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Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas

Abstract

Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent neoplasias and its main risk factors are alcohol and tobacco exposure. Despite intense research and recent advances in detection and therapeutic strategies, the five-year survival rate remains low in this group of tumors. Recent publications suggest that HPV infection is related to head and neck tumor genesis and may alter the tumor profile and outcome. Clinical, histopathological and molecular factors have been associated with prognosis of HN cancer, including the presence of lymph node metastasis, abnormal gene methylation and abnormal expression of genes and proteins involved in critical cellular of processes. The present study aims to investigate lifestyle factors, HPV infection, as well as gene and protein expression patterns and clinical, histopathological and molecular factors associated with development and prognosis of HNSCC. After integration of the data, the study also aims to develop a predictive model to identify patients at risk for morbid events, including regional and distant metastasis, low global and disease-free survival and second primary tumors. This project represents the first initiative to obtain financial support to organize a Brazilian research network to study head and neck cancer, which will be integrated into the international network InterCHANGE. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Las nuevas caras del cáncer 
The new faces of cancer 
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (24)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GIRALDI, L.; LEONCINI, E.; PASTORINO, R.; WUNSCH-FILHO, V.; DE CARVALHO, M.; LOPEZ, R.; CADONI, G.; ARZANI, D.; PETRELLI, L.; MATSUO, K.; et al. Alcohol and cigarette consumption predict mortality in patients with head and neck cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Annals of Oncology, v. 28, n. 11, p. 2843-2851, . (10/51168-0, 04/12054-9)
ANANTHARAMAN, DEVASENA; ABEDI-ARDEKANI, BEHNOUSH; BEACHLER, DANIEL C.; GHEIT, TARIK; OLSHAN, ANDREW F.; WISNIEWSKI, KATHY; WUNSCH-FILHO, VICTOR; TOPORCOV, TATIANA N.; TAJARA, ELOIZA H.; LEVI, JOSE EDUARDO; et al. Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer. International Journal of Cancer, v. 140, n. 9, p. 1968-1975, . (10/51168-0, 04/12054-9)
ARANTES, L. M. R. B.; DE CARVALHO, A. C.; MELENDEZ, M. E.; CENTRONE, C. C.; GOIS-FILHO, J. F.; TOPORCOV, T. N.; CALY, D. N.; TAJARA, E. H.; GOLONI-BERTOLLO, E. M.; CARVALHO, A. L.; et al. Validation of methylation markers for diagnosis of oral cavity cancer. EUROPEAN JOURNAL OF CANCER, v. 51, n. 5, p. 632-641, . (10/51168-0, 11/02864-7)
STEFANINI, ANA CAROLINA B.; DA CUNHA, BIANCA RODRIGUES; HENRIQUE, TIAGO; TAJARA, ELOIZA H.. Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes. DISEASE MARKERS, . (10/51168-0)
SEVERINO, PATRICIA; OLIVEIRA, LILIANE SANTANA; ANDREGHETTO, FLAVIA MAZIERO; TORRES, NATALIA; CURIONI, OTAVIO; CURY, PATRICIA MALUF; TOPORCOV, TATIANA NATASHA; PASCHOAL, ALEXANDRE ROSSI; DURHAM, ALAN MITCHELL. Small RNAs in metastatic and non-metastatic oral squamous cell carcinoma. BMC MEDICAL GENOMICS, v. 8, . (10/51168-0)
HENRIQUE, TIAGO; FREITAS DA SILVEIRA, NELSON JOSE; CUNHA VOLPATO, ARTHUR HENRIQUE; MIOTO, MAYRA MATARUCO; BUZZO STEFANINI, ANA CAROLINA; FARES, ADIL BACHIR; DA SILVA CASTRO ANDRADE, JOAO GUSTAVO; MASSON, CAROLINA; MENDOZA LOPEZ, ROSSANA VERONICA; NUNES, FABIO DAUMAS; et al. u HNdb: an integrated database of gene and protein information on head and neck squamous cell carcinoma. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, . (10/51168-0)
SEVERINO, PATRICIA; OLIVEIRA, LILIANE SANTANA; TORRES, NATALIA; ANDREGHETTO, FLAVIA MAZIERO; GUARIZO KLINGBEIL, MARIA DE FATIMA; MOYSES, RAQUEL; WUENSCH-FILHO, VICTOR; NUNES, FABIO DAUMAS; MATHOR, MONICA BEATRIZ; PASCHOAL, ALEXANDRE ROSSI; et al. High-throughput sequencing of small RNA transcriptomes reveals critical biological features targeted by microRNAs in cell models used for squamous cell cancer research. BMC Genomics, v. 14, . (10/51168-0, 09/04166-5)
DE OLIVEIRA FIGUEIREDO, REJANE AUGUSTA; WEIDERPASS, ELISABETE; TAJARA, ELOIZA HELENA; STROM, PETER; CARVALHO, ANDRE LOPES; DE CARVALHO, MARCOS BRASILINO; KANDA, JOSSI LEDO; MOYSES, RAQUEL AJUB; WUNSCH-FILHO, VICTOR. Diabetes mellitus, metformin and head and neck cancer. Oral Oncology, v. 61, p. 47-54, . (10/51168-0, 13/20548-0, 13/21702-3, 14/18893-4)
KHETAN, PRERNA; BOFFETTA, PAOLO; LUCE, DANIELE; STUCKER, ISABELLE; CURADO, MARIA PAULA; MENEZES, ANA; WUNSCH-FILHO, VICTOR; AHRENS, WOLFGANG; LAGIOU, PAGONA; SERRAINO, DIEGO; et al. Occupations and the Risk of Head and Neck Cancer A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, v. 61, n. 5, p. 397-404, . (10/51168-0, 04/12054-9)
DI CREDICO, GIOIA; EDEFONTI, VALERIA; POLESEL, JERRY; PAULI, FRANCESCO; TORELLI, NICOLA; SERRAINO, DIEGO; NEGRI, EVA; LUCE, DANIELE; STUCKER, ISABELLE; MATSUO, KEITARO; et al. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach. Oral Oncology, v. 94, p. 47-57, . (10/51168-0, 04/12054-9)
DA CUNHA, BIANCA RODRIGUES; DOMINGOS, CELIA; BUZZO STEFANINI, ANA CAROLINA; HENRIQUE, TIAGO; POLACHINI, GIOVANA MUSSI; CASTELO-BRANCO, PEDRO; TAJARA, ELOIZA HELENA. Cellular Interactions in the Tumor Microenvironment: The Role of Secretome. JOURNAL OF CANCER, v. 10, n. 19, p. 4574-4587, . (13/03839-1, 12/06048-2, 10/51168-0)
LEONCINI, EMANUELE; VUKOVIC, VLADIMIR; CADONI, GABRIELLA; GIRALDI, LUCA; PASTORINO, ROBERTA; ARZANI, DARIO; PETRELLI, LIVIA; WUNSCH-FILHO, VICTOR; TOPORCOV, TATIANA NATASHA; MOYSES, RAQUEL AYUB; et al. Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium. EUROPEAN JOURNAL OF EPIDEMIOLOGY, v. 33, n. 12, p. 1205-1218, . (10/51168-0, 04/12054-9)
GORMLEY, MARK; YARMOLINSKY, JAMES; DUDDING, TOM; BURROWS, KIMBERLEY; MARTIN, RICHARD M.; THOMAS, STEVEN; TYRRELL, JESSICA; BRENNAN, PAUL; PRING, MIRANDA; BOCCIA, STEFANIA; et al. Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study. PLOS GENETICS, v. 17, n. 4, . (10/51168-0)
KACHURI, LINDA; SAARELA, OLLI; BOJESEN, STIG EGIL; SMITH, GEORGE DAVEY; LIU, GEOFFREY; LANDI, MARIA TERESA; CAPORASO, NEIL E.; CHRISTIANI, DAVID C.; JOHANSSON, MATTIAS; PANICO, SALVATORE; et al. Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers. International Journal of Epidemiology, v. 48, n. 3, p. 751-766, . (10/51168-0, 04/12054-9)
LESSEUR, CORINA; DIERGAARDE, BRENDA; OLSHAN, ANDREW F.; WUNSCH-FILHO, VICTOR; NESS, ANDREW R.; LIU, GEOFFREY; LACKO, MARTIN; ELUF-NETO, JOSE; FRANCESCHI, SILVIA; LAGIOU, PAGONA; et al. Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer. Nature Genetics, v. 48, n. 12, p. 1544-1550, . (10/51168-0, 04/12054-9)
CHANG, CHUN-PIN; CHANG, SHEN-CHIH; CHUANG, SHU-CHUN; BERTHILLER, JULIEN; FERRO, GILLES; MATSUO, KEITARO; WUNSCH-FILHO, VICTOR; TOPORCOV, TATIANA N.; DE CARVALHO, MARCOS BRASILINO; LA VECCHIA, CARLO; et al. Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE). CANCER EPIDEMIOLOGY, v. 63, . (10/51168-0)
SHETE, SANJAY; LIU, HONGLIANG; WANG, JIAN; YU, ROBERT; STURGIS, ERICH M.; LI, GUOJUN; DAHLSTROM, KRISTINA R.; LIU, ZHENSHENG; AMOS, CHRISTOPHER I.; WEI, QINGYI. A Genome-Wide Association Study Identifies Two Novel Susceptible Regions for Squamous Cell Carcinoma of the Head and Neck. Cancer Research, v. 80, n. 12, p. 2451-2460, . (04/12054-9, 10/51168-0)
ARCHANJO, ANDERSON BARROS; EVANGELISTA MONTEIRO DE ASSIS, ARICIA LEONE; DE OLIVEIRA, MAYARA MOTA; MENDES, SUZANNY OLIVEIRA; BORCOI, ALINE RIBEIRO; MAIA, LUCAS DE LIMA; DE SOUZA, RAFAEL PEREIRA; DE CICCO, RAFAEL; SAITO, KELLY CRISTINA; KIMURA, EDNA TERUKO; et al. Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival. SCIENTIFIC REPORTS, v. 10, n. 1, . (04/12054-9, 10/51168-0)
BRAVI, FRANCESCA; LEE, YUAN-CHIN AMY; HASHIBE, MIA; BOFFETTA, PAOLO; CONWAY, DAVID I.; FERRARONI, MONICA; LA VECCHIA, CARLO; EDEFONTI, VALERIA; INVESTIGATORS, INHANCE CONSORTIUM. Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer. ORAL DISEASES, v. 27, n. 1, . (10/51168-0, 04/12054-9)
PERDOMO, SANDRA; ANANTHARAMAN, DEVASENA; FOLL, MATTHIEU; ABEDI-ARDEKANI, BEHNOUSH; DURAND, GEOFFROY; ROSA, LUCIANA ALBINA REIS; HOLMILA, REETTA; LE CALVEZ-KELM, FLORENCE; TAJARA, ELOIZA H.; WUNSCH-FILHO, VICTOR; et al. Genomic analysis of head and neck cancer cases from two high incidence regions. PLoS One, v. 13, n. 1, . (10/51168-0, 04/12054-9)
SILVA, ELISANGELA DE PAULA; MARTI, LUCIANA CAVALHEIRO; ANDREGHETTO, FLAVIA MAZIERO; DE SALES, ROMARIO OLIVEIRA; HOBERMAN, MARTIN; DIAS, BARBARA DOS SANTOS; ALVES DINIZ, LARISSA FIGUEIREDO; DOS SANTOS, ALESSANDRO MARINS; MOYSES, RAQUEL AJUB; CURIONI, OTAVIO ALBERTO; et al. Extracellular vesicles cargo from head and neck cancer cell lines disrupt dendritic cells function and match plasma microRNAs. SCIENTIFIC REPORTS, v. 11, n. 1, . (10/51168-0)
TOPORCOV, TATIANA NATASHA; ZNAOR, ARIANA; ZHANG, ZUO-FENG; YU, GUO-PEI; WINN, DEBORAH M.; WEI, QINGYI; VILENSKY, MARTA; VAUGHAN, THOMAS; THOMSON, PETER; TALAMINI, RENATO; et al. Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium. International Journal of Epidemiology, v. 44, n. 1, p. 169-185, . (10/51168-0, 04/12054-9)
BERTHILLER, JULIEN; STRAIF, KURT; AGUDO, ANTONIO; AHRENS, WOLFGANG; DOS SANTOS, ALEXANDRE BEZERRA; BOCCIA, STEFANIA; CADONI, GABRIELLA; CANOVA, CRISTINA; CASTELLSAGUE, XAVIER; CHEN, CHU; et al. Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis. International Journal of Epidemiology, v. 45, n. 3, p. 835-845, . (10/51168-0)
LESSEUR, CORINA; FERREIRO-IGLESIAS, AIDA; MCKAY, JAMES D.; BOSSE, YOHAN; JOHANSSON, MATTIAS; GABORIEAU, VALERIE; LANDI, MARIA TERESA; CHRISTIANI, DAVID C.; CAPORASO, NEIL C.; BOJESEN, STIG E.; et al. Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers. PLOS GENETICS, v. 17, n. 3, . (10/51168-0, 04/12054-9)

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