Evaluation of the possible involvement of superantigens and bacterial biofilms in the pathogenesis of chronic rhinossinusitis with nasal polyps

• Grant number: 10/17580-1
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2011
• End date: April 30, 2013
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Edwin Tamashiro
• Grantee: Edwin Tamashiro
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Fabiana Cardoso Pereira Valera ; Wilma Terezinha Anselmo Lima

Abstract

Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a common and prevalent disease that affects 4% of the general population. Among the etiopathogenic hypothesis of CRSwNP are the bacterial biofilms paradigm and the inflammatory modulation promoted by superantigens. As biofilms have the capacity to adhere to mucosal surfaces, they could maintain the inflammatory process either by direct lesion to the epithelium or through the production of exogens toxins, like the superatigens. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CANTAREIRA SABINO, HENRIQUE AUGUSTO; PEREIRA VALERA, FABIANA CARDOSO; ARAGON, DAVI CASALE; FANTUCCI, MARINA ZILIO; TITONELI, CAROLINA CARNEIRO; MARTINEZ, ROBERTO; ANSELMO-LIMA, WILMA T.; TAMASHIRO, EDWIN. Amoxicillin-clavulanate for patients with acute exacerbation of chronic rhinosinusitis: a prospective, double-blinded, placebo-controlled trial. INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY, v. 7, n. 2, p. 135-142, FEB 2017. (13/04148-2, 10/17580-1)