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Depression and alcohol abuse among patients with acute coronary syndrome: prospective evaluation in the ERICO study (Strategy of Registry of Coronary Heart Disease)

Grant number: 11/07670-6
Support Opportunities:Regular Research Grants
Duration: July 01, 2011 - June 30, 2013
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Alessandra Carvalho Goulart
Grantee:Alessandra Carvalho Goulart
Host Institution: Hospital Universitário (HU). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers: Abner Morilha ; Andre Russowsky Brunoni ; Isabela Judith Martins Bensenor ; Paulo Andrade Lotufo


The occurrence of major depressive disorder after an acute coronary disease may represent an independent marker of poor prognosis. We propose, therefore, to evaluate the relationship between depression and alcohol abuse in a sample of patients with acute coronary syndrome (ACS). Methodology: This is an ancillary project linked to the ERICO study (Strategy of Registry of Coronary Heart Disease), which began in February 2009 and, it is still ongoing at the Hospital Universitário of the University of São Paulo. In the ERICO study are characterized the subtypes of ACS (unstable angina, acute myocardial infarction without ST elevation and acute myocardial infarction with ST elevation), predictors of classic cardiovascular risk, the quality of hospital care and the rates of fatal and non-fatal events, as well as, it is applied a brief screening questionnaire for depression (Patient Health Questionnaire - PHQ 9) at hospital admission. As part of this subproject, the 30 day follow-up visit, the patient will be submitted to an extended evaluation for major depressive disorder, depressive symptoms and alcohol abuse through the following instruments: Patient Health Questionnaire - PHQ-2 and PHQ-9, Hamilton scale (Depression Rating Scale, HDRS-31), Beck Depression Inventory (BDI), assessment for abuse and alcohol dependence (AUDIT, CAGE), questionnaire for quality of life (Short Form-36). In 180 days, we will reapply the PHQ 2 and 9, the BDI and the AUDIT through telephone interview. The baseline characteristics will be compared by sex and depression diagnoses (major depression or depressive symptoms mild, moderate and severe) and alcohol abuse. Associations between depression, as well as, abuse / alcohol dependence, and fatal and nonfatal cardiovascular events will be performed by logistic regression. (AU)

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