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Phthalocyanines as photosensitizers in photodynamic therapy

Grant number: 11/22561-9
Support type:Regular Research Grants
Duration: May 01, 2012 - April 30, 2014
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal Investigator:Anderson Orzari Ribeiro
Grantee:Anderson Orzari Ribeiro
Home Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil


The main objective of this project is to obtain, characterize and assess the photochemical, photophysical and phototherapeutic properties of new phthalocyanines derivatives for use as photosensitizers in photodynamic therapy. The project proposes the synthesis and characterization of new symmetrical and asymmetrical phthalocyanines linked to different peripheral groups, such as carbohydrates and polyols, chiral compounds and substituents with positive and negative charges, always aiming to give the macrocycle a set of properties suitable for use in photodynamic therapy. It is expected that the presence of a combination of these peripheral groups around the phthalocyanines macrociclic may provide greater solubility in physiological media, decreased of aggregation process (due to the stereochemistry of the link), and also a greater interaction and selectivity to cancer cells, potentiating these new compounds for use as a photosensitizer. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RAMOS, ALINE A.; NASCIMENTO, FRANCISCO B.; DE SOUZA, THAIZA F. M.; OMORI, ALVARO T.; MANIERI, TANIA M.; CERCHIARO, GISELLE; RIBEIRO, ANDERSON O. Photochemical and Photophysical Properties of Phthalocyanines Modified with Optically Active Alcohols. Molecules, v. 20, n. 8, p. 13575-13590, AUG 2015. Web of Science Citations: 9.
DO NASCIMENTO, F. B.; MANIERI, T. M.; CERCHIARO, G.; RIBEIRO, A. O. Synthesis of unsymmetrical phthalocyanine derivatives and their interaction with mammary MCF7 cells. DYES AND PIGMENTS, v. 99, n. 2, p. 316-322, NOV 2013. Web of Science Citations: 10.

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