| Grant number: | 02/01520-3 |
| Support type: | Genome Research Grants |
| Duration: | November 01, 2002 - February 28, 2005 |
| Field of knowledge: | Biological Sciences - Genetics - Human and Medical Genetics |
| Principal Investigator: | Eloiza Helena Tajara da Silva |
| Grantee: | Eloiza Helena Tajara da Silva |
| Home Institution: | Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil |
Abstract
The primary aim of the present project is to search for new tumor markers that may be relevant both for diagnosis, prognosis and classification of head and neck (HN) and esophageal (E) squamous cell carcinomas, and for more effective therapeutic measures. Specific aims include: (1) By using genomic and proteomic approaches, investigate differences in gene and protein expression profiles between HN/E carcinomas and their apparently normal counterparts. (2) Evaluate the structure of proteins which have potential of playing a functional role in the induction and/or sustenance of malignant phenotypes in humans. By molecular modeling, obtain three-dimensional structures of possible protein targets identified in the project. (3) By quantitative real time RT-PCR analysis, investigate the expression of markers identified in the projects FAPESP 00/103095-2, FAPESP 00/12739-0 and Clinical Genomics. (4) Determine the frequency of variants of expressed genes which showed evidence of alternative splicing in Human Cancer Genome Project. (AU)
| Matéria(s) publicada(s) na Agência FAPESP sobre o auxílio: |
| Proteins help in evaluating mouth cancer prognosis |
| Human Papilloma Virus tumors on the head and neck are less aggressive |