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Surveillance of bovine abortion: bovine leukemia virus as casual agent


The Laboratory of Anatomopathology of Instituto Biológico has done in the last two years, histopathological diagnosis in aborted bovine fetuses, finding in 73.5% (86/117) of the cases mononuclear and/or polymorphonuclear inflammatory infiltrate, showing the involvement of an infectious agent and proving the necessity of combination of sensitive and specific methods to conclude the causal agent. The casuistic of Instituto Biológico done in the last 20 years by it´s multidisciplinar team revealed that 70.0% of aborted fetuses submitted to virological and bacteriological analysis have inconclusive diagnosis, being Brucellosis the most prevalent disease. The Bovine Leukemia Virus (BLV) causes lymphocitosis and lymphossarcoma, and it´s prevalent in Brazilian herds, associated to the findings that the majority of aborted fetuses presents mononuclear inflammatory infiltrate, we performed a previous study and it was detected BLV proviral DNA by PCR in 18.2% (2/11) of fetuses (timus and spleen) negative for Brucellosis. These preliminary results enforce the research proposed, that aims to verify in aborted bovine fetuses negative to Brucellosis the occurrence of BLV by PCR and fetal serology, and correlating these findings with histopathology, fetal age and origin of the samples. The genomic sequencing of the BLV will be performed in order to verify the genetic polymorphism of the samples obtained. (AU)

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