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In vitro expression of adhesion molecules on in situ like malignant areas


In order to occur the neoplastic progression, it is required the occurrence of several genetic and epigenetic events, including the overexpression of molecules that regulate cell growth, proliferation, motility and invasion to surround tissues, as well as cell surface receptors and adhesion molecules alterations which regulate cell-cell and cell-extracellular matrix interactions. Some studies have emphasized the importance of myoepithelial cells in the neoplasms behavior, highlighting its role as a tumor suppressor by promoting important defense against the cancer invasion. Considering an in vitro model of the tumorigenesis process and based in our previous studies, the aim of this study is to analyse cell-cell and cell-matrix interactions on sites that mimic an in situ situation when malignant squamous cell are surrounded by benign myoepithelial cells from pleomorphic adenoma, under the influence of fibronectin substratum at different periods of cell culture. The purpose of this investigation is identifying the moment of integrins (alpha5beta1, alpha5beta6), E-cadherin and/beta-catenin expression during the neoplastic process by indirect immunofluorescence. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARTINEZ, ELIZABETH FERREIRA; DIAS DEMASI, ANA PAULA; NAPIMOGA, MARCELO HENRIQUE; BARCELLOS SILVA, CAROLINA AMALIA; NAVARINI, NATALIA FESTUGATTO; ARAUJO, NEY SOARES; DE ARAUJO, VERA CAVALCANTI. Myoepithelial cells from pleomorphic adenoma are not influenced by tumor conditioned media from breast ductal adenocarcinoma and melanoma cells: An in vitro study. Oncology Letters, v. 9, n. 1, p. 313-317, JAN 2015. Web of Science Citations: 0.
MARTINEZ, ELIZABETH FERREIRA; NAPIMOGA, MARCELO HENRIQUE; MARTINS MONTALLI, VICTOR ANGELO; DE ARAUJO, NEY SOARES; DE ARAUJO, VERA CAVALCANTI. In vitro cytokine expression in in situ-like areas of malignant neoplasia. ARCHIVES OF ORAL BIOLOGY, v. 58, n. 5, p. 552-557, MAY 2013. Web of Science Citations: 6.

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