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Center for Research on Cell-Based Therapy

Grant number: 98/14247-6
Support type:Research Grants - Research, Innovation and Dissemination Centers - RIDC
Duration: October 01, 2000 - December 31, 2012
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Marco Antonio Zago
Grantee:Marco Antonio Zago
Home Institution: Hemocentro de Ribeirão Preto. Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (HCMRP). Secretaria da Saúde (São Paulo - Estado). Ribeirão Preto , SP, Brazil
Co-Principal Investigators:Dimas Tadeu Covas ; Eduardo Magalhães Rego ; Júlio César Voltarelli ; Lewis Joel Greene ; Roberto Passetto Falcão ; Roger Chammas ; Wilson Araújo da Silva Junior
Associated grant(s):07/50232-4 - Grafting of jararhagin trkkhdnaq sequence within desintegrin viperistatin framework supports binding to aplha 2 beta 1 integrin, AR.EXT
06/52100-5 - New pathways involved inapoptosis inhibiton in chronic lymphocytic leukemia, AR.EXT
Associated scholarship(s):11/11456-0 - Molecular basis analysis of Rett Syndrome pacients treated at the Hospital das Clínicas da Faculdade de Medicina de ribeirão Preto/USP, BP.IC
10/15825-7 - Viscoelastic ultrasound images of tissues by tracking the movement of magnetic nanoparticles, BP.PD
10/02074-3 - Therapeutic potential of DPP-4 inhibitor and mesenchymal stromal cells administration in experimental streptozotocin-induced type 1 diabetes mellitus, BP.MS
+ associated scholarships 09/10857-0 - Evaluation of the mechanism of anti-apoptotic effect of galectin-3 in glioma cells and its role in the development of pseudopalisades in vivo, BP.DR
08/11505-8 - Evaluation of prohibitin participation in the four main pathways of melanoma development, BP.DR
08/11513-0 - Evaluation of galectin-3 role in the adaptative process of tumor cells in response of inflammatory immune response and chemotherapeutic selective pressures in the tumoral microenvironment, BP.PD
08/02164-2 - Interface between aberrant glicosylation of tumors and the unfolded protein response: target for chemosensitization in melanomas?, BP.MS
07/07037-6 - Evaluation of the involvement of the innate immune response mediated by TLR2 and TLR4 in the therapeutic response to dacarbazine in melanoma murine model, BP.PD
08/00247-8 - Cytometric assessment of the murine melanoma microenvironment in the course of experimental chemotherapy: analysis of inflammatory infiltrate and kinetics of tumor cell repopulation, BP.IC
08/51503-4 - Analysis of C/EBP role in leukemogenesis induced by the hybrid protein CALM/AF10, BP.PD
07/05975-9 - Activation of the endoplasmic reticulum stress pathway as a potential chemosensitizing agent in cisplatin-induced cell death, BP.MS
04/06892-1 - Center for Research on Cell-Based Therapy, BP.TT
02/02906-2 - Determination of EEL structure, an elongation factor of the enzyme RNA polymerase II, frequently present in MLL gene translocations in cases of acute myeloid leukemia, BP.PD
01/04492-8 - Cancer immunotherapy: the indolent B-cell malignancies as a tumor model, BE.PQ - associated scholarships

Abstract

Description of the Center and its characteristic features. The Center is composed of researchers in the fields of human cytology, molecular and population, genetics, immunology, protein chemistry, cell culture, blood coagulation, transplantation biology, transfusion medicine and hematology, who have collaborated in different associations in the past and work in three closely located facilities in the University of S. Paulo, campus of Ribeirao Preto: 1. Regional Blood Center and Biocenter; 2. Hematology Laboratories, Bone Marrow Transplant Unit and Hematology Wards at the University Hospital; 3. Protein Chemistry Laboratory. All researchers share an interest in the cellular and molecular aspects of the blood tissue, its function, diseases and therapeutics, and now propose to join efforts to answer questions related to the use of cells to treat human diseases, especially hematological diseases. Most of the researchers of the center are already using cells to treat human diseases (transfusions, allogeneic and autologous transplantation) or are studying features of these cells, of the donors and of the recipients, which may have a bearing on the evolution of the disease or the effect of treatment. b) Definition of research focus and of its multidisciplinary connections. The research focus is cell therapy for treatment of diseases; this includes allogeneic bone marrow transplantation, therapy with autologous stem cells obtained from peripheral blood, and novel approaches such as the use of umbilical cord blood. The cells can be transplanted immediately after collection, or they can be processed and cryopreserved for long periods. There is great interest in further processing of these cells, such as purging the neoplastic cells, 'ex vivo' expansion and gene transfer for gene therapy. The initial research program includes evaluation of immunologic, structural and genetic characteristics of transplantable hematopoietic stem cells from different sources, cell-to-cell interactions and signaling, the setting up of a cord cell bank and evaluation of properties of cord blood stem cells, especially after 'ex vivo' expansion, the genetic manipulation of cells, the evaluation of some disease characteristics of the recipients, and the setting up of animal models for the study of the diseases and transplant treatment. c) Description of planned technology transfer and educational activities and of their relationship to the research focus. The Regional Blood Center is a facility with an independent administration jointly supported by the university, the university hospital and the state Department of Health; since its establishment in 1985 it gradually took over the direct processing and supervision of blood collection and distribution of blood components in a region containing 4.2 million inhabitants (167 municipalities), the training of specialists and technicians, and the definition of public policies in the area of blood transfusion. Three of the principal researchers who participate in the Center have had previous experience with the transfer of research results to the biotechnology industry or have applied for patents in this area. The planned technology transfer will include: 1. Creation and operation of a cord cell blood bank; 2. Development of new diagnostic approaches to diseases related to the treatment of blood-derived products (for instance, AIDS and Chagas disease); 3. Investigation of critical aspects of therapy with blood or cell products, which may be transferred to the health authorities and serve as the basis of public policies in this area; 4. The transfer of modern know-how in cell therapy by training of medical personnel (medical doctors, nurses and technicians). Educational activities will include: 1. A long-term joint program with the regional branches of the state and the city Departments of Education for high-school teachers and students has been negotiated. The program includes continuing education classes for teachers, short courses in specific subjects for students, and the development of introductory research projects in the laboratories of the Center and in the school laboratories for a number of selected high-school students and teachers, the results of which will be presented in mini-congresses. The subjects for this program are cytology, genetics, immunology. biochemistry and health education. 2. The collaboration with high school teachers for the development of educational resources (virtual museums and libraries, films, printed material, CD for personal computers). 3. Training of biologists, pharmacists, nurses and technicians in the laboratory methods involved in cell collection, processing and cryopreservation, donor selection, the clinical support of donors and recipients, laboratory methods for cell separation and culture, the immunologic, genetic and biochemical strategies of research. 4. Introductory research programs for at least 10 medical students a year. 5. Training of residents and graduate students (MSc and DSc) as part of the university's graduate program. d) Brief justification for the creation of a research center. To study at least part of the phenomena involved in cell-based therapy it is necessary to combine efforts of medical doctors doing clinical research in hematology and stem cell transplantation with those of basic researchers in the fields of cytology, cell separation and culture, immunology, molecular genetics, and protein chemistry. Adequate clinical facilities, laboratories for basic work and facilities for cell collection, processing and storing are also necessary. The center includes researchers and technicians who are trained (or in training) for the use of all the proposed methods, the researchers have worked together in small groups, there are considerable resources already available (buildings, scientific equipment, administrative support), the researchers have interactions with other relevant groups in the field, and they carry out both clinical work and basic research in the same environment. e) Description of facilities offered as counterpart by the participating Institutions. Physical installations of the Center include the Regional Blood Center (2200 m2 of laboratories + 1800 m2 administrative and educational area) and the adjacent Biocenter (4000 m2 laboratories, in final phases of construction) which are located 300 m from the University Hospital which contains the Hematology Laboratories (300 m2) and Wards (11 beds), and a Bone Marrow Transplant Unit (5 especially isolated rooms); the Protein Chemistry Laboratory (300 m2, will be transferred to the Biocenter in a 500 m2 area). Personnel: 8 principal researchers (salaries paid by the university or the Regional Blood Center); 33 medical doctors or biologists/technicians (salaries paid by the university, the university hospital or the Regional Blood Center); 17 biologists, technicians or medical students in training (scholarships paid by the Regional Blood Center). Large equipment already in place (3 Facs-sorters, 2 automatic DNA-sequencers, 2 automatic amino acid-analyzers, 1 ESI MS/MS mass spectrometer, 1 automatic protein sequencer, 1 capillary HPLC, 1 preparative ultracentrifuge, 5 thermocyclers for PCR, 2 nitrogen-freezers for storing cryopreserved cells, 3 apheresis instruments for obtaining peripheral blood cells from patients, 1 Electra ML1600 coagulometer, facilities for cell culture). The Regional Blood Center is presently implementing an IS09002 quality program. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Study changes policy for treatment of systemic sclerosis 

Scientific publications (40)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LUCENA-ARAUJO, ANTONIO R.; COELHO-SILVA, JUAN L.; PEREIRA-MARTINS, DIEGO A.; SILVEIRA, DOUGLAS R.; KOURY, LUISA C.; MELO, RAUL A. M.; BITTENCOURT, ROSANE; PAGNANO, KATIA; PASQUINI, RICARDO; NUNES, ELENAIDE C.; FAGUNDES, EVANDRO M.; GLORIA, ANA B.; KERBAUY, FABIO; CHAUFFAILLE, MARIA DE LOURDES; BENDIT, ISRAEL; ROCHA, VANDERSON; KEATING, ARMAND; TALLMAN, MARTIN S.; RIBEIRO, RAUL C.; DILLON, RICHARD; GANSER, ARNOLD; LOWENBERG, BOB; VALK, P. J. M.; LO-COCO, FRANCESCO; SANZ, MIGUEL A.; BERLINER, NANCY; REGO, EDUARDO M. Combining gene mutation with gene expression analysis improves outcome prediction in acute promyelocytic leukemia. Blood, v. 132, n. 12, p. 951-959, SEP 19 2019. Web of Science Citations: 1.
OTAKE, ANDREIA HANADA; SAITO, RENATA DE FREITAS; MARQUES DUARTE, ANA PAULA; RAMOS, ALEXANDRE FERREIRA; CHAMMAS, ROGER. G(D3) ganglioside-enriched extracellular vesicles stimulate melanocyte migration. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v. 1864, n. 3, p. 422-432, MAR 2019. Web of Science Citations: 1.
RAMOS CIRILO, PRISCILA DANIELE; DE SOUSA ANDRADE, LUCIANA NOGUEIRA; SILVA CORREA, BRUNA RENATA; QIAO, MEI; FURUYA, TATIANE KATSUE; CHAMMAS, ROGER; FERRAZ PENALVA, LUIZ OTAVIO. MicroRNA-195 acts as an anti-proliferative miRNA in human melanoma cells by targeting Prohibitin 1. BMC CANCER, v. 17, NOV 10 2017. Web of Science Citations: 12.
TORTELLI JUNIOR, THARCISIO CITRANGULO; FRANCO DE GODOY, LYRIS MARTINS; DE SOUZA, GUSTAVO ANTONIO; BONATTO, DIEGO; OTAKE, ANDREIA HANADA; SAITO, RENATA DE FREITAS; ROSA, JOSE CESAR; GREENE, LEWIS JOEL; CHAMMAS, ROGER. Accumulation of prohibitin is a common cellular response to different stressing stimuli and protects melanoma cells from ER stress and chemotherapy-induced cell death. ONCOTARGET, v. 8, n. 26, p. 43114-43129, JUN 27 2017. Web of Science Citations: 13.
DE AGUIAR, RODRIGO BARBOSA; PARISE, CAROLINA BELLINI; TEIXEIRA SOUZA, CAROLINA ROSAL; BRAGGION, CAMILA; QUINTILIO, WAGNER; MORO, ANA MARIA; NAVARRO MARQUES, FABIO LUIZ; BUCHPIGUEL, CARLOS ALBERTO; CHAMMAS, ROGER; DE MORAES, JANE ZVEITER. Blocking FGF2 with a new specific monoclonal antibody impairs angiogenesis and experimental metastatic melanoma, suggesting a potential role in adjuvant settings. Cancer Letters, v. 371, n. 2, p. 151-160, 2016. Web of Science Citations: 9.
SANZ, MIGUEL A.; MONTESINOS, PAU; KIM, HAESOOK T.; RUIZ-ARGUEELLES, GUILLERMO J.; UNDURRAGA, MARIA S.; URIARTE, MARIA R.; MARTINEZ, LEM; JACOMO, RAFAEL H.; GUTIERREZ-AGUIRRE, HOMERO; MELO, RAUL A. M.; BITTENCOURT, ROSANE; PASQUINI, RICARDO; PAGNANO, KATIA; FAGUNDES, EVANDRO M.; VELLENGA, EDO; HOLOWIECKA, ALEXANDRA; GONZALEZ-HUERTA, ANA J.; FERNANDEZ, PASCUAL; DE LA SERNA, JAVIER; BRUNET, SALUT; DE LISA, ELENA; GONZALEZ-CAMPOS, JOSE; RIBERA, JOSE M.; KRSNIK, ISABEL; GANSER, ARNOLD; BERLINER, NANCY; RIBEIRO, RAUL C.; LO-COCO, FRANCESCO; LOWENBERG, BOB; REGO, EDUARDO M.; GRP, IC-APL; GRP, PETHEMA; GRP, HOVON. All-trans retinoic acid with daunorubicin or idarubicin for risk-adapted treatment of acute promyelocytic leukaemia: a matched-pair analysis of the PETHEMA LPA-2005 and IC-APL studies. ANNALS OF HEMATOLOGY, v. 94, n. 8, p. 1347-1356, AUG 2015. Web of Science Citations: 8.
CASTILHO-FERNANDES, ANDRIELLE; FONTES, APARECIDA MARIA; ABRAHAM, KURUVILLA JOSEPH; CORREA DE FREITAS, MARCELA CRISTINA; DA ROSA, NATHALIA GONSALES; PICANCO-CASTRO, VIRGINIA; DE SOUSA RUSSO-CARBOLANTE, ELISA MARIA; COVAS, DIMAS TADEU. Significant differences in integration sites of Moloney murine leukemia virus/Moloney murine sarcoma virus retroviral vector carrying recombinant coagulation factor IX in two human cell lines. Biotechnology Letters, v. 37, n. 5, p. 991-1001, MAY 2015. Web of Science Citations: 0.
LUCENA-ARAUJO, ANTONIO R.; KIM, HAESOOK T.; JACOMO, RAFAEL H.; MELO, RAUL A.; BITTENCOURT, ROSANE; PASQUINI, RICARDO; PAGNANO, KATIA; FAGUNDES, EVANDRO M.; CHAUFFAILLE, MARIA DE LOURDES; CHIATTONE, CARLOS S.; LIMA, ANA SILVIA; RUIZ-ARGUEELLES, GUILLERMO; SOLEDAD UNDURRAGA, MARIA; MARTINEZ, LEM; KWAAN, HAU C.; GALLAGHER, ROBERT; NIEMEYER, CHARLOTTE M.; SCHRIER, STANLEY L.; TALLMAN, MARTIN S.; GRIMWADE, DAVID; GANSER, ARNOLD; BERLINER, NANCY; RIBEIRO, RAUL C.; LO-COCO, FRANCESCO; LOWENBERG, BOB; SANZ, MIGUEL A.; REGO, EDUARDO M. Internal tandem duplication of the FLT3 gene confers poor overall survival in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukemia study. ANNALS OF HEMATOLOGY, v. 93, n. 12, p. 2001-2010, DEC 2014. Web of Science Citations: 14.
IKEMORI, RAFAEL YAMASHITA; LONGO MACHADO, CAMILA MARIA; FURUZAWA, KARINA MIE; NONOGAKI, SUELY; OSINAGA, EDUARDO; UMEZAWA, KAZUO; DE CARVALHO, MARCELO ALEX; VERINAUD, LIANA; CHAMMAS, ROGER. Galectin-3 Up-Regulation in Hypoxic and Nutrient Deprived Microenvironments Promotes Cell Survival. PLoS One, v. 9, n. 11 NOV 4 2014. Web of Science Citations: 21.
BACCHI, PEDRO STARZYNSKI; BLOISE, ANTONIO CARLOS; BUSTOS, SILVINA ODETE; ZIMMERMANN, LARA; CHAMMAS, ROGER; RABBANI, SAID RAHNAMAYE. Metabolism under hypoxia in Tm1 murine melanoma cells is affected by the presence of galectin-3, a metabolomics approach. SPRINGERPLUS, v. 3, AUG 26 2014. Web of Science Citations: 1.
LONGO MACHADO, CAMILA MARIA; SOUSA ANDRADE, LUCIANA NOGUEIRA; TEIXEIRA, VERONICA RODRIGUES; COSTA, FABRICIO FALCONI; MELO, CAMILA MORAIS; DOS SANTOS, SOFIA NASCIMENTO; NONOGAKI, SUELY; LIU, FU-TONG; BERNARDES, EMERSON SOARES; CAMARGO, ANAMARIA ARANHA; CHAMMAS, ROGER. Galectin-3 disruption impaired tumoral angiogenesis by reducing VEGF secretion from TGF beta 1-induced macrophages. CANCER MEDICINE, v. 3, n. 2, p. 201-214, APR 2014. Web of Science Citations: 21.
CURY, NATHALIA M.; FERRAZ, VICTOR E. F.; SILVA, JR., WILSON A. TP53 p.R337H prevalence in a series of Brazilian hereditary breast cancer families. Hereditary Cancer in Clinical Practice, v. 12, MAR 13 2014. Web of Science Citations: 8.
ALVES, CLEIDSON PADUA; FONSECA, ALINE SIMONETI; MUYS, BRUNA RODRIGUES; BUENO, RAFAELA DE BARROS E LIMA; BUERGER, MATHEUS CARVALHO; DE SOUZA, JORGE E. S.; VALENTE, VALERIA; ZAGO, MARCO ANTONIO; SILVA, JR., WILSON ARAUJO. Brief Report: The lincRNA Hotair Is Required for Epithelial-to-Mesenchymal Transition and Stemness Maintenance of Cancer Cell Lines. Stem Cells, v. 31, n. 12, p. 2827-2832, DEC 2013. Web of Science Citations: 115.
WINKLER, THOMAS; HONG, SO GUN; DECKER, JAKE E.; MORGAN, MARY J.; WU, CHUANFENG; HUGHES, WILLIAM M.; YANG, YANQIN; WANGSA, DANNY; PADILLA-NASH, HESED M.; RIED, THOMAS; YOUNG, NEAL S.; DUNBAR, CYNTHIA E.; CALADO, RODRIGO T. Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs. Journal of Clinical Investigation, v. 123, n. 5, p. 1952-1963, MAY 2013. Web of Science Citations: 43.
REGO, EDUARDO M.; KIM, HAESOOK T.; RUIZ-ARGUEELLES, GUILLERMO J.; UNDURRAGA, MARIA SOLEDAD; URIARTE, MARIA DEL ROSARIO; JACOMO, RAFAEL H.; GUTIERREZ-AGUIRRE, HOMERO; MELO, RAUL A. M.; BITTENCOURT, ROSANE; PASQUINI, RICARDO; PAGNANO, KATIA; FAGUNDES, EVANDRO M.; CHAUFFAILLE, MARIA DE LOURDES; CHIATTONE, CARLOS S.; MARTINEZ, LEM; MEILLON, LUIS A.; GOMEZ-ALMAGUER, DAVID; KWAAN, HAU C.; GARCES-EISELE, JAVIER; GALLAGHER, ROBERT; NIEMEYER, CHARLOTTE M.; SCHRIER, STANLEY L.; TALLMAN, MARTIN; GRIMWADE, DAVID; GANSER, ARNOLD; BERLINER, NANCY; RIBEIRO, RAUL C.; LO-COCO, FRANCESCO; LOEWENBERG, BOB; SANZ, MIGUEL A. Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL. Blood, v. 121, n. 11, p. 1935-1943, MAR 14 2013. Web of Science Citations: 35.
TAMAROZZI, M. B.; SOARES, S. G.; SA-NUNES, A.; PAIVA, H. H.; SAGGIORO, F. P.; GARCIA, A. B.; LUCENA-ARAUJO, A. R.; FALCAO, R. P.; BORDIN, J. O.; REGO, E. M. Comparative analysis of the pathological events involved in immune and non-immune TRALI models. Vox Sanguinis, v. 103, n. 4, p. 309-321, NOV 2012. Web of Science Citations: 4.
RAMAO, ANELISA; GIMENEZ, MARCELA; LAURE, HELEN JULIE; IZUMI, CLARICE; DOS SANTOS VIDA, RODRIGO CESAR; OBA-SHINJO, SUELI; NAGAHASHI MARIE, SUELY KAZUE; ROSA, JOSE CESAR. Changes in the expression of proteins associated with aerobic glycolysis and cell migration are involved in tumorigenic ability of two glioma cell lines. PROTEOME SCIENCE, v. 10, SEP 3 2012. Web of Science Citations: 18.
CETRULO LORENZI, JULIO CESAR; BRUM, DORALINA G.; ZANETTE, DALILA L.; ALVES SOUZA, ALESSANDRA DE PAULA; BARBUZANO, FERNANDA GONCALVES; DOS SANTOS, ANTONIO CARLOS; BARREIRA, AMILTON ANTUNES; SILVA, JR., WILSON ARAUJO. miR-15a and 16-1 Are Downregulated in CD4(+) T Cells of Multiple Sclerosis Relapsing Patients. International Journal of Neuroscience, v. 122, n. 8, p. 466-471, AUG 2012. Web of Science Citations: 32.
JACOMO, RAFAEL H.; SANTANA-LEMOS, BARBARA A.; LIMA, ANA SILVIA G.; ASSIS, PATRICIA A.; LANGE, ANA PAULA A.; FIGUEIREDO-PONTES, LORENA L.; OLIVEIRA, LUCIANA O.; BASSI, SARAH C.; BENICIO, MARIANA T. L.; BAGGIO, MARCIA S.; GARCIA, AGLAIR B.; FALCAO, ROBERTO P.; REGO, EDUARDO M. Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia. Blood, v. 120, n. 1, p. 207-213, JUL 5 2012. Web of Science Citations: 11.
DOS SANTOS, G. A. S.; ABREU E LIMA, R. S.; PESTANA, C. R.; LIMA, A. S. G.; SCHEUCHER, P. S.; THOME, C. H.; GIMENES-TEIXEIRA, H. L.; SANTANA-LEMOS, B. A. A.; LUCENA-ARAUJO, A. R.; RODRIGUES, F. P.; NASR, R.; UYEMURA, S. A.; FALCAO, R. P.; DE THE, H.; PANDOLFI, P. P.; CURTI, C.; REGO, E. M. (+)alpha-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo. LEUKEMIA, v. 26, n. 3, p. 451-460, MAR 2012. Web of Science Citations: 36.
FONTES, A. M.; MELO, F. U. F.; GREENE, L. J.; FACA, V. M.; LIN, Y.; GERSON, S. L.; COVAS, D. T. Production of human factor VIII-FL in 293T cells using the bicistronic MGMT(P140K)-retroviral vector. Genetics and Molecular Research, v. 11, n. 1, p. 775-789, 2012. Web of Science Citations: 2.
ONUCHIC, ANA CLAUDIA; MACHADO, CAMILA M. L.; SAITO, RENATA F.; RIOS, FRANCISCO J.; JANCAR, SONIA; CHAMMAS, ROGER. Expression of PAFR as Part of a Prosurvival Response to Chemotherapy: A Novel Target for Combination Therapy in Melanoma. Mediators of Inflammation, 2012. Web of Science Citations: 26.
MELO, FABIANA H. M.; BUTERA, DIEGO; JUNQUEIRA, MARA DE SOUZA; HSU, DANIEL K.; MOURA DA SILVA, ANA MARIA; LIU, FU-TONG; SANTOS, MARINILICE F.; CHAMMAS, ROGER. The Promigratory Activity of the Matricellular Protein Galectin-3 Depends on the Activation of PI-3 Kinase. PLoS One, v. 6, n. 12 DEC 28 2011. Web of Science Citations: 9.
DALMAZZO, LEANDRO F. F.; SANTANA-LEMOS, BARBARA A.; JACOMO, RAFAEL H.; GARCIA, AGLAIR B.; REGO, EDUARDO M.; DA FONSECA, LUIZ M.; FALCAO, ROBERTO P. Antibody-targeted horseradish peroxidase associated with indole-3-acetic acid induces apoptosis in vitro in hematological malignancies. Leukemia Research, v. 35, n. 5, p. 657-662, MAY 2011. Web of Science Citations: 12.
DE FIGUEIREDO-PONTES, LORENA L.; ASSIS, PATRICIA A.; SANTANA-LEMOS, BARBARA A. A.; JACOMO, RAFAEL H.; LIMA, ANA SILVIA G.; GARCIA, AGLAIR B.; THOME, CAROLINA H.; ARAUJO, AMELIA G.; PANEPUCCI, RODRIGO A.; ZAGO, MARCO A.; NAGLER, ARNON; FALCAO, ROBERTO P.; REGO, EDUARDO M. Halofuginone Has Anti-Proliferative Effects in Acute Promyelocytic Leukemia by Modulating the Transforming Growth Factor Beta Signaling Pathway. PLoS One, v. 6, n. 10, p. e26713, 2011. Web of Science Citations: 20.
DE MOLFETTA, GREICE ANDREOTTI; ZANETTE, DALILA LUCIOLA; PANEPUCCI, RODRIGO ALEXANDRE; DINARTE DOS SANTOS, ANEMARIE RAMOS; DA SILVA, JR., WILSON ARAUJO; ZAGO, MARCO ANTONIO. Role of NFKB2 on the early myeloid differentiation of CD34+ hematopoietic stem/progenitor cells. DIFFERENTIATION, v. 80, n. 4-5, p. 195-203, NOV-DEC 2010. Web of Science Citations: 12.
OTAKE, ANDREIA HANADA; MATTAR, ANA LUCIA; FREITAS, HELANO CARIOCA; LONGO MACHADO, CAMILA MARIA; NONOGAKI, SUELY; FUJIHARA, CLARICE KAZUE; ZATZ, ROBERTO; CHAMMAS, ROGER. Inhibition of angiotensin II receptor 1 limits tumor-associated angiogenesis and attenuates growth of murine melanoma. Cancer Chemotherapy and Pharmacology, v. 66, n. 1, p. 79-87, MAY 2010. Web of Science Citations: 37.
FREITAS, ROSANA APARECIDA; SILVA DOS SANTOS, GUILHERME AUGUSTO; GIMENES TEIXEIRA, HAMILTON LUIZ; SCHEUCHER, PRISCILA SANTOS; LUCENA-ARAUJO, ANTONIO ROBERTO; GOUVEIA LIMA, ANA SILVIA; ABREU E LIMA, RODRIGO SIQUEIRA; GARCIA, AGLAIR BERGAMO; JORDAO, JR., ALCEU AFONSO; FAICAO, ROBERTO PASSETTO; VANNUCCHI, HELIO; REGO, EDUARDO MAGALHAES. Apoptosis induction by (+)alpha-tocopheryl succinate in the absence or presence of all-trans retinoic acid and arsenic trioxide in NB4, NB4-R2 and primary APL cells. Leukemia Research, v. 33, n. 7, p. 958-963, JUL 2009. Web of Science Citations: 6.
R.C.V. CARRARA; M.D. ORELLANA; A.M. FONTES; P.V.B. PALMA; S. KASHIMA; M.R. MENDES; M.A. COUTINHO; J.C. VOLTARELLI; D.T. COVAS. Mesenchymal stem cells from patients with chronic myeloid leukemia do not express BCR-ABL and have absence of chimerism after allogeneic bone marrow transplant. Brazilian Journal of Medical and Biological Research, v. 40, n. 1, p. 57-67, Jan. 2007.
APARECIDA M. FONTES; MARISTELA D. ORELLANA; PATRICIA V.B. PALMA; DIMAS T. COVAS. Maturation of dendritic cells following exposure to different maturational stimuli. Revista Brasileira de Hematologia e Hemoterapia, v. 28, n. 2, p. 89-96, Jun. 2006.
REGO, E. M.; RUGGERO, D.; TRIBIOLI, C.; CATTORETTI, G.; KOGAN, S.; REDNER, R. L.; PANDOLFI, P. P. Leukemia with distinct phenotypes in transgenic mice expressing PML/ RAR alpha, PLZF/RAR alpha or NPM/RAR alpha. Oncogene, v. 25, n. 13, p. 1974-1979, Mar. 2006.
PROTO-SIQUEIRA‚ R.; FIGUEIREDO-PONTES‚ L.L.; PANEPUCCI‚ R.A.; GARCIA‚ A.B.; RIZZATTI‚ E.G.; NASCIMENTO‚ F.M.; ISHIKAWA‚ H.C.F.; LARSON‚ R.E.; FALCÃO‚ R.P.; SIMPSON‚ A.J.; OTHERS. PRAME is a membrane and cytoplasmic protein aberrantly expressed in chronic lymphocytic leukemia and mantle cell lymphoma. Leukemia Research, v. 30, n. 11, p. 1333-1339, 2006.
NUNES‚ F.M.F.; VALENTE‚ V.; SOUSA‚ J.F.; CUNHA‚ M.A.V.; PINHEIRO‚ D.G.; MAIA‚ R.M.; ARAUJO‚ D.D.; COSTA‚ M.C.R.; MARTINS‚ W.K.; CARVALHO‚ A.F.; OTHERS. The use of Open Reading frame ESTs (ORESTES) for analysis of the honey bee transcriptome. BMC Genomics, v. 5, n. 1, p. 84, 2004.
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Filed patent(s) as a result of this research project

MOLÉCULA HÍBRIDA PARA DIAGNÓSTICO E /OU PROGNÓSTICO DE DOENÇAS CRÔNICO-DEGENERATIVAS, INFECCIOSAS E DO DESENVOLVIMENTO PI0501095-0 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Universidade de São Paulo (USP) . Roger Chammas; Fabiana Henriques Machado de Melo; Diego Alberto Butera Wadsworth; Ana Maria Moura da Silva - February 2005, 24