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Influence of changes of sleep in sensory-motor control and systemic inflammatory response in patients with knee osteoarthritis of grade I or II

Grant number: 11/06619-7
Support type:Regular Research Grants
Duration: October 01, 2011 - September 30, 2013
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Stela Márcia Mattiello
Grantee:Stela Márcia Mattiello
Home Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Assoc. researchers:Andressa da Silva de Mello ; Lia Rita Azeredo Bittencourt
Associated scholarship(s):11/19113-4 - Influence of changes of sleep in sensory-motor control and systemic inflammatory response in patients with knee osteoarthritis of grade I or II, BP.TT

Abstract

Osteoarthritis (OA) is one of the major health problems and its prevalence has increased in recent decades. It has been shown that OA causes negative effects on sleep and sleep disorders that these seem to be correlated with the function and physical performance of patients with OA. However, no study to date has demonstrated the effects of sleep disturbances in sensorimotor control and systemic inflammatory response in patients with OA. Thus, the purpose of this study is to assess the influence of sleep disturbances in sensorimotor control (postural and neuromuscular control) and inflammatory markers (cytokines) in patients with knee OA grade I or II. Participate in this study 60 male volunteers, aged between 40 and 65. These volunteers will be divided into four groups: Group 1 (n = 15): Osteoarthritis and good quality sleep, Group 2 (n = 15): Osteoarthritis and poor sleep quality, Group 3 (n = 15): Without good and Osteoarthritis sleep quality, and Group 4 (n = 15): Without Osteoarthritis and poor sleep quality. All volunteers will hold a polysomnography to detect the presence or not of sleep. Test will be performed on the isokinetic dynamometer to evaluate the time of acceleration, maximum isometric and isokinetic concentric and eccentric maximum quadriceps muscle and a strength test to assess submaximal neuromuscular control. There will also be a test on a force plate to measure postural control and bipedal uni, but also respond to the WOMAC questionnaire that assesses the quality of life in patients with OA. Blood will be collected for analysis of inflammatory cytokines (TNF-alpha, IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, IL-10, TGF-beta). The level of significance is 5% (p d 0.05).OuvirLer foneticamente (AU)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, ANDRESSA; MELLO, MARCO TULIO; SERRAO, PAULA REGINA; LUZ, ROBERTA PITTA; RUIZ, FRANCIELE; BITTENCOURT, LIA RITA; TUFIK, SERGIO; MATTIELLO, STELA MARCIA. Influence of Obstructive Sleep Apnea in the Functional Aspects of Patients With Osteoarthritis. JOURNAL OF CLINICAL SLEEP MEDICINE, v. 14, n. 2, p. 265-270, 2018. Web of Science Citations: 1.
SILVA, ANDRESSA; MELLO, MARCO T.; SERRAO, PAULA R.; LUZ, ROBERTA P.; BITTENCOURT, LIA R.; MATTIELLO, STELA M. Influence of obstructive sleep apnea syndrome in the fluctuation of the submaximal isometric torque of knee extensors in patients with early-grade osteoarthritis. BRAZILIAN JOURNAL OF PHYSICAL THERAPY, v. 19, n. 4, p. 271-278, JUL-AUG 2015. Web of Science Citations: 1.
ANDRESSA SILVA; MARCO TÚLIO DE MELLO; SEBASTIÃO AUGUSTO GÁVEA JUNIOR; SANDRA SOUZA DE QUEIROZ; SERGIO TUFIK; STELA MÁRCIA MATTIELLO. Therapeutic modalities and postural balance of patients with knee osteoarthritis: systematic review. Fisioter. mov., v. 28, n. 3, p. 605-616, Set. 2015.
SERRAO, PAULA REGINA M. S.; VASILCEAC, FERNANDO A.; GRAMANI-SAY, KARINA; LESSI, GIOVANNA C.; REIFF, RODRIGO B. M.; MATTIELLO-SVERZUT, ANA CLAUDIA; MATTIELLO, STELA M. Expression of receptors of advanced glycation end product (RAGE) and types I, III and IV collagen in the vastus lateralis muscle of men in early stages of knee osteoarthritis. Connective Tissue Research, v. 55, n. 5-6, p. 331-338, OCT-DEC 2014. Web of Science Citations: 1.
SERRAO, PAULA R. M. S.; GRAMANI-SAY, KARINA; LESSI, GIOVANNA C.; MATTIELLO, STELA M. Knee extensor torque of men with early degrees of osteoarthritis is associated with pain, stiffness and function. BRAZILIAN JOURNAL OF PHYSICAL THERAPY, v. 16, n. 4, p. 289-294, JUL-AUG 2012. Web of Science Citations: 17.

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