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The impact of body fat excess on bone densitometry and bone metabolims biomarkers: a study with overweight, obese and superobese adolescents

Grant number: 11/05991-0
Support type:Regular Research Grants
Duration: October 01, 2011 - September 30, 2013
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Tamara Beres Lederer Goldberg
Grantee:Tamara Beres Lederer Goldberg
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Assoc. researchers: Anapaula da Conceição Bisi Rizzo ; Carla Cristiane Silva ; Cilmery Suemi Kurokawa ; Luciana Nunes Mosca

Abstract

Considering that obesity and osteoporosis are pathologies that affect the general population, that they are severe public health problems, that obesity has been observed at increasingly earlier ages and that, with survival increase, population ageing results in increased prevalence of osteopenia/osteoporosis and their consequent fractures, this project aims at evaluating the relationship between fat mass excess on bone mineral densitometry and on bone formation and resorption biomarkers in adolescents of both genders. To that end, an evaluation of Bone Mineral Density (BMD), conducted on the Lumbar Spine (L1-L4), Proximal Femur and Total Body, will be used to clarify the possible effect of body fat excess on bone mass gain in adolescents of both genders aged 10 to 20 years (incomplete) by relating the results to bone formation biomarker, such as Osteocalcin (OC), and to bone resorption biomarkers (S-CTx).Methods: Adolescents aged 10 to 19 years and registered as new cases at the Adolescents' Health Outpatient Unit of the Botucatu School of Medicine - UNESP will be clinically and nutritionally evaluated. Their weight and stature will be measured, and their Body Mass Index (BMI) will be estimated. The obtained data will be compared to the Curves of the National Center for Health Statistics (CDC, 2002). Those showing BMI between 85o and <95o percentile will be regarded as overweight, and those equal to or above the 95o percentile will be regarded as obese. The evaluation of secondary sex characteristics will be performed by a qualified professional, and the result will be classified according to Tanner stages (Marshall & Tanner, 1969). A food enquiry will be conducted by using a 3-day recall. Next, those considered to be overweight or obese will be invited to undergo a Bone Mineral Density evaluation (BMD g/cm2) by dual energy X-ray absormetry (DXA) bone densitometry obtained on the Lumbar Spine (L1-L4), Proximal Femur and Total Body, and to Bone Age determination. Additionally, by the subjects' fasting for at least 10 hours and as long as they agree to the procedure, venipuncture will be performed for blood collection. Blood will be centrifuged according to recommended guidelines for the collection of serum which will be immediately stored in a freezer at -70o for the later dosage of specified bone markers. Such procedures will only be performed after agreement by the adolescents and their guardians, following the reading and signature of an Informed Consent Statement. The project has been submitted to and approved by the institution's Research Ethics Committee. Sample size estimation determined that 300 adolescents, 150 for each gender, must be evaluated. The data will be analyzed by age range groups and characterized by descriptive statistics, means, medians, standard deviations, quartiles and maximum and minimum limits of each variable. Sequentially, Analysis of Variance will be performed for comparison between all age ranges, according to the nutritional classification based on BMI. Also, the Tukey test will be performed in order to find significant differences, with p<0.05. Spearman's correlation coefficients will be obtained between bone biomarkers and the BMD results in the three evaluated sites. (AU)

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANAPAULA DA CONCEIÇÃO BISI RIZZO; TAMARA BERES LEDERER GOLDBERG; TALITA POLI BIASON; CILMERY SUEMI KUROKAWA; CARLA CRISTIANE DA SILVA; JOSÉ EDUARDO CORRENTE; HELIO RUBENS CARVALHO NUNES. One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives. Jornal de Pediatria, v. 95, n. 5, p. 567-574, Set. 2019. Web of Science Citations: 0.
MOSCA, L. N.; GOLDBERG, T. B. L.; DA SILVA, V. N.; KUROKAWA, C. S.; RIZZO, A. C. B.; DA SILVA, C. C.; DOS SANTOS TEIXEIRA, A.; CORRENTE, J. E. The impact of excess body fat on bone remodeling in adolescents. OSTEOPOROSIS INTERNATIONAL, v. 28, n. 3, p. 1053-1062, MAR 2017. Web of Science Citations: 0.
DA SILVA, VALERIA NOBREGA; MOSCA FIORELLI, LUCIANA NUNES; DA SILVA, CARLA CRISTIANE; KUROKAWA, CILMERY SUEMI; LEDERER GOLDBERG, TAMARA BERES. Do metabolic syndrome and its components have an impact on bone mineral density in adolescents?. NUTRITION & METABOLISM, v. 14, JAN 4 2017. Web of Science Citations: 9.
BIASON, TALITA POLI; LEDERER GOLDBERG, TAMARA BERES; KUROKAWA, CILMERY SUEMI; MORETTO, MARIA REGINA; TEIXEIRA, ALTAMIR SANTOS; DE CARVALHO NUNES, HELIO RUBENS. Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period. BMC Endocrine Disorders, v. 15, APR 3 2015. Web of Science Citations: 9.
DA SILVA, VALERIA NOBREGA; LEDERER GOLDBERG, TAMARA BERES; MOSCA, LUCIANA NUNES; BISI RIZZO, ANAPAULA DA CONCEICAO; TEIXEIRA, ALTAMIR DOS SANTOS; CORRENTE, JOSE EDUARDO. Metabolic syndrome reduces bone mineral density in overweight adolescents. BONE, v. 66, p. 1-7, SEP 2014. Web of Science Citations: 7.
MOSCA, LUCIANA NUNES; GOLDBERG, TAMARA BERES LEDERER; DA SILVA, VALERIA NOBREGA; DA SILVA, CARLA CRISTIANE; KUROKAWA, CILMERY SUEMI; BISI RIZZO, ANAPAULA C.; CORRENTE, JOSE EDUARDO. Excess body fat negatively affects bone mass in adolescents. NUTRITION, v. 30, n. 7-8, p. 847-852, JUL-AUG 2014. Web of Science Citations: 35.
MOSCA, LUCIANA NUNES; DA SILVA, VALERIA NOBREGA; LEDERER GOLDBERG, TAMARA BERES. Does Excess Weight Interfere with Bone Mass Accumulation during Adolescence?. NUTRIENTS, v. 5, n. 6, p. 2047-2061, JUN 2013. Web of Science Citations: 23.
RIZZO, ANAPAULA C. B.; GOLDBERG, TAMARA B. L.; SILVA, CARLA C.; KUROKAWA, CILMERY S.; NUNES, HELIO R. C.; CORRENTE, JOSE E. Metabolic syndrome risk factors in overweight, obese, and extremely obese brazilian adolescents. NUTRITION JOURNAL, v. 12, JAN 30 2013. Web of Science Citations: 28.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.