Advanced search
Start date
Betweenand

Ovarian reserve, antibody anti-corpus luteum and lower genital tract infection in adult women with systemic lupus erythematosus, Behçet's syndrome and Takayasu's arteritis

Grant number: 11/12471-2
Support Opportunities:Regular Research Grants
Duration: March 01, 2012 - February 28, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Clovis Artur Almeida da Silva
Grantee:Clovis Artur Almeida da Silva
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers: Andrea Rocha de Saboia Mont Alverne ; Daniel Brito de Araujo ; Eloisa Silva Dutra de Oliveira Bonfá ; Lucas Yugo Shiguehara Yamakami ; Rosa Maria Rodrigues Pereira ; Sandra Gofinet Pasoto ; Vilma dos Santos Trindade Viana

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease of connective tissue, multisystemic. Behcet's syndrome (BS) and Takayasu's arteritis (TA) are inflammatory diseases of unknown etiology, classified as primary vasculitis, and may involve several organs. These three diseases affect women of reproductive age, which raises questions related to gonadal function in these patients. While much attention has been given to ovarian failure related to immunosuppressive therapy, little is known about ovarian reserve and the presence of autoantibodies anti-ovarian in these diseases. Objectives: to evaluate ovarian reserve, lower genital tract infection and the presence of antibody anti-corpus luteum in adult women with SLE, SB and TA, and its possible associations with demographic data, clinical manifestations, disease activity, cumulative damage and treatment. Methods: we will study 80 adult women in reproductive age with SLE, 40 with SB and 40 with AT, comparing them with a control group of 80 healthy women. We will assess demographic data, clinical manifestations of disease, laboratory findings and treatments. Hormonal evaluations and ovarian reserve will be determined by the measure of: follicle stimulating hormone, luteinizing hormone, estradiol, progesterone, prolactin, testosterone, inhibin A and B and anti-Mullerian hormone. We also will perform the dosage of antibody anti-corpus luteum, transvaginal ultrasound and HPV and Chlamydia search. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (31)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, CLOVIS A.; AVCIN, TADEJ; BRUNNER, HERMINE I.. Taxonomy for systemic lupus erythematosus with onset before adulthood. ARTHRITIS CARE & RESEARCH, v. 64, n. 12, p. 1787-1793, . (11/12471-2)
MOORTHY, L. N.; SAAD-MAGALHAES, C.; OLIVEIRA SATO, J.; LEN, C. A.; BRANDAO VASCO, M.; APPENZELLER, S.; MARINI, R.; FEITOSA DE OLIVEIRA, S. K.; RODRIGUES, M.; SZTAJNBOK, F.; et al. Validation of the Portuguese Simple Measure of Impact of Lupus Erythematosus in Youngsters (SMILEY) in Brazil. Lupus, v. 22, n. 2, p. 190-197, . (08/58238-4, 11/12471-2, 08/02917-0)
SILVA, CLOVIS A.; AIKAWA, NADIA E.; BONFA, ELOISA. Vaccinations in juvenile chronic inflammatory diseases: an update. Nature Reviews Rheumatology, v. 9, n. 9, p. 532-543, . (08/58238-4, 11/12471-2, 10/10749-0)
MARQUES, VICTOR L. S.; GUARIENTO, ANDRESSA; SIMOES, MARLISE S. M.; BLAY, GABRIELA; LOTITO, ANA PAOLA N.; SILVA, CLOVIS A.. Childhood-onset systemic polyarteritis nodosa and systemic lupus erythematosus: an overlap syndrome?. Revista Brasileira de Reumatologia, v. 56, n. 6, p. 551-553, . (08/58238-4, 11/12471-2)
VIOLA, GABRIELA R.; GIACOMIN, MARIA FERNANDA A.; FRANCA, CAMILA M. P.; SALLUM, ADRIANA M. E.; JACOB, CRISTINA M. A.; SILVA, CLOVIS A.. Chronic polyarthritis as isolated manifestation of toxocariasis. Revista Brasileira de Reumatologia, v. 56, n. 2, p. 185-187, . (08/58238-4, 11/12471-2)
LEAL, G. N.; SILVA, K. F.; FRANCA, C. M. P.; LIANZA, A. C.; ANDRADE, J. L.; CAMPOS, L. M. A.; BONFA, E.; SILVA, C. A.. Subclinical right ventricle systolic dysfunction in childhood-onset systemic lupus erythematosus: insights from two-dimensional speckle-tracking echocardiography. Lupus, v. 24, n. 6, p. 613-620, . (11/12471-2)
LUBE, GABRIELLA E.; AIKAWA, NADIA E.; TACLA, MARICY; LEAL, MARTA M.; LOURENCO, BENITO; SILVA, LUIZ E. V.; QUEIROZ, LIGIA B.; BARACAT, EDMUND C.; SILVA, CLOVIS A.. Condyloma acuminatum in childhood-systemic lupus erythematosus patients. ACTA REUMATOLOGICA PORTUGUESA, v. 39, n. 2, p. 182-187, . (11/12471-2)
LOURENCO, D. M. R.; GOMES, R. CUNHA; AIKAWA, N. E.; CAMPOS, L. M. A.; ROMITI, R.; SILVA, C. A.. Childhood-onset bullous systemic lupus erythematosus. Lupus, v. 23, n. 13, p. 1422-1425, . (08/58238-4, 11/12471-2)
SILVA, C. A.; COCUZZA, M.; CARVALHO, J. F.; BONFA, E.. Diagnosis and classification of autoimmune orchitis. AUTOIMMUNITY REVIEWS, v. 13, n. 4-5, SI, p. 431-434, . (08/58238-4, 11/12471-2)
DE ARAUJO, D. B.; YAMAKAMI, L. Y. S.; AIKAWA, N. E.; BONFA, E.; VIANA, V. S. T.; PASOTO, S. G.; PEREIRA, R. M. R.; SERAFIN, P. C.; BORBA, E. F.; SILVA, C. A.. Ovarian reserve in adult patients with childhood-onset lupus: a possible deleterious effect of methotrexate?. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, v. 43, n. 6, p. 503-511, . (11/12471-2)
BENITO LOURENÇO; KATIA T. KOZU; GABRIELA N. LEAL; MARCO F. SILVA; ELISABETH G.C. FERNANDES; CAMILA M.P. FRANÇA; FERNANDO H.C. SOUZA; CLOVIS A. SILVA. Contracepção para adolescentes com doenças reumáticas crônicas. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 57, n. 1, p. 73-81, . (11/12471-2, 14/14806-0)
YAMAKAMI, L. Y. S.; SERAFINI, P. C.; DE ARAUJO, D. B.; BONFA, E.; LEON, E. P.; BARACAT, E. C.; SILVA, C. A.. Ovarian reserve in women with primary antiphospholipid syndrome. Lupus, v. 23, n. 9, p. 862-867, . (11/12471-2)
DE SOUZA, F. H. C.; SHINJO, S. K.; YAMAKAMI, L. Y. S.; VIANA, V. S. T.; BARACAT, E. C.; BONFA, E.; SILVA, C. A.. Reduction of ovarian reserve in adult patients with dermatomyositis. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v. 33, n. 1, p. 44-49, . (11/12471-2, 11/15609-5)
FRANCA, CAMILA M. P.; CAVALCANTE, ERICA G.; RIBEIRO, ALINE S. M.; OLIVEIRA, GUILHERME T.; LITVINOV, NADIA; SILVA, CLOVIS A.. Disseminated histoplasmosis in a juvenile lupus erythematosus patient. ACTA REUMATOLOGICA PORTUGUESA, v. 37, n. 3, p. 276-279, . (11/12471-2)
SOFIA S. MARTINS; IZABEL M. BUSCATTI; PRICILLA S. FREIRE; ERICA G. CAVALCANTE; ADRIANA M. SALLUM; LUCIA M.A. CAMPOS; CLOVIS A. SILVA. Doença de Kikuchi-Fujimoto antes do diagnóstico de lúpus eritematoso sistêmico juvenil. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 54, n. 5, p. 400-403, . (11/12471-2, 08/58238-4)
DANIELA MR LOURENÇO; IZABEL M BUSCATTI; BENITO LOURENÇO; FERNANDA C MONTI; JOSÉ ALBINO PAZ; CLOVIS A SILVA. Neurite óptica em paciente com artrite idiopática juvenil. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 54, n. 6, p. 486-489, . (11/12471-2, 08/58238-4)
MARQUES, V. L. S.; GOMES, R. C.; VIOLA, G. R.; MAIA, M. M.; DURIGON, G. S.; AIKAWA, N. E.; SILVA, C. ARTUR. Pulmonary cryptococcosis in childhood systemic lupus erythematosus and Sjogren syndrome overlap: a rare opportunistic infection. Lupus, v. 22, n. 13, p. 1409-1412, . (08/58238-4, 11/12471-2)
SILVA, C. A.; YAMAKAMI, L. Y. S.; AIKAWA, N. E.; ARAUJO, D. B.; CARVALHO, J. F.; BONFA, E.. Autoimmune primary ovarian insufficiency. AUTOIMMUNITY REVIEWS, v. 13, n. 4-5, p. 4-pg., . (11/12471-2, 08/58238-4)
SILVA, C. A.; COCUZZA, M.; CARVALHO, J. F.; BONFA, E.. Diagnosis and classification of autoimmune orchitis. AUTOIMMUNITY REVIEWS, v. 13, n. 4-5, p. 4-pg., . (11/12471-2, 08/58238-4)
GUARIENTO, ANDRESSA; SILVA, MARCO FELIPE C.; TASSETANO, PRISCILLA S. F.; ROCHA, SILVIA MARIA S.; CAMPOS, LUCIA M. A.; VALENTE, MARCELO; SILVA, CLOVIS A.. Liver and spleen biometrics in childhood-onset systemic lupus erythematosus patients. Revista Brasileira de Reumatologia, v. 55, n. 4, p. 346-351, . (11/12471-2)
CARLOS DE SOUZA, FERNANDO HENRIQUE; DA SILVA, CLOVIS ARTUR; SHIGUEHARA YAMAKAMI, LUCAS YUGO; TRINDADE VIANA, VILMA DOS SANTOS; BONFA, ELOISA; SHINJO, SAMUEL KATSUYUKI. Reduced ovarian reserve in patients with adult polymyositis. CLINICAL RHEUMATOLOGY, v. 34, n. 10, p. 1795-1799, . (11/12471-2, 11/15609-5)
MARLON VAN WEELDEN; LÍGIA B. QUEIROZ; DANIELA M.R. LOURENÇO; KATIA KOZU; BENITO LOURENÇO; CLOVIS A. SILVA. Uso de álcool, tabaco e drogas ilícitas por pacientes com lúpus eritematoso sistêmico pediátrico. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 56, n. 3, p. 228-234, . (11/12471-2)
GABRIELA BLAY; MARIANA P.L. FERRIANI; IZABEL M. BUSCATTI; CAMILA M.P. FRANÇA; LUCIA M.A. CAMPOS; CLOVIS A. SILVA. Piomiosite no lúpus eritematoso sistêmico juvenil. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 56, n. 1, p. 79-81, . (11/12471-2, 08/58238-4)
ANDRESSA GUARIENTO; MARCO FELIPE C. SILVA; PRISCILLA S.F. TASSETANO; SÍLVIA MARIA S. ROCHA; LÚCIA M.A. CAMPOS; MARCELO VALENTE; CLOVIS A. SILVA. Biometria do fígado e do baço em pacientes com lúpus eritematoso sistêmico de início pediátrico. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 55, n. 4, p. 346-351, . (11/12471-2)
LOURENCO, BENITO; KOZU, KATIA T.; LEAL, GABRIELA N.; SILVA, MARCO F.; FERNANDES, ELISABETH G. C.; FRANCA, CAMILA M. P.; SOUZA, FERNANDO H. C.; SILVA, CLOVIS A.. Contraception for adolescents with chronic rheumatic diseases. Revista Brasileira de Reumatologia, v. 57, n. 1, p. 73-81, . (14/14806-0, 11/12471-2)
PRISCILA ARAÚJO; MÁRCIO GUILHERME NUNES CARVALHO; MARLON VAN WEELDEN; BENITO LOURENÇO; LÍGIA BRUNI QUEIROZ; CLOVIS ARTUR SILVA. Uso indevido de drogas e função sexual em adolescentes com doenças crônicas. Revista Paulista de Pediatria, v. 34, n. 3, p. 323-329, . (11/12471-2, 14/14806-0)
MARLON VAN WEELDEN; BENITO LOURENÇO; GABRIELA R. VIOLA; NADIA E. AIKAWA; LÍGIA B. QUEIROZ; CLOVIS A. SILVA. Uso de substâncias e função sexual na artrite idiopática juvenil. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 56, n. 4, p. 323-329, . (11/12471-2)
WAISBERG, MARIANA G.; RIBEIRO, ANA C. M.; CANDIDO, WELLINGTON M.; MEDEIROS, POLIANA B.; MATSUZAKI, CEZAR N.; BELDI, MARIANA C.; TACLA, MARICY; CAIAFFA-FILHO, HELIO H.; BONFA, ELOISA; SILVA, CLOVIS A.. Human papillomavirus and chlamydia trachomatis infections in rheumatoid arthritis under anti-TNF therapy: an observational study. RHEUMATOLOGY INTERNATIONAL, v. 35, n. 3, p. 459-463, . (11/12471-2)
SILVA, C. A.; YAMAKAMI, L. Y. S.; AIKAWA, N. E.; ARAUJO, D. B.; CARVALHO, J. F.; BONFA, E.. Autoimmune primary ovarian insufficiency. AUTOIMMUNITY REVIEWS, v. 13, n. 4-5, SI, p. 427-430, . (08/58238-4, 11/12471-2)
BUSCATTI, IZABEL M.; GIACOMIN, MARIA FERNANDA A.; SILVA, MARCO FELIPE C.; CAMPOS, LUCIA M. A.; SALLUM, ADRIANA M. E.; SILVA, CLOVIS A.. Laryngotracheal stenosis requiring emergency tracheostomy as the first manifestation of childhood-relapsing polychondritis. ACTA REUMATOLOGICA PORTUGUESA, v. 38, n. 3, p. 208-211, . (08/58238-4, 11/12471-2)
MONT'ALVERNE, ANDREA ROCHA S.; PEREIRA, ROSA MARIA R.; YAMAKAMI, LUCAS YUGO S.; VIANA, VILMA SANTOS T.; BARACAT, EDMUND CHADA; BONFA, ELOISA; SILVA, CLOVIS ARTUR. Reduced Ovarian Reserve in Patients with Takayasu Arteritis. JOURNAL OF RHEUMATOLOGY, v. 41, n. 10, p. 2055-2059, . (11/12471-2)

Please report errors in scientific publications list by writing to: gei-bv@fapesp.br.