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Comparison between tuberculin skin test (TST) and interferon gama release assay (IGRA) in the diagnosis of latent tuberculosis in hematopoietic stem cell transplant recipients (HSCT)

Grant number: 10/08816-1
Support Opportunities:Regular Research Grants
Duration: November 01, 2010 - October 31, 2012
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal Investigator:Clarisse Martins Machado
Grantee:Clarisse Martins Machado
Host Institution: Hospital Amaral Carvalho (HAC). Fundação Amaral Carvalho (FAC). Jaú , SP, Brazil


The main risk factor for the development of tuberculosis in HSCT recipients is to live in region of high endemicity. Brazil has high prevalence rates of TB with an incidence of 38.2 per 100,000 in habitants per year. Post-transplant immunosuppression favors the reactivation of latent TB and therefore, a higher incidence of tuberculosis is expected in this group of patients in comparison to general population. The PPD test has limitations in the diagnosis of latent TB in immunocompromised patients and the interferon gamma release assay (IGRA) may be helpful in this setting. No study has been conducted in HSCT recipients, comparing both tests in the diagnosis of latent TB. Similarly, there isn't any prospective study evaluating the incidence, morbidity and mortality of TB in HSCT recipients. The present study aims to compare TST and IFN gamma detection in the diagnosis of latent TB as well as to determine the disease incidence in a cohort of HSCT recipients. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA RODRIGUES, MARINA; DE ALMEIDA TESTA, LUCIA H.; DOS SANTOS, ANA CLAUDIA F.; ZANETTI, LILIAN P.; DA SILVA RUIZ, LUCIANA; DE SOUZA, MAIR PEDRO; COLTURATO, VERGILIO R.; MACHADO, CLARISSE M.. Latent and active tuberculosis infection in allogeneic hematopoietic stem cell transplant recipients: a prospective cohort study. BONE MARROW TRANSPLANTATION, v. 56, n. 9, p. 2241-2247, . (10/08816-1)

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