Advanced search
Start date
Betweenand

Cervico-vaginal humoral response (IgA secretora) in women wich received the quadrivalent vaccine against HPV

Grant number: 11/19960-9
Support type:Regular Research Grants
Duration: May 01, 2012 - April 30, 2015
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal researcher:Paulo César Giraldo
Grantee:Paulo César Giraldo
Home Institution: Centro de Atenção Integral à Saúde da Mulher (CAISM). Hospital da Mulher Professor Doutor José Aristodemo Pinotti. Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Assoc. researchers: Ana Katherine da Silveira Gonçalves de Oliveira ; Joziani Beghini Junqueira de Carvalho Ferreira

Abstract

HPV vaccination has been found to be very effective against infection, however little is known concerning its therapeutic properties. Secretory IgA (sIgA) neutralizes viruses from inside the infected cells by means of transcytosis, which could explain possible therapeutic qualities. Objective: To quantify and compare the specific and total secretory IgA levels before and after vaccination. Subjects and Methods: This clinical study on immunogenicity will evaluate vaginal secretory IgA in 60 healthy women between the ages of 18 and 26, all without induced HPV lesions or history, as well as negative Pap smears. Samples will be collected from the uterine cervix for detection and genotyping of HPV 6, 11, 16 and 18 as well as quantification of total and specific sIgA. Collection will take place on day zero, as well as six months and twelve months after vaccination. Sample size was based on previous studies, wherein sIgA levels before and after vaccination were estimated. Considering a test with 80% power and 5% significance level, the required sample size was calculated at n = 46. The statistics suggest sample size be increased by 10% to 20% due to losses accrued during follow-up. Our hypothesis is that vaccinated women will present higher levels of sIgA specific to HPV 6,11,16 and 18. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BEGHINI, JOZIANI; GIRALDO, PAULO C.; ELEUTERIO, JR., JOSE; DO AMARAL, ROSE LUCE; POLPETA, NADIA C.; GONCALVES, ANA KATHERINE. Vaginal Inflammation: Association between Leukocyte Concentration and Levels of Immune Mediators. American Journal of Reproductive Immunology, v. 75, n. 2, p. 126-133, FEB 2016. Web of Science Citations: 1.
BEGHINI, J.; LINHARES, I. M.; GIRALDO, P. C.; LEDGER, W. J.; WITKIN, S. S. Differential expression of lactic acid isomers, extracellular matrix metalloproteinase inducer, and matrix metalloproteinase-8 in vaginal fluid from women with vaginal disorders. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, v. 122, n. 12, p. 1580-1585, NOV 2015. Web of Science Citations: 12.
NASIOUDIS, DIMITRIOS; BEGHINI, JOZIANI; BONGIOVANNI, ANN MARIE; GIRALDO, PAULO C.; LINHARES, IARA M.; WITKIN, STEVEN S. -Amylase in Vaginal Fluid: Association With Conditions Favorable to Dominance of Lactobacillus. REPRODUCTIVE SCIENCES, v. 22, n. 11, p. 1393-1398, NOV 2015. Web of Science Citations: 19.
BEGHINI, JOZIANI; GIRALDO, PAULO C.; LINHARES, IARA M.; LEDGER, WILLIAM J.; WITKIN, STEVEN S. Neutrophil Gelatinase-Associated Lipocalin Concentration in Vaginal Fluid: Relation to Bacterial Vaginosis and Vulvovaginal Candidiasis. REPRODUCTIVE SCIENCES, v. 22, n. 8, p. 964-968, AUG 2015. Web of Science Citations: 10.
GONCALVES, ANA KATHERINE; LIMA MACHADO, PAULA RENATA; DE SOUZA, LUANDA CANARIO; FERREIRA COSTA, ANA PAULA; GIMENES, FABRICIA; CONSOLARO, MARCIA LOPES; CRISPIM, JANAINA OLIVEIRA; ELEUTERIO, JR., JOSE; GIRALDO, PAULO CESAR. Detection of Immunoglobulin IgA and IgG Against Human Papilloma Virus. VIRAL IMMUNOLOGY, v. 27, n. 9, p. 471-477, NOV 1 2014. Web of Science Citations: 2.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.