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Endometriosis: molecular bases of immune response

Grant number: 10/10338-0
Support type:Research Projects - Thematic Grants
Duration: February 01, 2012 - March 31, 2018
Field of knowledge:Biological Sciences - Immunology
Principal Investigator:Maurício Simões Abrão
Grantee:Maurício Simões Abrão
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:Jorge Elias Kalil Filho ; Luiz Vicente Rizzo ; Mari Cleide Sogayar
Assoc. researchers:Ana Claudia Oliveira Carreira Nishiyama ; Edmund Chada Baracat ; Jorge Elias Kalil Filho ; Karina Inacio Ladislau de Carvalho ; Mari Cleide Sogayar ; Verônica Porto Carreiro de Vasconcellos Coelho
Associated grant(s):13/03997-6 - Evaluation of the ezrin and the ezrin phosphorylated protein expression in lesions of pelvic endometriosis, AV.EXT
Associated scholarship(s):15/23686-0 - Endometriosis: molecular bases of the immune response, BP.IC
14/15753-7 - Endometriosis: molecular bases of immune response, BP.IC
12/17795-3 - Evaluation of Regulatory T cells, uterine NK and myeloid-derived suppressor cells in women with deep endometriosis, BP.MS

Abstract

Endometriosis is a benign gynecologic disorder characterized by the ectopic growth of misplaced endometrial cells. The retrograde menstruation theory, also known as Sampson's theory, proposes that viable endometrial tissue is refluxed through the fallopian tubes during menstruation and implants on peritoneal surface or pelvic organs. This peritoneal reflux could be a necessary but not sufficient condition for the development of endometriosis. Different studies have suggested that immunological mechanisms are involved in the pathophysiology of endometriosis. Clearly, the immune system is involved in endometriosis. It is not clear, however, what leads to the initiation, promotion, and progression of the disease. In some women who become endometriotic, the system of immunological clearance is inefficient or overwhelmed. This incapacity can be a result from either from the endometrium itself and/or from one or several anomalies in the factors present in the peritoneal environment such as: (1) cytokines; (2) natural killer cells; (3) macrophages; (4) dendritic cells; (5) T cell response. Facing these challenges, our goal in this study is to evaluate the cells and molecules present in the endometrial environment that could participate on the on/off circuit of the immunological clearance and that promotes the progression of endometriosis (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BELLELIS, PATRICK; BARBEIRO, DENISE FREDIANI; GUEUVOGHLANIAN-SILVA, BARBARA YASMIN; KALIL, JORGE; ABRAO, MAURICIO SIMOES; PODGAEC, SERGIO. Interleukin-15 and Interleukin-7 are the Major Cytokines to Maintain Endometriosis. GYNECOLOGIC AND OBSTETRIC INVESTIGATION, v. 84, n. 5, p. 435-444, SEP 2019. Web of Science Citations: 1.
RACHED, MARICI R.; COELHO, VERONICA; MARIN, MARIA LUCIA C.; PINCERATO, KSTJA; FUJITA, ANDRE; KALIL, JORGE E.; ABRAO, MAURICIO S. HLA-G is upregulated in advanced endometriosis. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, v. 235, p. 36-41, APR 2019. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.