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Functional correlation between mast cells and tumor angiogenesis

Grant number: 09/54013-0
Support Opportunities:Multi-user Equipment Program
Duration: February 01, 2011 - July 31, 2013
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Maria Célia Jamur
Grantee:Maria Célia Jamur
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
As informações de acesso ao Equipamento Multiusuário são de responsabilidade do Pesquisador responsável
EMU web page: Página do Equipamento Multiusuário não informada
Type of equipment: Tipo de Equipamento Multiusuário não informado
Manufacturer: Fabricante não informado
Model: Modelo não informado


In adult organisms, mast cells originate from the precursor cells present in the bone marrow, which migrate to peripheral tissues where they proliferate and mature. Recent studies have shown that these cells participate in pathological disorders of the nervous system, such as Alzheimer’s disease, and multiple sclerosis, as well as in cardiovascular diseases, such as congestive heart failure and neo-angiogenesis. Some researchers have observed an accumulation of mast cells at sites where tumor angiogenesis is occurring, which suggests that mast cells directly contribute to the process of formation of new blood vessels. Mast cells are involved with tumorigenesis and angiogenesis due to ther production of chemical mediators as well as of certain angiogenic factors (vascular endothelial growth factor, platelet-derived growth factor, and basic fibroblast growth factor) that have a chemotactic effect on the mast cells. The objective of our current project is to characterize the relationship between mast cells and the initial phases of tumor angiogenesis. Initially, we will investigate the mediators produced in this phase of angiogenesis, which are responsible for the recruitment of mast cells. Subsequently, we will evaluate whether the increase in the number of mast cells during angiogenesis correlates with tumor progression and whether mediators released by mast cells participate in this process. Preliminary results show that mast cells accumulate at the site where tumor formation initiates and play a role in this process by liberating histamine, chymase, and tryptase, producing cytokines (FGF-α, FGF-β, TGF-β, G-CSF) and metalloproteases. To confirm these results, we will perform in vitro assays using mast cell produced chemical mediators that can act selectively in the formation of blood vessels. The three-dimensional configuration of the blood vessels will be analyzed by scanning electron microscopy. This project will contribute to the development of new treatments to inhibit tumor angiogenesis and, consequently, tumor progression. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARCELINO DA SILVA, ELAINE ZAYAS; FREITAS-FILHO, EDISMAURO GARCIA; DE SOUZA-JUNIOR, DEVANDIR ANTONIO; PINTO DASILVA, LUIS LAMBERTI; JAMUR, MARIA CELIA; OLIVER, CONSTANCE. Adaptor protein-3: A key player in RBL-2H3 mast cell mediator release. PLoS One, v. 12, n. 3, . (14/11396-5, 13/12861-0, 09/54013-0)
BURANELLO, PATRICIA A. A.; BARBOSA-LORENZI, VALERIA C.; PINTO, MARCELO R.; PEREIRA-DA-SILVA, GABRIELA; BARREIRA, MARIA CRISTINA R. A.; JAMUR, MARIA CELIA; OLIVER, CONSTANCE. The lectin ArtinM activates RBL-2H3 mast cells without inducing degranulation. PLoS One, v. 15, n. 3, . (09/54013-0, 13/04088-0, 06/60642-2, 17/18618-1)
DE SOUZA JUNIOR, DEVANDIR ANTONIO; BORGES, ANTONIO CARLOS; SANTANA, ANA CAROLINA; OLIVER, CONSTANCE; JAMUR, MARIA CELIA. Mast Cell Proteases 6 and 7 Stimulate Angiogenesis by Inducing Endothelial Cells to Release Angiogenic Factors. PLoS One, v. 10, n. 12, . (11/10363-8, 09/54013-0)
FREITAS FILHO, EDISMAURO G.; DA SILVA, ELAINE Z. M.; ONG, HWEI LING; SWAIM, WILLIAM D.; AMBUDKAR, INDU S.; OLIVER, CONSTANCE; JAMUR, MARIA CELIA. RACK1 plays a critical role in mast cell secretion and Ca2+ mobilization by modulating F-actin dynamics. Journal of Cell Science, v. 134, n. 9, . (17/14645-4, 09/54014-7, 17/18618-1, 16/13228-8, 16/21988-2, 15/16673-0, 09/54013-0)
AMARU MAXIMIANO, WILLIAM MARCATTI; MARCELINO DA SILVA, ELAINE ZAYAS; SANTANA, ANA CAROLINA; DE OLIVEIRA, PAULO TAMBASCO; JAMUR, MARIA CELIA; OLIVER, CONSTANCE. Mast Cell Mediators Inhibit Osteoblastic Differentiation and Extracellular Matrix Mineralization. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, v. 65, n. 12, p. 723-741, . (12/06373-0, 16/50298-4, 09/54013-0)
AMARU MAXIMIANO, WILLIAM MARCATTI; MAZUCATO, VIVIAN MARINO; DE OLIVEIRA, PAULO TAMBASCO; JAMUR, MARIA CELIA; OLIVER, CONSTANCE. Nanotextured titanium surfaces stimulate spreading, migration, and growth of rat mast cells. Journal of Biomedical Materials Research Part A, v. 105, n. 8, p. 2150-2161, . (09/54013-0)

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