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Effect of anterior cruciate ligament rupture on the expression of genes and proteins related to atrophy in quadriceps muscle of rats

Abstract

The atrophy and weakness of the quadriceps muscle after rupture of the anterior cruciate ligament (ACL), present before and after its reconstruction, is an important limitation for rehabilitation, which restricts the early return of individuals to daily living activities and sports. These changes are related to failure on voluntary muscle activation resulting in a deficit of muscle strength. The molecular pathways involved in this process are not yet known. The identification of these pathways may provide therapeutic strategies to alleviate this situation. The neuromuscular electrical stimulation (NMES) is recommended to assist in the recruitment of motor units not voluntarily activated, favoring the maintenance of muscle activity. The hypotheses of this study are: a) the ACL injury activate genes associated with muscle atrophy, b) NMES applied to the quadriceps muscle after ACL injury atrophic alleviates this effect by modulating the expression of these genes. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
QUAGLIOTTI DURIGAN, JOAO LUIZ; PEVIANI, SABRINA MESSA; DELFINO, GABRIEL BORGES; DE SOUZA JOSE, REBECA JOMORI; PARRA, TALITA; SALVINI, TANIA FATIMA. Neuromuscular Electrical Stimulation Induces Beneficial Adaptations in the Extracellular Matrix of Quadriceps Muscle After Anterior Cruciate Ligament Transection of Rats. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, v. 93, n. 11, p. 948-961, NOV 2014. Web of Science Citations: 11.
DURIGAN, JOAO L. Q.; DELFINO, GABRIEL B.; PEVIANI, SABRINA M.; RUSSO, THIAGO L.; RAMIREZ, CAROLINA; DASILVA GOMES, ANDRE D. B.; SALVINI, TANIA F. NEUROMUSCULAR ELECTRICAL STIMULATION ALTERS GENE EXPRESSION AND DELAYS QUADRICEPS MUSCLE ATROPHY OF RATS AFTER ANTERIOR CRUCIATE LIGAMENT TRANSECTION. MUSCLE & NERVE, v. 49, n. 1, p. 120-128, JAN 2014. Web of Science Citations: 9.
DELFINO, GABRIEL B.; PEVIANI, SABRINA M.; DURIGAN, JOAO L. Q.; RUSSO, THIAGO L.; BAPTISTA, IGOR L.; FERRETTI, MARIO; MORISCOT, ANSELMO S.; SALVINI, TANIA F. Quadriceps Muscle Atrophy After Anterior Cruciate Ligament Transection Involves Increased mRNA Levels of Atrogin-1, Muscle Ring Finger 1, and Myostatin. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, v. 92, n. 5, p. 411-419, MAY 2013. Web of Science Citations: 12.

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