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Development of multifunctional magnetic nanoparticles for cancer therapy


This project aims to develop magnetic nanoparticles (MNPs) with multifunctional properties for the potential treatment of cancer. For this, different MNPs will be synthesized by sputtering onto liquids and chemically functionalized with rhodamine B (fluorescent molecule), doxorubicin (DOX, antitumor drug) and folic acid (or monoclonal antibodies) to create target-specific nanocarriers with dual image property (magnetic and fluorescent), functional for both diagnosis and cancer therapy. The deeper understanding of the physical and chemical properties of these different materials and its application to cancer therapy by hyperthermia and delivery of antitumor drugs will feature the main objective of this project.To achieve this, the fundamental magnetic properties, shape, size, size distribution and chemical functionalizations of MNPs will be intensively investigated by different experimental techniques such as transmission electron microscopy (TEM), small angle X-ray scattering (SAXS), X-ray absorption spectroscopy (XAS), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), ultraviolet-visible spectroscopy (UV-Vis), infrared spectroscopy (IR), thermogravimetric analysis (TGA) and differential thermal analysis (DTA), among others. The hyperthermia experiments will be conducted in an adiabatic compartment by measuring the temperature of the system as a function of time in the presence of an alternating magnetic field. The release of drugs will be studied in simulated biological fluids and in normal and tumor commercial cells. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BARALDI DIAS, CARLOS SATO; GARCIA, FLAVIO; MAZALI, ITALO ODONE; CARDOSO, MATEUS BORBA; DE SOUZA E SILVA, JULIANA MARTINS. Direct route for preparing multi-oxide inorganic nanocomposites of nanoparticles-decorated nanotubes. Journal of Alloys and Compounds, v. 774, p. 1133-1139, FEB 5 2019. Web of Science Citations: 1.
DIAS, CARLOS S. B.; HANCHUK, TALITA D. M.; WENDER, HEBERTON; SHIGEYOSI, WILLIAN T.; KOBARG, JORG; ROSSI, ANDRE L.; TANAKA, MARCELO N.; CARDOSO, MATEUS B.; GARCIA, FLAVIO. Shape Tailored Magnetic Nanorings for Intracellular Hyperthermia Cancer Therapy. SCIENTIFIC REPORTS, v. 7, NOV 1 2017. Web of Science Citations: 13.
GONCALVES, RENATO V.; WOJCIESZAK, ROBERT; WENDER, HEBERTON; DIAS, CARLOS SATO B.; VONO, LUCAS L. R.; EBERHARDT, DARIO; TEIXEIRA, SERGIO R.; ROSSI, LIANE M. Easy Access to Metallic Copper Nanoparticles with High Activity and Stability for CO Oxidation. ACS APPLIED MATERIALS & INTERFACES, v. 7, n. 15, p. 7987-7994, APR 22 2015. Web of Science Citations: 26.
WENDER, HEBERTON; MIGOWSKI, PEDRO; FEIL, ADRIANO F.; TEIXEIRA, SERGIO R.; DUPONT, JAIRTON. Sputtering deposition of nanoparticles onto liquid substrates: Recent advances and future trends. Coordination Chemistry Reviews, v. 257, n. 17-18, SI, p. 2468-2483, SEP 2013. Web of Science Citations: 66.
WENDER, HEBERTON; GONCALVES, RENATO V.; DIAS, CARLOS SATO B.; ZAPATA, MAXIMILIANO J. M.; ZAGONEL, LUIZ F.; MENDONCA, EDIELMA C.; TEIXEIRA, SERGIO R.; GARCIA, FLAVIO. Photocatalytic hydrogen production of Co(OH)(2) nanoparticle-coated alpha-Fe2O3 nanorings. NANOSCALE, v. 5, n. 19, p. 9310-9316, 2013. Web of Science Citations: 38.

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