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Effect of resistive and aerobic treatment on blood pressure, inflammatory activity and insulin sensitivity in hypertensive old individuals

Grant number: 10/19540-7
Support Opportunities:Regular Research Grants
Duration: June 01, 2011 - May 31, 2013
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Nereida Kilza da Costa Lima
Grantee:Nereida Kilza da Costa Lima
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated researchers:Eduardo Ferriolli ; Julio Cesar Moriguti ; Leandra Gonçalves Lima


The aging process promotes significant physiological and pathological changes. Understanding these changes becomes relevant as the elderly population is growing fast. In 2050 the number of sexagenarian will exceed people under 15 years in the world. Given this reality, it is necessary to promote healthy aging and improve the quality of life of older people, such as adopting a lifestyle more active. Among the changes associated with aging it is possible to mention: the increased pressure, decreased strength and skeletal muscle mass, decreased physical fitness, which is related to an increase in sedentary and weight gain, increased insulin resistance and chronic increase of inflammatory markers. Thus, physical activity should be encouraged for all elderly with a view to prevent and minimize changes caused by aging. The combination of aerobic exercise and resistance is helpful to healthy individuals. However, there is a lack of publications that evaluate the effect of aerobic training (AT) and resistance aerobic training (RAT) in hypertensive elderly population under drug therapy. The aim of this study will be to study the effect of AT and RAT in elderly hypertensive patients on blood pressure, serum levels of interleukin 6 (IL-6), tumor necrosis factor ± (TNF-±), insulin sensitivity, mass lean, fat percentage, body mass index, muscle strength, cardio-respiratory and serum lipids. We will study 36 patients of both sexes, between 60 and 75 years old, independent, in use of antihypertensive medications (hydrochlorothiazide, inhibitors of angiotensin-converting enzyme or angiotensin II receptor blockers), randomized to 3 groups: 12 weeks of AT, 12 weeks of AT and RAT, and control group with 12 weeks of mental activity in rest. Laboratory tests will be performed at the Hospital of the Faculty of Medicine of Ribeirão Preto. The training will take place in the Gymnasium Padovan, in the Ribeirão Preto city, Sao Paulo state. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LIMA, LEANDRA G.; BONARDI, JOSE T. M.; CAMPOS, GIULLIARD O.; BERTANI, RODRIGO F.; SCHER, LURIA M. L.; MORIGUTI, JULIO C.; FERRIOLLI, EDUARDO; LIMA, NEREIDA K. C.. Combined aerobic and resistance training: are there additional benefits for older hypertensive adults?. Clinics, v. 72, n. 6, p. 363-369, . (10/19540-7)

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