Advanced search
Start date
Betweenand

Mitochondrial bioenergetics, ion transport, redox state and DNA metabolism

Grant number: 10/51906-1
Support type:Research Projects - Thematic Grants
Duration: April 01, 2011 - March 31, 2016
Field of knowledge:Biological Sciences - Biochemistry
Principal Investigator:Alicia Juliana Kowaltowski
Grantee:Alicia Juliana Kowaltowski
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:Nadja Cristhina de Souza Pinto
Associated grant(s):12/02339-2 - Double strand break repair in mitochondrial DNA: identification and characterization of pathway, AV.EXT
Associated scholarship(s):13/04871-6 - Effects of caloric restriction on mitochondrial morphology, dynamics, bioenergetics and redox state, BP.PD
13/03556-0 - Effect of high fat diet on hepatocytes: impacts on ROS generation, BP.IC
11/13506-4 - Aminoacid metabolism and aging in Saccharomyces cerevisiae, BP.DD

Abstract

Changes in mitochondrial energy metabolism, ion transport, mtDNA metabolism and redox balance are associated with a variety of physiological and pathological conditions including aging, obesity, heart attack and the toxicity of environmental contaminants. The central aim of this project is to analyze the role of alterations in mitochondrial ion transport, energy and DNA metabolism and/or redox state in these physio-pathological conditions. We believe that a better understanding of the molecular mechanisms underlying the mitochondrial involvement in these processes will allow the development of interventions capable of controlling these unwelcome mitochondrial and cellular effects in pathological processes of strong impact in human health. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Less fat, more hair, young skin 
Caloric restriction can be beneficial to the brain 
Intermittent fasting deregulates the cerebral mechanism for controlling hunger  

Scientific publications (22)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ERTUZUN, TUGCE; SEMERCI, ASLI; CAKIR, MEHMET EMIN; EKMEKCIOGLU, AYSEGUL; GOK, MEHMET OGUZ; SOLTYS, DANIELA T.; DE SOUZA-PINTO, NADJA C.; SEZERMAN, UGUR; MUFTUOGLU, MELTEM. Investigation of base excision repair gene variants in late-onset Alzheimer's disease. PLoS One, v. 14, n. 8 AUG 15 2019. Web of Science Citations: 0.
FERREIRA, JULIO C. B.; CAMPOS, JULIANE C.; QVIT, NIR; QI, XIN; BOZI, LUIZ H. M.; BECHARA, LUIZ R. G.; LIMA, VANESSA M.; QUELICONI, BRUNO B.; DISATNIK, MARIE-HELENE; DOURADO, PAULO M. M.; KOWALTOWSKI, ALICIA J.; MOCHLY-ROSEN, DARIA. A selective inhibitor of mitofusin 1-beta IIPKC association improves heart failure outcome in rats. NATURE COMMUNICATIONS, v. 10, JAN 18 2019. Web of Science Citations: 4.
ABRANTES, ALINE B. DE P.; DIAS, GUSTAVO C.; SOUZA-PINTO, NADJA C.; BAPTISTA, MAURICIO S. p53-Dependent and p53-Independent Responses of Cells Challenged by Photosensitization. Photochemistry and Photobiology, v. 95, n. 1, p. 355-363, JAN 2019. Web of Science Citations: 2.
ROUBICEK, DEBORAH A.; DE SOUZA-PINTO, NADJA C. Mitochondria and mitochondrial DNA as relevant targets for environmental contaminants. Toxicology, v. 391, p. 100-108, NOV 1 2017. Web of Science Citations: 22.
FORNI, MARIA FERNANDA; PELOGGIA, JULIA; BRAGA, TARCIO T.; ORTEGA CHINCHILLA, JESUS EDUARDO; SHINOHARA, JORGE; NAVAS, CARLOS ARTURO; SARAIVA CAMARA, NIELS OLSEN; KOWALTOWSKI, ALICIA J. Caloric Restriction Promotes Structural and Metabolic Changes in the Skin. CELL REPORTS, v. 20, n. 11, p. 2678-2692, SEP 12 2017. Web of Science Citations: 10.
SANTOS, CARLA SANTANA; KOWALTOWSKI, ALICIA J.; BERTOTTI, MAURO. Single Cell Oxygen Mapping (SCOM) by Scanning Electrochemical Microscopy Uncovers Heterogeneous Intracellular Oxygen Consumption. SCIENTIFIC REPORTS, v. 7, SEP 12 2017. Web of Science Citations: 7.
MORI, MATEUS P.; COSTA, RUTE A. P.; SOLTYS, DANIELA T.; FREIRE, THIAGO DE S.; ROSSATO, FRANCO A.; AMIGO, IGNACIO; KOWALTOWSKI, ALICIA J.; VERCESI, ANBAL E.; DE SOUZA-PINTO, NADJA C. Lack of XPC leads to a shift between respiratory complexes I and II but sensitizes cells to mitochondrial stress. SCIENTIFIC REPORTS, v. 7, MAR 13 2017. Web of Science Citations: 6.
AMIGO, IGNACIO; MENEZES-FILHO, SERGIO LUIZ; LUEVANO-MARTINEZ, LUIS ALBERTO; CHAUSSE, BRUNO; KOWALTOWSKI, ALICIA J. Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity. AGING CELL, v. 16, n. 1, p. 73-81, FEB 2017. Web of Science Citations: 20.
CAMPOS, JULIANE C.; QUELICONI, BRUNO B.; BOZI, LUIZ H. M.; BECHARA, LUIZ R. G.; DOURADO, PAULO M. M.; ANDRES, ALLEN M.; JANNIG, PAULO R.; GOMES, KATIA M. S.; ZAMBELLI, VANESSA O.; ROCHA-RESENDE, CIBELE; GUATIMOSIM, SILVIA; BRUM, PATRICIA C.; MOCHLY-ROSEN, DARIA; GOTTLIEB, ROBERTA A.; KOWALTOWSKI, ALICIA J.; FERREIRA, JULIO C. B. Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure. AUTOPHAGY, v. 13, n. 8, p. 1304-1317, 2017. Web of Science Citations: 18.
QUELICONI, BRUNO B.; KOWALTOWSKI, ALICIA J.; GOTTLIEB, ROBERTA A. Bicarbonate Increases Ischemia-Reperfusion Damage by Inhibiting Mitophagy. PLoS One, v. 11, n. 12 DEC 14 2016. Web of Science Citations: 7.
AMIGO, IGNACIO; DA CUNHA, FERNANDA M.; FORNI, MARIA FERNANDA; GARCIA-NETO, WILSON; KAKIMOTO, PAMELA A.; LUEVANO-MARTINEZ, LUIS A.; MACEDO, FELIPE; MENEZES-FILHO, SERGIO L.; PELOGGIA, JULIA; KOWALTOWSKI, ALICIA J. Mitochondrial form, function and signalling in aging. Biochemical Journal, v. 473, n. 20, p. 3421-3449, OCT 2016. Web of Science Citations: 11.
SARAVIA, L. P. H.; ANANDHAKUMAR, S.; PARUSSULO, A. L. A.; MATIAS, T. A.; CALDEIRA DA SILVA, C. C.; KOWALTOWSKI, A. J.; ARAKI, K.; BERTOTTI, M. Development of a tetraphenylporphyrin cobalt (II) Modified glassy carbon electrode to monitor oxygen consumption in biological samples. Journal of Electroanalytical Chemistry, v. 775, p. 72-76, AUG 15 2016. Web of Science Citations: 6.
KAKIMOTO, PAMELA A.; KOWALTOWSKI, ALICIA J. Effects of high fat diets on rodent liver bioenergetics and oxidative imbalance. REDOX BIOLOGY, v. 8, p. 216-225, AUG 2016. Web of Science Citations: 38.
MAGDALON, JULIANA; CHIMIN, PATRICIA; BELCHIOR, THIAGO; NEVES, RODRIGO X.; VIEIRA-LARA, MARCEL A.; ANDRADE, MAYNARA L.; FARIAS, TALITA S.; BOLSONI-LOPES, ANDRESSA; PASCHOAL, VIVIAN A.; YAMASHITA, ALEX S.; KOWALTOWSKI, ALICIA J.; FESTUCCIA, WILLIAM T. Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v. 1861, n. 5, p. 430-438, MAY 2016. Web of Science Citations: 14.
RUAS, JULIANA S.; SIQUEIRA-SANTOS, EDILENE S.; AMIGO, IGNACIO; RODRIGUES-SILVA, ERIKA; KOWALTOWSKI, ALICIA J.; CASTILHO, ROGER F. Underestimation of the Maximal Capacity of the Mitochondrial Electron Transport System in Oligomycin-Treated Cells. PLoS One, v. 11, n. 3 MAR 7 2016. Web of Science Citations: 9.
FORNI, MARIA FERNANDA; PELOGGIA, JULIA; TRUDEAU, KYLE; SHIRIHAI, ORIAN; KOWALTOWSKI, ALICIA J. Murine Mesenchymal Stem Cell Commitment to Differentiation Is Regulated by Mitochondrial Dynamics. Stem Cells, v. 34, n. 3, p. 743-755, MAR 2016. Web of Science Citations: 39.
FORNI, MARIA FERNANDA; CHAUSSE, BRUNO; PELOGGIA, JULIA; KOWALTOWSKI, ALICIA J. Bioenergetic profiling in the skin. EXPERIMENTAL DERMATOLOGY, v. 25, n. 2, p. 147-148, FEB 2016. Web of Science Citations: 4.
SILVA-PORTELA, RITA C. B.; CARVALHO, FABIOLA M.; PEREIRA, CAROLINA P. M.; DE SOUZA-PINTO, NADJA C.; MODESTI, MAURO; FUCHS, ROBERT P.; AGNEZ-LIMA, LUCYMARA F. ExoMeg1: a new exonuclease from metagenomic library. SCIENTIFIC REPORTS, v. 6, JAN 27 2016. Web of Science Citations: 4.
LUEVANO-MARTINEZ, LUIS ALBERTO; FORNI, MARIA FERNANDA; DOS SANTOS, VALQUIRIA TIAGO; SOUZA-PINTO, NADJA C.; KOWALTOWSKI, ALICIA J. Cardiolipin is a key determinant for mtDNA stability and segregation during mitochondrial stress. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, v. 1847, n. 6-7, p. 587-598, JUN-JUL 2015. Web of Science Citations: 17.
SOLTYS, DANIELA TATHIANA; MARTINS PEREIRA, CAROLINA PARGA; ISHIBE, GABRIELA NAOMI; DE SOUZA-PINTO, NADJA CRISTHINA. Effects of post mortem interval and gender in DNA base excision repair activities in rat brains. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, v. 776, n. SI, p. 48-53, JUN 2015. Web of Science Citations: 3.
GOMES, KATIA M. S.; BECHARA, LUIZ R. G.; LIMA, VANESSA M.; RIBEIRO, MARCIO A. C.; CAMPOS, JULIANE C.; DOURADO, PAULO M.; KOWALTOWSKI, ALICIA J.; MOCHLY-ROSEN, DARIA; FERREIRA, JULIO C. B. Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: Benefits of Alda-1. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 179, p. 129-138, JAN 20 2015. Web of Science Citations: 26.
MUFTUOGLU, MELTEM; MORI, MATEUS P.; DE SOUZA-PINTO, NADJA C. Formation and repair of oxidative damage in the mitochondrial DNA. MITOCHONDRION, v. 17, p. 164-181, JUL 2014. Web of Science Citations: 29.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.