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Evaluation of dialytical complications in akute kidney injury patients treated with different time of prolonged hemodialysis

Grant number: 11/19419-6
Support Opportunities:Regular Research Grants
Duration: December 01, 2011 - November 30, 2013
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Daniela Ponce
Grantee:Daniela Ponce
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


The high mortality rate among critically ill acute kidney injury (AKI) patients remains an unsolved problem in spite of the technological advances in renal replacement therapy. Critical AKI patients should be treated with continuous venovenous therapies or prolonged hemodialysis. There is no evidence that one method is better than other concerning survival patients and metabolic control. One session of prolonged hemodialysis can have as duration from 6 to 18 hours. There are not studies that compared dialytical complications in different duration sessions of prolonged hemodialysis. The aim of this study was to evaluate 120 critical AKI patients treated with different duration sessions of prolonged hemodialysis (60 patients treated with sessions of 6 hours duration and 60 patients treated with sessions of 10 h of duration). This is a randomized study and hemodialysis prescription will be performed by nephrologist. After each dialysis session, clinical and lab evaluation will be performed. The hemodialysis will be interruped when there will be recovery of kidney function, change of dialytic method, no recovery of kidney function after 30 days of dialysis treatment or patients death. Different statistical tests will be used to evaluate and compare the groups, considering p<0.05. (AU)

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