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Physical and chemical properties of LDL and HDL, cardiometabolic and oxidative markers can be modulate by consumption of ômega-3, ômega-6 e ômega-9 in adult subjects?

Grant number: 11/12523-2
Support type:Regular Research Grants
Duration: September 01, 2011 - August 31, 2013
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Nágila Raquel Teixeira Damasceno
Grantee:Nágila Raquel Teixeira Damasceno
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Antonio Martins Figueiredo Neto ; Dulcineia Saes Parra Abdalla ; Magnus Ake Gidlund ; Raul Cavalcante Maranhao ; Sayuri Miyamoto

Abstract

Cardiovascular diseases are the leading cause of morbidity and mortabilidade worldwide, and its prevalence more accelerated in countries with low and middle income. Despite the reduction in the number of deaths after the discovery of statins, approximately 5% of patients develop adverse effects the use of these drugs, which contraindicate its continued use. Beyond addition, approximately 30% of individuals on statin use remains moderate or high cardiovascular risk. Therefore, changes in style life, and especially in the diet are an important tool in modification of risk factors and, possibly, prevention of events clinicians. In this sense, the use of different fatty acids is potentially interesting intervention, as previously documented in the literature. Despite this fact, the simultaneous evaluation of the effect of omega-3 fatty acids, omega-6 and omega-9 on the physico- chemical, oxidative and cardiometabolic is still little explored in literature and absent in the Brazilian population. The purpose of this study is to evaluate the structural changes of LDL and HDL, as well as cardiometabolic parameters in adults and oxidative underwent intervention with omega-3 omega-6 or omega-9. To this end, will be recruited 400 subjects with cardiovascular risk classified second score of the Framingham risk These individuals will be distributed groups: W-3 (n = 100, 6.0 g / d of fish oil), W-6 (n = 100, 6.0 g / d Sunflower oil - a source of omega-6), W-9 (n = 100, 6.0 g / d of oil Olive - a source of omega 9) and Placebo (n = 100, 6.0 g / d of gelatin). On baseline, 4 and 8 weeks will be assessed the acute effect of interventions on the following parameters: lipid profile and apolipoproteins, LDL and HDL size, fat-soluble antioxidants, oxidation products [LDL (-), LDL (-)], anti-inflammatory markers (CRP and Lp-PLA2), NEFAs, CETP and glucose metabolism (glucose and insulin). Are also monitored the clinical profile, family history of diseases, food consumption, physical activity and parameters anthropometric. Adherence to the intervention will be evaluated by structured questionnaire and biochemical markers. The development of this study aimed at the following outcomes: Primary - Change the physicochemical properties of LDL and HDL, the marcardores cardiometabolic and oxidative. Secondary - Lipid profile, glucose metabolism, anthropometry and body composition. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PRUPER DE FREITAS, MARIA CAMILA; ESTEVEZ FERNANDEZ, DIANA GABRIELA; COHEN, DANIELLE; FIGUEIREDO-NETO, ANTONIO MARTINS; MARANHAO, RAUL CAVALCANTE; TEIXEIRA DAMASCENO, NAGILA RAQUEL. Oxidized and electronegative low-density lipoprotein as potential biomarkers of cardiovascular risk in obese adolescents. Clinics, v. 73, 2018. Web of Science Citations: 1.
DE ARAUJO LIMA BARBOSA, MILENA MARIA; TRINANES RAPOSO, ALEXANDRA LORENZZI; TEIXEIRA DAMASCENO, NAGILA RAQUEL. The benefits of omega-3 supplementation depend on adiponectin basal level and adiponectin increase after the supplementation: A randomized clinical trial. NUTRITION, v. 34, p. 7-13, FEB 2017. Web of Science Citations: 8.
CARTOLANO, FLAVIA DE C.; DIAS, GABRIELA D.; DE FREITAS, MARIA C. P.; FIGUEIREDO NETO, ANTONIO M.; DAMASCENO, NAGILA R. T. Insulin Resistance Predicts Atherogenic Lipoprotein Profile in Nondiabetic Subjects. JOURNAL OF DIABETES RESEARCH, 2017. Web of Science Citations: 7.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.