Advanced search
Start date

Candida parapsilosis: molecular characterization, biofilm formation and sensitivity to antifungal agents.

Grant number: 11/11854-5
Support Opportunities:Regular Research Grants
Duration: September 01, 2011 - August 31, 2012
Field of knowledge:Biological Sciences - Microbiology
Principal Investigator:Claudete Rodrigues Paula Gandra
Grantee:Claudete Rodrigues Paula Gandra
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers: Eriques Gonçalves da Silva ; Luciana da Silva Ruiz Menezes


Isolates of C. parapsilosis has been reported to be physiologically indistinguishable, but genetically heterogeneous. It has been suggested that C. parapsilosis is a complex composed of three genetically distinct groups, based on this analysis relet through molecular techniques relevant. It was proposed then that each of the three groups was considered a new species, named as C. parapsilosis, C. orthopsilosis and C. metapsilosis.Neste context, little is known about the frequency of C. orthopsilosis and C. metapsilosis in yeast strains isolated from blood cultures. Few studies in the literature provide sufficient data to assess the prevalence of these three species in bloodstream infections, infections in other sites or even colonization. The genetic differentiation among these species may represent different behaviors in the face of antifungal therapy or may be responsible for different clinical pictures. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list using this form.