Advanced search
Start date

Participation of mast cells and histamine on inflammatory events induced by Potamotrygon motoro stingray venom in murine model

Grant number: 12/00166-3
Support type:Regular Research Grants
Duration: April 01, 2012 - June 30, 2014
Field of knowledge:Biological Sciences - Immunology
Principal Investigator:Katia Cristina Barbaro Nogueira
Grantee:Katia Cristina Barbaro Nogueira
Home Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Assoc. researchers:Eliana Faquim de Lima Mauro ; Marta Maria Antoniazzi


Stingrays are elasmobranchs found in both tropical and temperate seas and in freshwater rivers. They exhibit the habit of being buried in shallow graves in the sand or mud. In some families, there is one or more stings retrosserated bilaterally located in the tail, formed by a mineralized structure covered by layers of epidermal cells. Stingray accidents often occur when the animals are stepped, and as a defensive behavior, they whip the tail toward the stimulated site, inserting the sting in the victim's member. Besides mechanical trauma caused by the sting, the toxic components present in the tissue that covers it cause intense pain followed by erythema, edema and necrosis, that may even cripple the affected limb. There is no specific treatment to date for stingrays envenomation and therapy is based on the administration of anti-inflammatory, analgesics and antipyretics drugs, as well as local cleaning and removal of fragments of the sting. Once Potamotrygon motoro stingray venom causes an immediate and intense local inflammation, this project aim to determine in vivo the involvement of activated mast cells and histamine receptors of subtypes H1, H2 and H3/H4 in edema and cell influx induced by the venom. Additionally, it will be evaluate the action of P. motoro venom in in vitro mast cells cultures from rat and mouse. The results of this project can contribute to understanding the pathophysiology of stingray envenomation as well as helping in the search for symptomatic treatments for these accidents. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KIMURA, L. F.; SANTOS-NETO, M.; BARBARO, K. C.; PICOLO, G. Potamotrygon motoro stingray venom induces both neurogenic and inflammatory pain behavior in rodents. Toxicon, v. 150, p. 168-174, AUG 2018. Web of Science Citations: 0.
KIMURA, LOUISE F.; PREZOTTO-NETO, JOSE PEDRO; TAVORA, BIANCA C. L. F.; FAQUIM-MAURO, ELIANA L.; PEREIRA, NICOLE A.; ANTONIAZZI, MALTA M.; JARED, SIMONE G. S.; TEIXEIRA, CATARINA F. P.; SANTORO, MARCELO L.; BARBARO, KATIA C. Mast cells and histamine play an important role in edema and leukocyte recruitment induced by Potamotrygon motoro stingray venom in mice. Toxicon, v. 103, p. 65-73, SEP 1 2015. Web of Science Citations: 7.
KIMURA, LOUISE F.; PREZOTTO-NETO, JOSE P.; ANTONIAZZI, MARTA M.; JARED, SIMONE G. S.; SANTORO, MARCELO L.; BARBARO, KATIA C. Characterization of inflammatory response induced by Potamotrygon motoro stingray venom in mice. Experimental Biology and Medicine, v. 239, n. 5, p. 601-609, MAY 2014. Web of Science Citations: 8.

Please report errors in scientific publications list by writing to: