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Ovarian reserve, antibody anti-corpus luteum and lower genital tract infection in adult women with systemic lupus erythematosus, Behçet's syndrome and Takayasu's arteritis

Grant number: 11/12471-2
Support type:Regular Research Grants
Duration: March 01, 2012 - February 28, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Clovis Artur Almeida da Silva
Grantee:Clovis Artur Almeida da Silva
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers: Andrea Rocha de Saboia Mont Alverne ; Daniel Brito de Araujo ; Eloisa Silva Dutra de Oliveira Bonfá ; Lucas Yugo Shiguehara Yamakami ; Rosa Maria Rodrigues Pereira ; Sandra Gofinet Pasoto ; Vilma dos Santos Trindade Viana

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease of connective tissue, multisystemic. Behcet's syndrome (BS) and Takayasu's arteritis (TA) are inflammatory diseases of unknown etiology, classified as primary vasculitis, and may involve several organs. These three diseases affect women of reproductive age, which raises questions related to gonadal function in these patients. While much attention has been given to ovarian failure related to immunosuppressive therapy, little is known about ovarian reserve and the presence of autoantibodies anti-ovarian in these diseases. Objectives: to evaluate ovarian reserve, lower genital tract infection and the presence of antibody anti-corpus luteum in adult women with SLE, SB and TA, and its possible associations with demographic data, clinical manifestations, disease activity, cumulative damage and treatment. Methods: we will study 80 adult women in reproductive age with SLE, 40 with SB and 40 with AT, comparing them with a control group of 80 healthy women. We will assess demographic data, clinical manifestations of disease, laboratory findings and treatments. Hormonal evaluations and ovarian reserve will be determined by the measure of: follicle stimulating hormone, luteinizing hormone, estradiol, progesterone, prolactin, testosterone, inhibin A and B and anti-Mullerian hormone. We also will perform the dosage of antibody anti-corpus luteum, transvaginal ultrasound and HPV and Chlamydia search. (AU)

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Scientific publications (31)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOURENCO, BENITO; KOZU, KATIA T.; LEAL, GABRIELA N.; SILVA, MARCO F.; FERNANDES, ELISABETH G. C.; FRANCA, CAMILA M. P.; SOUZA, FERNANDO H. C.; SILVA, CLOVIS A. Contraception for adolescents with chronic rheumatic diseases. Revista Brasileira de Reumatologia, v. 57, n. 1, p. 73-81, JAN-FEB 2017. Web of Science Citations: 4.
BENITO LOURENÇO; KATIA T. KOZU; GABRIELA N. LEAL; MARCO F. SILVA; ELISABETH G.C. FERNANDES; CAMILA M.P. FRANÇA; FERNANDO H.C. SOUZA; CLOVIS A. SILVA. Contraception for adolescents with chronic rheumatic diseases. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 57, n. 1, p. 73-81, Fev. 2017.
MARQUES, VICTOR L. S.; GUARIENTO, ANDRESSA; SIMOES, MARLISE S. M.; BLAY, GABRIELA; LOTITO, ANA PAOLA N.; SILVA, CLOVIS A. Childhood-onset systemic polyarteritis nodosa and systemic lupus erythematosus: an overlap syndrome?. Revista Brasileira de Reumatologia, v. 56, n. 6, p. 551-553, NOV-DEC 2016. Web of Science Citations: 3.
MARLON VAN WEELDEN; LÍGIA B. QUEIROZ; DANIELA M.R. LOURENÇO; KATIA KOZU; BENITO LOURENÇO; CLOVIS A. SILVA. Alcohol, smoking and illicit drug use in pediatric systemic lupus erythematosus patients. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 56, n. 3, p. 228-234, Jun. 2016. Web of Science Citations: 5.
VIOLA, GABRIELA R.; GIACOMIN, MARIA FERNANDA A.; FRANCA, CAMILA M. P.; SALLUM, ADRIANA M. E.; JACOB, CRISTINA M. A.; SILVA, CLOVIS A. Chronic polyarthritis as isolated manifestation of toxocariasis. Revista Brasileira de Reumatologia, v. 56, n. 2, p. 185-187, MAR-APR 2016. Web of Science Citations: 1.
GABRIELA BLAY; MARIANA P.L. FERRIANI; IZABEL M. BUSCATTI; CAMILA M.P. FRANÇA; LUCIA M.A. CAMPOS; CLOVIS A. SILVA. Piomiosite no lúpus eritematoso sistêmico juvenil. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 56, n. 1, p. -, Fev. 2016.
GABRIELA R. VIOLA; MARIA FERNANDA A. GIACOMIN; CAMILA M.P. FRANÇA; ADRIANA M.E. SALLUM; CRISTINA M.A. JACOB; CLOVIS A. SILVA. Chronic polyarthritis as isolated manifestation of toxocariasis. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 56, n. 2, p. -, Abr. 2016.
MARLON VAN WEELDEN; BENITO LOURENÇO; GABRIELA R. VIOLA; NADIA E. AIKAWA; LÍGIA B. QUEIROZ; CLOVIS A. SILVA. Substance use and sexual function in juvenile idiopathic arthritis. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 56, n. 4, p. 323-329, Ago. 2016.
PRISCILA ARAÚJO; MÁRCIO GUILHERME NUNES CARVALHO; MARLON VAN WEELDEN; BENITO LOURENÇO; LÍGIA BRUNI QUEIROZ; CLOVIS ARTUR SILVA. Substance misuse and sexual function in adolescents with chronic diseases. Revista Paulista de Pediatria, v. 34, n. 3, p. 323-329, Set. 2016.
VICTOR L.S. MARQUES; ANDRESSA GUARIENTO; MARLISE S.M. SIMÕES; GABRIELA BLAY; ANA PAOLA N. LOTITO; CLOVIS A. SILVA. Childhood-onset systemic polyarteritis nodosa and systemic lupus erythematosus: an overlap syndrome?. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 56, n. 6, p. -, Dez. 2016.
CARLOS DE SOUZA, FERNANDO HENRIQUE; DA SILVA, CLOVIS ARTUR; SHIGUEHARA YAMAKAMI, LUCAS YUGO; TRINDADE VIANA, VILMA DOS SANTOS; BONFA, ELOISA; SHINJO, SAMUEL KATSUYUKI. Reduced ovarian reserve in patients with adult polymyositis. CLINICAL RHEUMATOLOGY, v. 34, n. 10, p. 1795-1799, OCT 2015. Web of Science Citations: 7.
GUARIENTO, ANDRESSA; SILVA, MARCO FELIPE C.; TASSETANO, PRISCILLA S. F.; ROCHA, SILVIA MARIA S.; CAMPOS, LUCIA M. A.; VALENTE, MARCELO; SILVA, CLOVIS A. Liver and spleen biometrics in childhood-onset systemic lupus erythematosus patients. Revista Brasileira de Reumatologia, v. 55, n. 4, p. 346-351, JUL-AUG 2015. Web of Science Citations: 3.
LEAL, G. N.; SILVA, K. F.; FRANCA, C. M. P.; LIANZA, A. C.; ANDRADE, J. L.; CAMPOS, L. M. A.; BONFA, E.; SILVA, C. A. Subclinical right ventricle systolic dysfunction in childhood-onset systemic lupus erythematosus: insights from two-dimensional speckle-tracking echocardiography. Lupus, v. 24, n. 6, p. 613-620, MAY 2015. Web of Science Citations: 16.
WAISBERG, MARIANA G.; RIBEIRO, ANA C. M.; CANDIDO, WELLINGTON M.; MEDEIROS, POLIANA B.; MATSUZAKI, CEZAR N.; BELDI, MARIANA C.; TACLA, MARICY; CAIAFFA-FILHO, HELIO H.; BONFA, ELOISA; SILVA, CLOVIS A. Human papillomavirus and chlamydia trachomatis infections in rheumatoid arthritis under anti-TNF therapy: an observational study. RHEUMATOLOGY INTERNATIONAL, v. 35, n. 3, p. 459-463, MAR 2015. Web of Science Citations: 5.
DE SOUZA, F. H. C.; SHINJO, S. K.; YAMAKAMI, L. Y. S.; VIANA, V. S. T.; BARACAT, E. C.; BONFA, E.; SILVA, C. A. Reduction of ovarian reserve in adult patients with dermatomyositis. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v. 33, n. 1, p. 44-49, JAN-FEB 2015. Web of Science Citations: 8.
ANDRESSA GUARIENTO; MARCO FELIPE C. SILVA; PRISCILLA S.F. TASSETANO; SÍLVIA MARIA S. ROCHA; LÚCIA M.A. CAMPOS; MARCELO VALENTE; CLOVIS A. SILVA. Biometria do fígado e do baço em pacientes com lúpus eritematoso sistêmico de início pediátrico. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 55, n. 4, p. -, Ago. 2015.
LOURENCO, D. M. R.; GOMES, R. CUNHA; AIKAWA, N. E.; CAMPOS, L. M. A.; ROMITI, R.; SILVA, C. A. Childhood-onset bullous systemic lupus erythematosus. Lupus, v. 23, n. 13, p. 1422-1425, NOV 2014. Web of Science Citations: 15.
MONT'ALVERNE, ANDREA ROCHA S.; PEREIRA, ROSA MARIA R.; YAMAKAMI, LUCAS YUGO S.; VIANA, VILMA SANTOS T.; BARACAT, EDMUND CHADA; BONFA, ELOISA; SILVA, CLOVIS ARTUR. Reduced Ovarian Reserve in Patients with Takayasu Arteritis. JOURNAL OF RHEUMATOLOGY, v. 41, n. 10, p. 2055-2059, OCT 2014. Web of Science Citations: 15.
YAMAKAMI, L. Y. S.; SERAFINI, P. C.; DE ARAUJO, D. B.; BONFA, E.; LEON, E. P.; BARACAT, E. C.; SILVA, C. A. Ovarian reserve in women with primary antiphospholipid syndrome. Lupus, v. 23, n. 9, p. 862-867, AUG 2014. Web of Science Citations: 16.
LUBE, GABRIELLA E.; AIKAWA, NADIA E.; TACLA, MARICY; LEAL, MARTA M.; LOURENCO, BENITO; SILVA, LUIZ E. V.; QUEIROZ, LIGIA B.; BARACAT, EDMUND C.; SILVA, CLOVIS A. Condyloma acuminatum in childhood-systemic lupus erythematosus patients. ACTA REUMATOLOGICA PORTUGUESA, v. 39, n. 2, p. 182-187, APR-JUN 2014. Web of Science Citations: 7.
SILVA, C. A.; COCUZZA, M.; CARVALHO, J. F.; BONFA, E. Diagnosis and classification of autoimmune orchitis. AUTOIMMUNITY REVIEWS, v. 13, n. 4-5, SI, p. 431-434, APR-MAY 2014. Web of Science Citations: 19.
SILVA, C. A.; YAMAKAMI, L. Y. S.; AIKAWA, N. E.; ARAUJO, D. B.; CARVALHO, J. F.; BONFA, E. Autoimmune primary ovarian insufficiency. AUTOIMMUNITY REVIEWS, v. 13, n. 4-5, SI, p. 427-430, APR-MAY 2014. Web of Science Citations: 51.
SOFIA S. MARTINS; IZABEL M. BUSCATTI; PRICILLA S. FREIRE; ERICA G. CAVALCANTE; ADRIANA M. SALLUM; LUCIA M.A. CAMPOS; CLOVIS A. SILVA. Doença de Kikuchi-Fujimoto antes do diagnóstico de lúpus eritematoso sistêmico juvenil. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 54, n. 5, p. -, Out. 2014.
DANIELA MR LOURENÇO; IZABEL M BUSCATTI; BENITO LOURENÇO; FERNANDA C MONTI; JOSÉ ALBINO PAZ; CLOVIS A SILVA. Neurite óptica em paciente com artrite idiopática juvenil. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 54, n. 6, p. -, Dez. 2014.
DE ARAUJO, D. B.; YAMAKAMI, L. Y. S.; AIKAWA, N. E.; BONFA, E.; VIANA, V. S. T.; PASOTO, S. G.; PEREIRA, R. M. R.; SERAFIN, P. C.; BORBA, E. F.; SILVA, C. A. Ovarian reserve in adult patients with childhood-onset lupus: a possible deleterious effect of methotrexate?. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, v. 43, n. 6, p. 503-511, 2014. Web of Science Citations: 11.
MARQUES, V. L. S.; GOMES, R. C.; VIOLA, G. R.; MAIA, M. M.; DURIGON, G. S.; AIKAWA, N. E.; SILVA, C. ARTUR. Pulmonary cryptococcosis in childhood systemic lupus erythematosus and Sjogren syndrome overlap: a rare opportunistic infection. Lupus, v. 22, n. 13, p. 1409-1412, NOV 2013. Web of Science Citations: 4.
SILVA, CLOVIS A.; AIKAWA, NADIA E.; BONFA, ELOISA. Vaccinations in juvenile chronic inflammatory diseases: an update. Nature Reviews Rheumatology, v. 9, n. 9, p. 532-543, SEP 2013. Web of Science Citations: 19.
BUSCATTI, IZABEL M.; GIACOMIN, MARIA FERNANDA A.; SILVA, MARCO FELIPE C.; CAMPOS, LUCIA M. A.; SALLUM, ADRIANA M. E.; SILVA, CLOVIS A. Laryngotracheal stenosis requiring emergency tracheostomy as the first manifestation of childhood-relapsing polychondritis. ACTA REUMATOLOGICA PORTUGUESA, v. 38, n. 3, p. 208-211, JUL-SEP 2013. Web of Science Citations: 1.
MOORTHY, L. N.; SAAD-MAGALHAES, C.; OLIVEIRA SATO, J.; LEN, C. A.; BRANDAO VASCO, M.; APPENZELLER, S.; MARINI, R.; FEITOSA DE OLIVEIRA, S. K.; RODRIGUES, M.; SZTAJNBOK, F.; GASPARELLO DE ALMEIDA, R.; ALMEIDA DE JESUS, A.; CAMPOS, L. M.; SILVA, C. A.; PETERSON, M. G. E.; HASSETT, A. L.; WEISS, E.; VERMA, S.; DAHODWALA, M. Q.; LEHMAN, T. J. A. Validation of the Portuguese Simple Measure of Impact of Lupus Erythematosus in Youngsters (SMILEY) in Brazil. Lupus, v. 22, n. 2, p. 190-197, FEB 2013. Web of Science Citations: 3.
SILVA, CLOVIS A.; AVCIN, TADEJ; BRUNNER, HERMINE I. Taxonomy for systemic lupus erythematosus with onset before adulthood. ARTHRITIS CARE & RESEARCH, v. 64, n. 12, p. 1787-1793, DEC 2012. Web of Science Citations: 71.
FRANCA, CAMILA M. P.; CAVALCANTE, ERICA G.; RIBEIRO, ALINE S. M.; OLIVEIRA, GUILHERME T.; LITVINOV, NADIA; SILVA, CLOVIS A. Disseminated histoplasmosis in a juvenile lupus erythematosus patient. ACTA REUMATOLOGICA PORTUGUESA, v. 37, n. 3, p. 276-279, JUL-SEP 2012. Web of Science Citations: 7.

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