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Effect of isolated vicilins from Glycine max, Vigna unguiculata e Vigna angularis on the cholesterol metabolism in rats

Grant number: 11/11779-3
Support type:Regular Research Grants
Duration: October 01, 2011 - September 30, 2013
Field of knowledge:Agronomical Sciences - Food Science and Technology
Principal Investigator:Valdir Augusto Neves
Grantee:Valdir Augusto Neves
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Assoc. researchers:Aureluce Demonte ; Cleslei Fernando Zanelli


A number of studies have pointed to protein function as a biologically active agent in addition to its well-known nutritional role. In turn, the proteins of some legumes have received special attention due to their involvement in metabolism and prevention of lipid disorders, especially hypercholesterolemia, hypertriglyceridemia and hyperglycemia. Different approaches have shown an association of 7S globulin (vicilin) of soybean to certain changes in lipid metabolism in animals and humans. On the other hand, a certain similarity between vicilin from different species with respect to compositional characteristics, the amino acid sequence and properties have been registered. Thus, this project proposes to investigate the action of the protein of vicilin-type isolated from species Glycine max., Vigna angularis and V. unguiculata on lipid metabolism in animals subjected to a hypercholesterolemic diet. Male Wistar rats will be divided into nine experimental groups (n = 9). A control group (STD) will receive a standard diet (AIN-93), a second group (HC) will receive a hypercholesterolemic diet (HC), and other groups submitted to HC diet will be given different daily doses of the proteins isolated and administered by gavage, the last group will be treated with 50mg / kg body weight / day of a lipid-lowering drug (simvastatin). It will be analyzed: growth parameters, feed intake, fecal excretion and fat deposition and associated with lipid metabolism; as well as serum, fecal and liver total cholesterol, triglycerides and lipoprotein fractions and enzyme activity of HMG-CoA (HMG-CoA reductase) . It is hoped that the study will contribute to greater understanding of the possible effects and their mechanisms of action, as well as in its consequences can lead to aggregation of benefits in response to public health issues and social-economic sector. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA, EDERLAN S.; AMARAL, ANA LUCIA S.; DEMONTE, AURELUCE; ZANELLI, CLESLEI F.; CAPRARO, JESSICA; DURANTI, MARCELLO; NEVES, VALDIR A. Hypocholesterolaemic effect of rat-administered oral doses of the isolated 7S globulins from cowpeas and adzuki beans. JOURNAL OF NUTRITIONAL SCIENCE, v. 4, FEB 16 2015. Web of Science Citations: 11.

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