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Impact of pharmaceutical care on management of uncontrolled hypertension in elderly patients with Diabetes Mellitus type II

Grant number: 11/11145-4
Support type:Regular Research Grants
Duration: December 01, 2011 - November 30, 2013
Field of knowledge:Health Sciences - Pharmacy
Principal researcher:Silvia Storpirtis
Grantee:Silvia Storpirtis
Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Despite evidence showing that antihypertensive treatment is effective in the reduction of cardiovascular morbidity and mortality, the rate control of blood pressure (BP) remains inadequate for most affected individuals. This situation could potentially be exacerbated in the presence of associated medical conditions such as Diabetes Mellitus. Thus, this study aims to assess the impact of pharmaceutical care on management of uncontrolled hypertension in elderly patients with diabetes mellitus type II. We'll be conducting a randomized clinical trial in the clinic of Metabolic Diseases, University Hospital, University of São Paulo. This study will include a random sample of 152 patients with a diagnosis of essential hypertension and diabetes mellitus type II, both genders, aged between 60 and 75 years and BP >130/80 mmHg. The patient consultation will consist of a 40-50 minutes face-to-face interview, over 10 months (March to December/2012). The pharmacists' interventions will be focused on health care education and monitoring of drug-related problem. The main outcome measures include: clinical (BP, body mass index, waist circumference, and medication adherence); humanistic (quality of life and patient satisfaction) and economic (use of healthcare resources). It is expected that the pharmaceutical care service can optimize drug therapy, reduce the cardiovascular morbidity and mortality, promoting satisfaction and quality of life for elderly patients with hypertension and diabetes mellitus. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AGUIAR, PATRICIA M.; DA SILVA, CLAUDIO HENRIQUE P.; CHIANN, CHANG; DOREA, EGIDIO LIMA; LYRA, JR., DIVALDO P.; STORPIRTIS, SILVIA. Pharmacist-physician collaborative care model for patients with uncontrolled type 2 diabetes in Brazil: results from a randomized controlled trial. JOURNAL OF EVALUATION IN CLINICAL PRACTICE, v. 24, n. 1, SI, p. 22-30, FEB 2018. Web of Science Citations: 4.
AGUIAR, PATRICIA MELO; BRITO, GISELLE DE CARVALHO; LIMA, TACIO DE MENDONCA; ALVES LIMA SANTOS, ANA PATRICIA; LYRA, JR., DIVALDO PEREIRA; STORPIRTIS, SILVIA. Investigating Sources of Heterogeneity in Randomized Controlled Trials of the Effects of Pharmacist Interventions on Glycemic Control in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis. PLoS One, v. 11, n. 3 MAR 10 2016. Web of Science Citations: 14.
AGUIAR, PATRICIA MELO; BRITO, GISELLE DE CARVALHO; CORRER, CASSYANO JANUARIO; LYRA JUNIOR, DIVALDO P.; STORPIRTIS, SILVIA. Exploring the Quality of Systematic Reviews on Pharmacist Interventions in Patients With Diabetes: An Overview. ANNALS OF PHARMACOTHERAPY, v. 48, n. 7, p. 887-896, JUL 2014. Web of Science Citations: 16.

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