JR., M. R.; CAGNON, V. H. A.. A jaboticaba extract prevents prostatic damage associated with aging and high-fat diet intake. FOOD & FUNCTION, v. 11, n. 2, p. 1547-1559, . (15/50333-1, 15/25714-1, 10/05262-5)
BATISTA, ANGELA G.; SOARES, EDILENE S.; MENDONCA, MONIQUE C. P.; DA SILVA, JULIANA K.; DIONISIO, ANA PAULA; SARTORI, CESAR R.; DA CRUZ-HOFLING, MARIA ALICE; MAROSTICA JUNIOR, MARIO R.. Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice. MOLECULAR NUTRITION & FOOD RESEARCH, v. 61, n. 10, . (15/50333-1, 10/05262-5)

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Filed patent(s) as a result of this research project

COMPOSIÇÃO COMPREENDENDO EXTRATO DA CASCA DE JABUTICABA, E USOS DO MESMA BR1020170054624 - Universidade Estadual de Campinas (UNICAMP) . Mário Roberto Marostica Junior; Valéria H. Alves Cagnon Quitete; Celina De Almeida Lamas; Sabrina Alves Lenquiste; Felix Guillermo Reyes Reyes; Patricia Aparecida De Campos Braga; Andressa Mara Baseggio - March 2017, 17

COMPOSIÇÃO COMPREENDENDO EXTRATO DA CASCA DE JABUTICABA E USOS DA MESMA PCT/BR2018/000011 - Universidade Estadual de Campinas (UNICAMP) . Mário Roberto Marostica Junior ; Valéria H. Alves Cagnon Quitete ; Celina de Almeida Lamas ; Sabrina Alves Lenquiste ; Felix Guillermo Reyes Reyes ; Patricia Aparecida Campos Braga ; Andres Mara Basseggio - March 2018, 07