| Grant number: | 10/51906-1 |
| Support Opportunities: | Research Projects - Thematic Grants |
| Start date: | April 01, 2011 |
| End date: | March 31, 2016 |
| Field of knowledge: | Biological Sciences - Biochemistry - Metabolism and Bioenergetics |
| Principal Investigator: | Alicia Juliana Kowaltowski |
| Grantee: | Alicia Juliana Kowaltowski |
| Host Institution: | Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Pesquisadores principais: | Nadja Cristhina de Souza Pinto |
| Associated research grant(s): | 12/02339-2 - Double strand break repair in mitochondrial DNA: identification and characterization of pathway, AV.EXT |
| Associated scholarship(s): | 13/04871-6 - Effects of caloric restriction on mitochondrial morphology, dynamics, bioenergetics and redox state,
BP.PD 13/03556-0 - Effect of high fat diet on hepatocytes: impacts on ROS generation, BP.IC 11/13506-4 - Aminoacid metabolism and aging in Saccharomyces cerevisiae, BP.DD |
Abstract
Changes in mitochondrial energy metabolism, ion transport, mtDNA metabolism and redox balance are associated with a variety of physiological and pathological conditions including aging, obesity, heart attack and the toxicity of environmental contaminants. The central aim of this project is to analyze the role of alterations in mitochondrial ion transport, energy and DNA metabolism and/or redox state in these physio-pathological conditions. We believe that a better understanding of the molecular mechanisms underlying the mitochondrial involvement in these processes will allow the development of interventions capable of controlling these unwelcome mitochondrial and cellular effects in pathological processes of strong impact in human health. (AU)
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