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Hormone replacement therapy in the prostate of UChB rat: hormone receptors and inflammatory proteins expression

Grant number: 11/05936-9
Support type:Regular Research Grants
Duration: February 01, 2012 - January 31, 2014
Field of knowledge:Biological Sciences - Morphology
Principal Investigator:Francisco Eduardo Martinez
Grantee:Francisco Eduardo Martinez
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Assoc. researchers:Beatriz Aparecida Fioruci Fontanelli ; Leonardo de Oliveira Mendes ; Luiz Gustavo de Almeida Chuffa ; Patricia Fernanda Felipe Pinheiro ; Raquel Fantin Domeniconi ; Wagner José Fávaro ; Wellerson Rodrigo Scarano


Excessive alcohol consumption and its consequences arising from their use have reached alarming proportions around the world. Researches have focused on the morphological and functional changes of ethanol upon the male reproductive system, however most studies remain inconclusive when regarding to the possible inflammatory effects caused by the ethanol in several tissues, include reproductive. The prostate is hormone-dependent, in which is regulated mainly by androgens and estrogens. Several factors, such as aging and obesity, promote hormonal disturbances triggering inflammatory reactions. Ethanol itself causes a decrease of testosterone concentration, but it is still unknown the inflammatory repercussions on the prostate. Therefore, this study aims to examine the ethanol action on the expression of inflammatory proteins and hormone receptors as well as assessing the effects of hormone replacement with testosterone on these parameters in the UChB rat prostate. The prostate structure, immunohistochemistry and receptor expression for AR (androgen receptor), ER± (estrogen receptor ±), ER² (estrogen receptor ²), inflammatory markers (Interleucin (IL)-6, IL-10, tumoral necrosis factor (TNF)-± and transforming growth factor (TGF)-²1), cell proliferation (Ki-67), apoptosis (TUNNEL), hormone measurement (total and free testosterone, dihydrotestosterone, estradiol and prolactin) will be evaluated. This study will provide new insights into the research area developed at the Department of Anatomy (IBB / UNESP) by the research team in Biology of Reproduction. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MENDES, LEONARDO O.; CASTILHO, ANTHONY C. S.; PINHO, CRISTIANE F.; GONCALVEZ, BIANCA F.; RAZZA, EDUARDO M.; CHUFFA, LUIZ GUSTAVO A.; ANSELMO-FRANCI, JANETE A.; SCARANO, WELLERSON R.; MARTINEZ, FRANCISCO E. Modulation of inflammatory and hormonal parameters in response to testosterone therapy: Effects on the ventral prostate of adult rats. Cell Biology International, v. 42, n. 9, p. 1200-1211, SEP 2018. Web of Science Citations: 0.
MENDES, LEONARDO O.; SCARANO, WELLERSON R.; ROCHEL-MAIA, SABRINA S.; FIORUCI-FONTANELI, BEATRIZ A.; CHUFFA, LUIZ G. A.; ANSELMO-FRANCI, JANETE A.; MARTINEZ, FRANCISCO E. Androgen therapy reverses injuries caused by ethanol consumption in the prostate: Testosterone as a possible target to ethanol-related disorders. Life Sciences, v. 120, p. 22-30, JAN 1 2015. Web of Science Citations: 4.

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