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Influence of low intensity laser and biomimetic treatment on osseointegration: histological and biomechanical analyses in rabbits

Abstract

The present study will evaluate the in vivo osteogenesis in commercial implants, subjected or not to biomimetic treatment (BT), associated or not with laser therapy (LLLT) by means of histological and histomorphometric analyses, and removal torque-testing. In this study, 100 treated surface implants trademarked by the National Implants System (SIN) will be used, which will be divided into four groups a) Group 1: control group, b) Group 2: implant submitted to BT, c) Group 3: implant + LLLT d) Group 4: implant submitted to BT + LLLT. These implants will be inserted in 25 New Zealand rabbits, which will receive an implant of each group. Laser therapy will be performed with low intensity laser (Aluminum-Gallium Arsenide semiconductor- ArGaAl) using 100 mW power parameters in continuous mode, 808 nm wavelengths and 23 J/cm2 of energy density. Prior to surgery, the surface of four implants submitted to BT will be characterized by energy dispersive spectroscopy (EDS). Fifteen rabbits will be used to evaluate and compare the repair of bone tissue surrounding the implants by means of histological and histomorphometric analyses. The animals will be put down 01, 02 and 06 weeks after surgery, yielding a total of five rabbits per period. Ten rabbits will be used to quantify the union present in the bone-implant interface by means of torque removal testing. The animals will be put down 02 and 06 weeks after surgery, yielding a total of five rabbits per period. The data from histomorphometric analysis and torque testing will be evaluated by the ANOVA statistical test and Tukey test (p <0.05). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LIMA VILLACA-CARVALHO, MARIA FERNANDA; RIBEIRO DE ARAUJO, JULIANI CAROLINE; BERALDO, JULIANA MARIANO; DO PRADO, RENATA FALCHETE; LEONELLI DE MORAES, MARI ELI; COUTINHO MANHAES JUNIOR, LUIZ ROBERTO; CODARO, EDUARDO NORBERTO; ACCIARI, HELOISA ANDREA; BARROS MACHADO, JOAO PAULO; REGONE, NATAL NERIMIO; LOBO, ANDERSON OLIVEIRA; MARCIANO, FERNANDA ROBERTA; REIS DE VASCONCELLOS, LUANA MAROTTA. Bioactivity of an Experimental Dental Implant with Anodized Surface. JOURNAL OF FUNCTIONAL BIOMATERIALS, v. 12, n. 2 JUN 2021. Web of Science Citations: 0.
DO PRADO, RENATA FALCHETE; EL ABRAS ANKHA, MILAGROS DEL VALLE; GRITI BUENO, DAIANE ACACIA; DE SOUZA SANTOS, EVELYN LUZIA; PEREIRA TINI, ITALO RIGOTTI; RAMOS, CAROLINA JUDICA; SPALDING, MARIANNE; OLIVEIRA DE VASCONCELLOS, LUIS GUSTAVO; REIS DE VASCONCELLOS, LUANA MAROTTA. CaP Coating and Low-Level Laser Therapy to Stimulate Early Bone Formation and Improve Fixation of Rough Threaded Implants. IMPLANT DENTISTRY, v. 27, n. 6, p. 660-666, DEC 2018. Web of Science Citations: 1.

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