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Sustainable use of biodiversity in Atlantic Forest remnants in São Paulo: evaluation, isolation and molecular characterization of bioactive secondary metabolites in plant species

Grant number: 11/51739-0
Support type:BIOTA-FAPESP Program - Regular Research Grants
Duration: March 01, 2012 - February 28, 2014
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:João Henrique Ghilardi Lago
Grantee:João Henrique Ghilardi Lago
Home Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil


In the present project will be selected plant species that occur in the remaining areas of Atlantic Forest of São Paulo, considered a hotspot because of the wide diversity of vegetation and the need for conservation and sustainable use. This project has as main objective the pharmacological studies, isolation and structural determination of active compounds, and the establishment of relationships structure / biological activity with the compounds obtained from plant matrices. Therefore, species belonging to different plant families will be collected and their extracts are prepared and are then subjected to a series of bioassays in order to select those with potential biological activity, particularly antimicrobial (antibacterial and antifungal), antiprotozoal (antimalarial, anti-leishmania and trypanocidal), antitumoral and at glycemic methabolism. Then the promising extracts will be fractionated, the active metabolites purified by chromatographic techniques and their structures determined by spectroscopic and spectrometric techniques. After isolation of active substances, they may be subjected to tests of SAR through different molecular changes in order to find pharmacophore groups. Moreover, they are taken their volatile oils, which are chemically analyzed and subjected to the evaluation of biological potential. Thus, this project aims to add new compounds and / or extracts with proven pharmacological activity restricted to the herbal therapeutic, providing tools for sustainable development in areas at risk of extinction. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Biocompound from Atlantic Rainforest combats leishmaniasis and Chagas disease 
Testing of a natural compound against leishmaniasis and Chagas disease 
Plant from Brazil contains a compound with an anti-inflammatory action 
Collaborative research augments therapy for visceral leishmaniasis 
Articles published in other media outlets (1 total):
Composto natural é testado contra leishmaniose e doença de Chagas 

Scientific publications (15)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GAMES, ELLEN; GUERREIRO, MARINA; SANTANA, FERNANDA R.; PINHEIRO, NATHALIA M.; DE OLIVEIRA, EMERSON A.; LOPES, FERNANDA D. T. Q. S.; OLIVO, CLARICE R.; TIBERIO, IOLANDA F. L. C.; MARTINS, MILTON A.; LAGO, JOAO HENRIQUE G.; PRADO, CARLA M. Structurally Related Monoterpenes p-Cymene, Carvacrol and Thymol Isolated from Essential Oil from Leaves of Lippia sidoides Cham. (Verbenaceae) Protect Mice against Elastase-Induced Emphysema. Molecules, v. 21, n. 10 OCT 2016. Web of Science Citations: 8.
GIROLA, NATALIA; FIGUEIREDO, CARLOS R.; FARIAS, CAMYLA F.; AZEVEDO, RICARDO A.; FERREIRA, ADILSON K.; TEIXEIRA, SARAH F.; CAPELLO, TABATA M.; MARTINS, EUDER G. A.; MATSUO, ALISSON L.; TRAVASSOS, LUIZ R.; LAGO, JOAO H. G. Camphene isolated from essential oil of Piper cernuum (Piperaceae) induces intrinsic apoptosis in melanoma cells and displays antitumor activity in vivo. Biochemical and Biophysical Research Communications, v. 467, n. 4, p. 928-934, NOV 27 2015. Web of Science Citations: 17.
BOU, DIEGO D.; DOS SANTOS, AUGUSTO L.; FIGUEIREDO, CARLOS R.; FARIAS, CAMYLA F.; MATSUO, ALISSON L.; KITAMURA, RODRIGO O. S.; GIMENES, LEILA; LAGO, JOAO H. G.; SARTORELLI, PATRICIA. Dinor Casearin X, a New Cytotoxic Clerodane Diterpene from Casearia sylvestris. Journal of the Brazilian Chemical Society, v. 26, n. 8, p. 1725-1729, AUG 2015. Web of Science Citations: 3.
SANTOS, LUCIANA DE A.; CAVALHEIRO, ALBERTO J.; TEMPONE, ANDRE G.; CORREA, DANIELA S.; ALEXANDRE, TATIANA R.; QUINTILIANO, NATALIA F.; RODRIGUES-OLIVEIRA, ANDRE F.; OLIVEIRA-SILVA, DIOGO; MARTINS, ROBERTO CARLOS C.; LAGO, JOAO HENRIQUE G. Antitrypanosomal Acetylene Fatty Acid Derivatives from the Seeds of Porcelia macrocarpa (Annonaceae). Molecules, v. 20, n. 5, p. 8168-8180, MAY 2015. Web of Science Citations: 4.
DIEGO D. BOU; AUGUSTO L. DOS SANTOS; CARLOS R. FIGUEIREDO; CAMYLA F. FARIAS; ALISSON L. MATSUO; RODRIGO O. S. KITAMURA; LEILA GIMENES; JOÃO H. G. LAGO; PATRICIA SARTORELLI. Dinor Casearin X, a New Cytotoxic Clerodane Diterpene from Casearia sylvestris. Journal of the Brazilian Chemical Society, v. 26, n. 8, p. -, Ago. 2015.
BARROSA, KAIDU H.; PINTO, ERIKA G.; TEMPONE, ANDRE G.; MARTINS, EUDER GLENDES A.; LAGO, JOAO HENRIQUE G. Alchornedine, a New Anti-Trypanosomal Guanidine Alkaloid from Alchornea glandulosa. Planta Medica, v. 80, n. 15, p. 1310-1314, OCT 2014. Web of Science Citations: 8.
DAL PICOLO, CAMILLA R.; BEZERRA, MARIANA P.; GOMES, KAIO S.; PASSERO, LUIZ FELIPE D.; LAURENTI, MARCIA D.; MARTINS, EUDER GLENDES A.; SARTORELLI, PATRICIA; LAGO, JOAO HENRIQUE G. Antileishmanial activity evaluation of adunchalcone, a new prenylated dihydrochalcone from Piper aduncum L.. Fitoterapia, v. 97, p. 28-33, SEP 2014. Web of Science Citations: 17.
GRECCO, SIMONE DOS S.; DORIGUETO, ANTONIO C.; LANDRE, IARA M.; SOARES, MARISI G.; MARTHO, KEVIN; LIMA, RICARDO; PASCON, RENATA C.; VALLIM, MARCELO A.; CAPELLO, TABATA M.; ROMOFF, PAULETE; SARTORELLI, PATRICIA; LAGO, JOAO HENRIQUE G. Structural Crystalline Characterization of Sakuranetin - An Antimicrobial Flavanone from Twigs of Baccharis retusa (Asteraceae). Molecules, v. 19, n. 6, p. 7528-7542, JUN 2014. Web of Science Citations: 4.
MORAIS, THIAGO R.; DA COSTA-SILVA, THAIS A.; TEMPONE, ANDRE G.; BORBOREMA, SAMANTA ETEL T.; SCOTTI, MARCUS T.; DE SOUSA, RAQUEL MARIA F.; ARAUJO, ANA CAROLINA C.; DE OLIVEIRA, ALBERTO; DE MORAIS, SERGIO ANTONIO L.; SARTORELLI, PATRICIA; LAGO, JOAO HENRIQUE G. Antiparasitic Activity of Natural and Semi-Synthetic Tirucallane Triterpenoids from Schinus terebinthifolius (Anacardiaceae): Structure/Activity Relationships. Molecules, v. 19, n. 5, p. 5761-5776, MAY 2014. Web of Science Citations: 8.
BOU, DIEGO DINIS; TEMPORRE, ANDRE G.; PINTO, ERIKA G.; LAGOA, JOAO HENRIQUE G.; SARTORELLIA, PATRICIA. Antiparasitic activity and effect of casearins isolated from Casearia sylvestris on Leishmania and Trypanosoma cruzi plasma membrane. Phytomedicine, v. 21, n. 5, p. 676-681, APR 15 2014. Web of Science Citations: 19.
LAGO, JOAO HENRIQUE G.; TOLEDO-ARRUDA, ALESSANDRA C.; MERNAK, MARCIA; BARROSA, KAIDU H.; MARTINS, MILTON A.; TIBERIO, IOLANDA F. L. C.; PRADO, CARLA M. Structure-Activity Association of Flavonoids in Lung Diseases. Molecules, v. 19, n. 3, p. 3570-3595, MAR 2014. Web of Science Citations: 42.
GREECO, SIMONE DOS S.; FELIX, MARIA JULIA P.; LAGO, JOAO HENRIQUE G.; PINTO, ERIKA G.; TEMPONE, ANDRE G.; ROMOFF, PAULETE; FERREIRA, MARCELO JOSE P.; SARTORELLI, PATRICIA. Anti-trypanosomal Phenolic Derivatives from Baccharis uncinella. NATURAL PRODUCT COMMUNICATIONS, v. 9, n. 2, p. 171-173, FEB 2014. Web of Science Citations: 11.
REA, ALEXANDRE; TEMPONE, ANDRE G.; PINTO, ERIKA G.; MESQUITA, JULIANA T.; RODRIGUES, ELIANA; SILVA, LUCIANA GRUS M.; SARTORELLI, PATRICIA; LAGO, JOAO HENRIQUE G. Soulamarin Isolated from Calophyllum brasiliense (Clusiaceae) Induces Plasma Membrane Permeabilization of Trypanosoma cruzi and Mytochondrial Dysfunction. PLoS Neglected Tropical Diseases, v. 7, n. 12 DEC 2013. Web of Science Citations: 24.
DA SILVA, ERICA BIOLCATI P.; SOARES, MARISI G.; MARIANE, BRUNA; VALLIM, MARCELO A.; PASCON, RENATA C.; SARTORELLI, PATRICIA; LAGO, JOAO HENRIQUE G. The Seasonal Variation of the Chemical Composition of Essential Oils from Porcelia macrocarpa RE Fries (Annonaceae) and Their Antimicrobial Activity. Molecules, v. 18, n. 11, p. 13574-13587, NOV 2013. Web of Science Citations: 3.
BOU, DIEGO DINIS; LAGO, JOAO HENRIQUE G.; FIGUEIREDO, CARLOS R.; MATSUO, ALISSON L.; GUADAGNIN, RAFAEL C.; SOARES, MARISI G.; SARTORELLI, PATRICIA. Chemical Composition and Cytotoxicity Evaluation of Essential Oil from Leaves of Casearia Sylvestris, Its Main Compound alpha-Zingiberene and Derivatives. Molecules, v. 18, n. 8, p. 9477-9487, AUG 2013. Web of Science Citations: 28.

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