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Diversity of HPV types in the male genital region

Grant number: 10/15282-3
Support type:Regular Research Grants
Duration: November 01, 2010 - April 30, 2013
Field of knowledge:Biological Sciences - Biochemistry - Biochemistry of Microorganisms
Principal Investigator:Laura Cristina Sichero Vettorazzo
Grantee:Laura Cristina Sichero Vettorazzo
Home Institution: Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Assoc. researchers:Luisa Lina Villa


HPV is mainly transmitted by sexual contact and infection by these viruses are strongly associated to the development of cancer from the cervix, vulva and anus in women, penis and anal cancer in men, and head and neck cancer in both genders. Case-control studies conducted in women with cervical cancer showed that male partner sexual behavior influences the risk of women of developing this neoplasia. However little is known about the natural history of penile HPV infection in men. Since 2005 a prospective international (Brazil, Mexico, United States) study in men is being conducted, the HPV in Men Study (HIM) in which about 4.000 men are being followed every 6 months for a period of 4 years. For the genotyping of these samples, a methodology capable of identifying 37 HPV types commonly detected among women genital specimens is being used. Initial analysis of the HIM study included 1.160 men enrolled from March 2005 to December 2006. In this group HPV genital prevalence was 65,2%, of which 14,7% comprised non classified infections. Along this cohort study 1.000 specimens of unclassified HPV were identified. In order to better understand the significance of these viral types in the natural history of HPV infection, it is crucial to characterize these samples. Our aim is: (1) Identify HPV types infecting samples from the HIM study characterized as unclassified; (2) Determine the frequency of individual HPV types detected among these specimens; and (3) Identify factors independently associated with the acquisition, persistence and clearance of these HPV types in men. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SICHERO, L.; NYITRAY, A. G.; NUNES, E. M.; NEPAL, B.; FERREIRA, S.; SOBRINHO, J. S.; BAGGIO, M. L.; GALAN, L.; SILVA, R. C.; LAZCANO-PONCE, E.; GIULIANO, A. R.; VILLA, L. L.; GRP, HIM STUDY. Diversity of human papillomavirus in the anal canal of men: the HIM Study. Clinical Microbiology and Infection, v. 21, n. 5, p. 502-509, MAY 2015. Web of Science Citations: 10.
SICHERO, LAURA; CAMPBELL, CHRISTINE M. PIERCE; FULP, WILLIAM; FERREIRA, SILVANEIDE; SOBRINHO, JOAO S.; BAGGIO, MARIA LUIZA; GALAN, LENICE; SILVA, ROBERTO C.; LAZCANO-PONCE, EDUARDO; GIULIANO, ANNA R.; VILLA, LUISA L.; GRP, HIM STUDY. High genital prevalence of cutaneous human papillomavirus DNA on male genital skin: the HPV Infection in Men Study. BMC INFECTIOUS DISEASES, v. 14, DEC 9 2014. Web of Science Citations: 15.
SICHERO, LAURA; CAMPBELL, CHRISTINE M. PIERCE; FERREIRA, SILVANEIDE; SOBRINHO, JOAO S.; BAGGIO, MARIA LUIZA; GALAN, LENICE; SILVA, ROBERTO C.; LAZCANO-PONCE, EDUARDO; GIULIANO, ANNA R.; VILLA, LUISA L.; GRP, HIM STUDY. Broad HPV distribution in the genital region of men from the HPV infection in men (HIM) study. VIROLOGY, v. 443, n. 2, p. 214-217, SEP 1 2013. Web of Science Citations: 27.

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