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Head and neck and esophageal squamous cell carcinoma: biomarkers derived from genomics and proteomics

Grant number: 02/01520-3
Support type:Genome Research Grants
Duration: November 01, 2002 - February 28, 2005
Field of knowledge:Biological Sciences - Genetics
Principal Investigator:Eloiza Helena Tajara da Silva
Grantee:Eloiza Helena Tajara da Silva
Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil

Abstract

The primary aim of the present project is to search for new tumor markers that may be relevant both for diagnosis, prognosis and classification of head and neck (HN) and esophageal (E) squamous cell carcinomas, and for more effective therapeutic measures. Specific aims include: (1) By using genomic and proteomic approaches, investigate differences in gene and protein expression profiles between HN/E carcinomas and their apparently normal counterparts. (2) Evaluate the structure of proteins which have potential of playing a functional role in the induction and/or sustenance of malignant phenotypes in humans. By molecular modeling, obtain three-dimensional structures of possible protein targets identified in the project. (3) By quantitative real time RT-PCR analysis, investigate the expression of markers identified in the projects FAPESP 00/103095-2, FAPESP 00/12739-0 and Clinical Genomics. (4) Determine the frequency of variants of expressed genes which showed evidence of alternative splicing in Human Cancer Genome Project. (AU)

Articles published in Agência FAPESP about the research grant
Proteins help in evaluating mouth cancer prognosis 
Human Papilloma Virus tumors on the head and neck are less aggressive  

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALVES, V. A. F.; NONOGAKI, S.; CURY, P. M.; WUENSCH-FILHO, V.; DE CARVALHO, M. B.; MICHALUART-JUNIOR, P.; MOYSES, R. A.; CURIONI, O. A.; FIGUEIREDO, D. L. A.; SCAPULATEMPO-NETO, C.; PARRA, E. R.; POLACHINI, G. M.; SILISTINO-SOUZA, R.; OLIANI, S. M.; SILVA-JUNIOR, W. A.; NOBREGA, F. G.; TAJARA, E. H.; ZAGO, M. A.; GENCAPO, HEAD \& NECK GENOME PROJECT. Annexin A1 subcellular expression in laryngeal squamous cell carcinoma. Histopathology, v. 53, n. 6, p. 715-727, DEC 2008. Web of Science Citations: 20.

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