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Gastrointestinal motility: clinical investigations, physiopathology and biopharmaceutical

Grant number: 10/07639-9
Support type:Research Projects - Thematic Grants
Duration: March 01, 2011 - February 28, 2015
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Ricardo Brandt de Oliveira
Grantee:Ricardo Brandt de Oliveira
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Pesquisadores principais:
José Ricardo de Arruda Miranda ; Luiz Ernesto de Almeida Troncon ; Oswaldo Baffa Filho ; Roberto Oliveira Dantas
Assoc. researchers:Antonio Adilton Oliveira Carneiro ; Armenio Aguiar dos Santos ; Carlos Antonio Caramori ; Cristina Helena dos Reis Serra ; Eder Rezende Moraes ; Marcellus Henrique Loiola Ponte de Souza ; Miguel Ângelo Nobre e Souza ; Pedro Jorge Caldas Magalhães ; Raul Cesar Evangelista ; Wellington Monteiro Machado
Associated grant(s):14/16489-1 - 2014 IEEE International Ultrasonics Symposium, AR.EXT
14/11914-6 - 19th International Conference on Biomagnetism - BIOMAG 2014, AR.EXT
13/15915-4 - XXII International Materials Research Congress, AR.EXT
Associated scholarship(s):13/09095-4 - Electrical and mechanical study of colonic motility under influence of ulcerative colitis, BP.DR
13/03639-2 - Biosusceptometry Alternating Current tomography (TBAC): New Instrumentations and characterizations., BP.MS
12/18420-3 - Implementation of magneto motive technique in an ultrasound diagnostic equipment, BP.MS
+ associated scholarships 13/05044-6 - Evaluation of gastric motility in diabetic pregnant rats, BP.IC
12/20348-9 - STUDY OF GASTRIC MOTILITY IN PREGNANT RATS DIABETIC, BP.MS
12/11798-0 - Gellan gum microcapsules coated with resistant starch/pectin as a strategy for oral administration of insulin., BP.DR
12/13726-7 - Assessment of dissolution time of coating and disintegration in magnetic tablet by Biosuceptometria AC, BP.IC
12/01467-7 - Analysis of genetic aspects in Functional Gastrointestinal Disorders - Functional Constipation, BP.PD
11/18696-6 - New ACB applications using magnetic nanoparticles, BP.DR
11/10144-4 - Analysis of gastroretentive floating systems by AC Biosusceptometry, BP.PD
11/13402-4 - Software development for generating of Magneto-acoustography image in a ultrasound equipment of diagnostic by image., BP.IC
11/05011-5 - Study of gastric and esophagus dynamics on cintilographic images by demons technique, BP.MS - associated scholarships

Abstract

Until recently, gastrointestinal motility has been studied using invasive methods. On the other hand, work from members of our team has led to the development of harmless, non-invasive biomagnetic techniques and new materials, which have been successfully, applied in gastrointestinal motility studies. Hence, conventional and novel methods could be employed to improve the knowledge on the regulation of gastrointestinal function and, consequently, its dysfunctions. This research project aims at refining current non-invasive methods for the study of gastric motility, to improve biomagnetic techniques developed locally and, particularly, to apply these methodological innovations in the investigation of specific aspects of gastrointestinal physiology and pathophysiology as well as its relationships with drug delivery following the administration of solid dosage forms. This project will be developed into four stages: clinical, experimental models, biopharmaceutical, sensors and materials. A number of specific subprojects involving a range of methodological approaches in different studies in healthy volunteers and patients as well as animal and in vitro studies will be carried out to fulfill the more general objective of expanding the knowledge on the field. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ICHIKAWA, RODRIGO U.; PARRA, JOAO P. R. L. L.; MARTINS, MURILLO L.; YOSHITO, WALTER K.; SAEKI, MARGARIDA J.; TURRILLAS, XAVIER; MARTINEZ, LUIS G. Size-Strain Analysis of Iron-Excess Mn-Zn Ferrite Nanoparticles Using Synchrotron Diffraction and Its Correlation with Magnetic Saturation and Isoelectric pH. Journal of Nanoscience and Nanotechnology, v. 18, n. 8, p. 5697-5703, AUG 2018. Web of Science Citations: 1.
QUINI, CAIO C.; PROSPERO, ANDRE G.; CALABRESI, MARCOS F. F.; MORETTO, GUSTAVO M.; ZUFELATO, NICHOLAS; KRISHNAN, SUNIL; PINA, DIANA R.; OLIVEIRA, RICARDO B.; BAFFA, OSWALDO; BAKUZIS, ANDRIS F.; MIRANDA, JOSE R. A. Real-time liver uptake and biodistribution of magnetic nanoparticles determined by AC biosusceptometry. Nanomedicine-Nanotechnology Biology and Medicine, v. 13, n. 4, p. 1519-1529, MAY 2017. Web of Science Citations: 9.
DE SOUZA, MICHELE N.; XAVIER, FERNANDO E. B.; SECAF, MARIE; TRONCON, LUIZ E. A.; DE OLIVEIRA, RICARDO B.; MORAES, EDER R. Evaluation of oesophageal transit velocity using the improved Demons technique. NUCLEAR MEDICINE COMMUNICATIONS, v. 37, n. 1, p. 87-91, JAN 2016. Web of Science Citations: 0.
DIEGO RONALDO THOMAZ SAMPAIO; FELIPE WILKER GRILLO; ALEXANDRE COLELLO BRUNO; THEO ZEFERINO PAVAN; ANTONIO ADILTON OLIVEIRA CARNEIRO. A magneto-motive ultrasound platform designed for pre-clinical and clinical applications. Res. Biomed. Eng., v. 32, n. 4, p. 337-346, Dez. 2016.
QUINI, CAIO C.; MATOS, JULIANA F.; PROSPERO, ANDRE G.; CALABRESI, MARCOS FELIPE F.; ZUFELATO, NICHOLAS; BAKUZIS, ANDRIS F.; BAFFA, OSWALDO; MIRANDA, JOSE RICARDO A. Renal perfusion evaluation by alternating current biosusceptometry of magnetic nanoparticles. Journal of Magnetism and Magnetic Materials, v. 380, p. 2-6, APR 15 2015. Web of Science Citations: 6.
MARTINS, MURILLO L.; CALABRESI, MARCOS F.; QUINI, CAIO; MATOS, JULIANA F.; MIRANDA, JOSE R. A.; SAEKI, MARGARIDA J.; BORDALLO, HELOISA N. Enhancing the versatility of alternate current biosusceptometry (ACB) through the synthesis of a dextrose-modified tracer and a magnetic muco-adhesive cellulose gel. Materials Science & Engineering C-Materials for Biological Applications, v. 48, p. 80-85, MAR 1 2015. Web of Science Citations: 4.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
Filed patent(s) as a result of this research project

Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação US61/722,531 - Universidade Estadual Paulista (UNESP) . Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - November 2012, 05