| Grant number: | 11/10823-9 |
| Support Opportunities: | Regular Research Grants |
| Field of knowledge: | Biological Sciences - Biochemistry - Chemistry of Macromolecules |
| Principal Investigator: | Vani Xavier de Oliveira Junior |
| Grantee: | Vani Xavier de Oliveira Junior |
| Host Institution: | Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil |
| Associated researchers: | Erick Leite Bastos ; Luiz Francisco Monteiro Leite Ciscato ; Marcos Leoni Gazarini Dutra ; Margareth de Lara Capurro-Guimarães ; Wendel Andrade Alves |
Abstract
Malaria affects 300 million people annually. Nevertheless, this disease has neither an effective drug treatment nor an appropriate preventive. Our research group has showed a new perspective to strive against this disease, when we related the anti-sporozoite action of angiotensin II (AII) and its inhibitory effect on the development of Plasmodium gallinaceum in Aedes aegypti. Recently, we have described the synthesis of some analogues more active than AII, which not present the pressure activity of this hormone. However, these compounds are not able to wipe out totally the parasites and rmoreover, are still susceptible to enzymatic degradation.The objective of this multidisciplinary project is obtaining an effective drug to prevent and combat the malaria. Thus, we propose the synthesis of new peptides and antimalarial prodrugs, which were designed to be employed in different evolutionary cycles of the parasite.In addition, this study aims to increase the molecular stability of these compounds against proteases, which would result in a longer action of these drugs, as well as realizing a research about the synergetic effects of drugs known in this class of bioactive peptides.The peptides will be synthesized using solid phase method, purified by RP-HPLC and characterized by different analytical techniques. In the biological assays will be verified: the molecular stability of this compound and its lytic ability "in vitro", using mature sporozoites (P. gallinaceum), collected from salivary glands of mosquito infected. Besides that, the antimalarial effects in different evolutionary steps of the parasite and its types of strains (P. falciparum and P.chabaudi) will be evaluated. (AU)
| Articles published in Agência FAPESP Newsletter about the research grant: |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |