Evaluation of melatonin antioxidant properties upon fresh and cryopreserved in vitro produced bovine embryos

• Grant number: 11/21529-4
• Support type: Regular Research Grants
• Duration: May 01, 2012 - April 30, 2014
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Reproduction
• Principal researcher: Mayra Elena Ortiz D' Avila Assumpcao
• Grantee: Mayra Elena Ortiz D' Avila Assumpcao
• Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Meat production is an economically important industry in Brazil. In vitro embryo production (IVP) is a tool for breeding schemes. Vitrification is the main technique for long period high quality embryo storage. However, the current development status of both technologies is far from ideal. Oxidative stress in pathological levels impairs mammal embryo development in vitro. After cryopreservation embryos are more susceptible to oxidative damage. Melatonin and its metabolites are potent antioxidant agents. When applied to in vitro embryo production systems protects oocytes and embryos. This project aims to evaluate melatonin's effect over embryo development cryotolerance and its postthaw in vitro development. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE ASSIS, PATRICIA MONKEN; CASTRO, LETICIA SIGNORI; PEREZ SIQUEIRA, ADRIANO FELIPE; DELGADO, JULIANA DE CARVALHO; DOS SANTOS HAMILTON, THAIS ROSE; GOISSIS, MARCELO DEMARCHI; MENDES, CAMILLA MOTA; NICHI, MARCILIO; VISINTIN, JOSE ANTONIO; ORTIZ D'AVILA ASSUMPACAO, MAYRA ELENA. System for evaluation of oxidative stress on in-vitro-produced bovine embryos. Reproductive BioMedicine Online, v. 31, n. 4, p. 577-580, OCT 2015. Web of Science Citations: 8.