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Natural Killer cell-mediated targeting of human ovarian cancer and possibilities for immunotherapy

Abstract

We have shown recently the possibility of generating effector cell preparations enriched with CD56+ lymphocytes, NK and NKT-like, by ex vivo expansion of peripheral blood mononuclear cells (PBMC) from patients with ovarian cancer (FAPESP 2006/04900-2). The current project proposes to evaluate the receptor repertoire (inhibitory receptors: KIR2DL1, KIR2DL2/3 and KIR3DL1 and activating receptors: NKp30, NKp44, NKp46, NKG2D and DNAM-1) and functional integrity (CD107a molecule expression and cytotoxicity against primary neoplasm cells) of the NK and NKT-like lymphocytes from patients with ovarian neoplasm, before and after the ex vivo expansion of CD56+ cells. The experimental design will allow the evaluation of effector cell subtypes independently, and to take into account the clinical stage of the subjects. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, RODRIGO FERNANDES; CARDOZO, DANIELA MAIRA; LIBANIO RODRIGUES, GISELE OLINTO; DE SOUZA-ARAUJO, CAROLINE NATANIA; MIGITA, NATACHA AZUSSA; LUCCI DE ANGELO ANDRADE, LILIANA APARECIDA; DERCHAIN, SOPHIE; YUNES, JOSE ANDRES; GUIMARAES, FERNANDO. CAISMOV24, a new human low-grade serous ovarian carcinoma cell line. BMC CANCER, v. 17, NOV 13 2017. Web of Science Citations: 0.
DA SILVA, RODRIGO FERNANDES; PETTA, CARLOS ALBERTO; DERCHAIN, SOPHIE FRANCOISE; ALICI, EVREN; GUIMARAES, FERNANDO. Up-regulation of DNAM-1 and NKp30, associated with improvement of NK cells activation after long-term culture of mononuclear cells from patients with ovarian neoplasia. HUMAN IMMUNOLOGY, v. 75, n. 8, p. 777-784, AUG 2014. Web of Science Citations: 6.

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