Bioinformatics for high-throughput sequencing

• Grant number: 11/07776-9
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2011
• End date: June 30, 2012
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: François Marie Artiguenave
• Grantee: François Marie Artiguenave
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The recent advent of the second "next generation sequencing" (NGS) technologies has had two major consequences: a dramatic increase in the speed and ease of acquisition of massive amount of sequence data, and a spectacular decrease in the cost of sequencing. Moreover, the limitations still encountered should be soon overcome by the third generation providing single molecule sequencing generating long read. Many biological phenomenon involving nucleic acids are now tractable by sequencing approaches and a large number of projects that would have been considered not long ago as far too costly or too ambitious are now eligible to analysis. This is particularly true in medical researches where NGS are opening perspectives in different disciplines, from genetics to functional understanding of molecular basis of diseases. In this context, the main objective of this proposal is to enable the Faculty of Medical Sciences of Unicamp to develop research based on new data acquisition technologies. (AU)