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Histological evaluation of tooth replantation after pinealectomy in rats

Grant number: 11/09352-1
Support type:Regular Research Grants
Duration: October 01, 2011 - September 30, 2013
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal researcher:Celso Koogi Sonoda
Grantee:Celso Koogi Sonoda
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil
Assoc. researchers:Doris Hissako Matsushita


To result in serious damage to the periodontal ligament avulsion dental trauma can lead to tooth loss as a result of root resorption. In order to improve the prognosis of replanted teeth several factors have been studied and seeking the development of a treatment protocol. However little has been studied in relation to systemic factors. One such condition is the absence of melatonin, which can occur in people with nocturnal habits. Because this hormone can interfere with the metabolism of connective tissue and bone has been proposed to study the repair process of tooth replantation in rats pinealectomized. For that will be used 30 mice divided into 3 groups of 10 animals. In group I animals should be subjected to immediate replantation of the maxillary central incisor. In group II, animals should be subjected to pinealectomy (PNX) and then to immediate tooth replantation. In group III (sham), animals should be subjected to exposure of the pineal gland, but without removing it, and then to immediate tooth replantation. After 60 days, the animals will be euthanized and specimens containing the teeth will be processed for obtaining slides to be stained with hematoxylin and eosin for histomorphologic analysis. Will be analyzed and quantified the occurrence of inflammatory resorption, resorption subsitution and areas of ankylosis. The data are converted into scores for statistical analysis. (AU)

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