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Development of chemically modified electrodes for the voltammetric determination of cocaine, MDMA, LSD, and D-9-tetrahydrocannabinol in samples of forensic interest


This project aims the research and development of transducers for the voltammetric determination of cocaine, MDMA (the main psychoactive component of ecstasy), LSD and D-9-tetrahydrocannabinol (the main psychoactive component of marijuana) in samples of narcotics seized by the police. Considering the fact that all these species show electrochemical response by chemical oxidation or reduction in conventional electrode surface (solid electrodes or Hg without chemical modification of surface), this project proposes the chemical modification of electrode surface by thin films, using electrodeposition, dip coating or spin coating processes. As surface modifiers, fourteen Schiff bases will be used (Salen and Salcn structures) with different cations anchored at them (Co, Fe, Cu, Ni, V and U), and will be investigated also three species of cucurbiturils. Improved selectivity and chemical specificity are expected with these surface modifications, as well as an increase in the amperometric sensitivity for these analytes. In the subsequent step, the chemical films that present the best results in terms of selectivity and specificity should be used in two different fronts, namely: 1) surface modification of screen printed electrodes, in order to obtain portable devices for application in field; 2) surface modification of the electrode of flow electrochemical cell detector of the HPLC equipment, for laboratory analysis. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARCO A. BALBINO; IZABEL C. ELEOTÉRIO; LAURA S. DE OLIVEIRA; MATHEUS M. T. DE MENEZES; JOSÉ FERNANDO DE ANDRADE; ANTÔNIO JOSÉ IPÓLITO; MARCELO F. DE OLIVEIRA. A comparative study between two different conventional working electrodes for detection of Δ9-tetrahydrocannabinol using square-wave voltammetry: a new sensitive method for forensic analysis. Journal of the Brazilian Chemical Society, v. 25, n. 3, p. 589-596, . (12/00084-7)
TADINI, MARAINE CATARINA; BALBINO, MARCO ANTONIO; ELEOTERIO, IZABEL CRISTINA; DE OLIVEIRA, LAURA SIQUEIRA; DIAS, LUIS GUSTAVO; DEMETS, GREGOIRE JEAN-FRANCOIS; DE OLIVEIRA, MARCELO FIRMINO. Developing electrodes chemically modified with cucurbit[6]uril to detect 3,4-methylenedioxymethamphetamine (MDMA) by voltammetry. Electrochimica Acta, v. 121, p. 188-193, . (12/17602-0, 12/00084-7)
MUZETTI RIBEIRO, MARIA FERNANDA; DA CRUZ JUNIOR, JOSE WILMO; DOCKAL, EDWARD RALPH; MCCORD, BRUCE ROYSTON; DE OLIVEIRA, MARCELO FIRMINO. Voltammetric Determination of Cocaine Using Carbon Screen Printed Electrodes Chemically Modified with Uranyl Schiff Base Films. Electroanalysis, v. 28, n. 2, p. 320-326, . (12/00084-7, 13/17630-7)
BALBINO, MARCO A.; ELEOTERIO, IZABEL C.; DE OLIVEIRA, LAURA S.; DE MENEZES, MATHEUS M. T.; DE ANDRADE, JOSE FERNANDO; IPOLITO, ANTONIO JOSE; DE OLIVEIRA, MARCELO F.. A Comparative Study Between Two Different Conventional Working Electrodes for Detection of Delta(9)-Tetrahydrocannabinol Using Square-Wave Voltammetry: a New Sensitive Method for Forensic Analysis. Journal of the Brazilian Chemical Society, v. 25, n. 3, p. 589-596, . (12/00084-7)
DE OLIVEIRA, LAURA SIQUEIRA; DOS SANTOS POLES, ANA PAULA; BALBINO, MARCO ANTONIO; TELES DE MENEZES, MATHEUS MANOEL; DE ANDRADE, JOSE FERNANDO; DOCKAL, EDWARD RALPH; TRISTAO, HELOISA MARIA; DE OLIVEIRA, MARCELO FIRMINO. Voltammetric Determination of Cocaine in Confiscated Samples Using a Carbon Paste Electrode Modified with Different [UO2(X-MeOsalen)(H2O)]center dot H2O Complexes. SENSORS, v. 13, n. 6, p. 7668-7679, . (12/00084-7)
BALBINO, MARCO A.; DE OLIVEIRA, LAURA S.; ELEOTERIO, IZABEL C.; OIYE, ERICA N.; RIBEIRO, MARIA F. M.; MCCORD, BRUCE R.; IPOLITO, ANTONIO J.; DE OLIVEIRA, MARCELO F.. The Application of Voltammetric Analysis of Delta(9)-THC for the Reduction of False Positive Results in the Analysis of Suspected Marijuana Plant Matter. JOURNAL OF FORENSIC SCIENCES, v. 61, n. 4, p. 1067-1073, . (12/00084-7)

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