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Fundoscopic changes in diabetic dogs

Grant number: 11/07791-8
Support type:Regular Research Grants
Duration: August 01, 2011 - July 31, 2013
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:Angélica de Mendonça Vaz Safatle
Grantee:Angélica de Mendonça Vaz Safatle
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Aline Adriana Bolzan

Abstract

Diabetes mellitus is one of the most frequent endocrine disorders, characterized by relative or absolute of insulin, which can induces several ocular manifestations, among them diabetic retinopathy and cataract. Suddenly bilateral cataracts are the most common ocular manifestation in diabetic dogs resulting blindness, while in human beings, blindness is mainly caused by diabetic retinopathy. Diabetic Retinopathy is a microangiopathy that affects the precapillary, arterioles, capillaries, postcapillary venules, and the large vessels, causing them to be functionally and anatomically incompetent. This disease is classified into non-proliferative diabetic retinopathy (NPDR), preproliferative (PPDR) and proliferative (PDR). Microvascular changes result from loss of vascular tonus, altered blood flow, increased vascular permeability, edema, vascular obstruction, hemorrhage, retinal detachment. Hyperglycemia seems to be the most probably consequence of retinal damage, interfering in the cellular metabolism process and in transduction process. The fundoscopic findings comprehend microaneurysm, retinal venular dilatation and tortuosity, hyperreflectivity of tapetal area and chorioretinal exsudates. Because the cataract unable fundoscopic examination, the diagnosis of diabetic retinopathy in dogs is not completely elucidated, but suggest that disease is nonproliferative form. The aim of this study is to detect and follow-up the vascular changes by fundoscopic examination in diabetic dogs without ocular media opacities. Fifteen male and female diabetic dogs, aphakic and or not will be submitted to a fundoscopic and retinal photograph after pupil dilatation. Participants will be examined for 12 months and will have retinal photography perform each four months, and also the glycemia and fructosamine measurements will performed. The fundoscopic changes will be correlated with glycemic levels. The results will be reported and valued with the observed alterations. (AU)