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Cell-mediated immune response in the colostrum and blood of neonate calves: influence of maternal vaccination against bovine viral diarrhea virus (BVDV)


The objective of this project is to evaluate the influence of maternal vaccination against BVDV in cell-mediated immune response in the colostrum and blood of neonate calves using the following assays: quantification of specific antibodies and cytokines by radioimmunoassay; detection of CD4 and CD8 lymphocyte populations and counting of gama delta TCR cells by flow cytometry; total leukocyte counts in blood and colostrum by automatic count and direct microscopy, respectively; differentiation of blood leukocytes by morphology in blood smears. Calves will be divided into two experimental groups of five animals each: group 1 (G1) calves fed colostrum of cows not vaccinated against BVDV, and group 2 (G2), calves fed colostrum of cows vaccinated against BVDV. Data distribution will be analyzed by Kolgomorov-Smirnov test. Analysis of variance will be used for data with parametric distribution; means will be compared by Duncan test. Variables with non-parametric distribution will be compared by Mann-Whitney test. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOMES, VIVIANI; BACCILI, CAMILA COSTA; DA COSTA E SILVA, CYNTHIA PEREIRA; CARDOSO PINTO, VIVIAN DA SILVA; SILVA, BRUNO TOLEDO; POZZI, CLAUDIA RODRIGUES; RIBEIRO, CLAUDIA PESTANA; PITUCO, EDVIGES MARISTELA. Humoral Immunity Assessment in Calves Born to Cows Immunized with Inactivated Vaccine for Bovine Herpesvirus 1 and Bovine Viral Diarrhea Virus. Acta Scientiae Veterinariae, v. 42, . (10/15865-9)
BACCILI, CAMILA COSTA; SOBREIRA, NATALIA MEIRELLES; SILVA, BRUNO TOLEDO; PITUCO, EDVIGES MARISTELA; GOMES, VIVIANI. Interface between Maternal Antibodies and Natural Challenge for Bovine Viral Diarrhea Virus (BVDV) in Holstein Heifers. Acta Scientiae Veterinariae, v. 44, . (10/15865-9)

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