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Apoptosis in human salivary glands: evaluation of markers during the morphogenesis and tumorigenesis of human salivary glands using pleomorphic adenoma and mucoepidermoid carcinoma as models

Grant number: 11/02051-6
Support type:Research Grants - Young Investigators Grants
Duration: July 01, 2012 - December 31, 2016
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Cláudia Malheiros Coutinho Camillo
Grantee:Cláudia Malheiros Coutinho Camillo
Home Institution: A C Camargo Cancer Center. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil
Assoc. researchers:Fernando Augusto Soares ; Luiz Paulo Kowalski ; Maria Aparecida Nagai ; Silvia Vanessa Lourenço
Associated grant(s):16/25952-2 - Gordon Research Conference on Salivary Glands and Exocrine Biology , AR.EXT
Associated scholarship(s):12/09759-7 - Apoptosis in human salivary glands: evaluation of markers during the morphogenesis and tumorigenesis of human salivary glands using pleomorphic adenoma and mucoepidermoid carcinoma as models, BP.JP

Abstract

Salivary glands are complex structures formed by a system of ducts and acini. During salivary gland morphogenesis, the formation of the salivary gland involves coordination of morphogenetic mechanisms, including regulated cell shape changes and gene expression, and directed cell migration leading to a fully developed gland with important secretory functions. Understanding the mechanisms of glandular morphogenesis may be important to comprehend the tumorigenic process of salivary gland and their different neoplasms. Apoptosis is one of the major processes involved in lumen formation during morphogenesis of glandular structures, including salivary gland development. Salivary glands neoplasms represent a diverse group of tumors with different characteristics. In several occasions, differential diagnosis of these lesions is difficult. These difficulties motivate the search for prognostic/diagnostic molecular markers in order to improve accuracy. In this study, we will investigate the relationship between mucin and phenotipic markers expression and apoptotic events during salivary gland branching morphogenesis by using immunohistochemistry, immunofluorescence and 3D cell culture. We will also study the expression of proteins related to apoptosis in salivary gland tumors by using immunohistochemistry and immunofluorescence and we will also study the expression of apoptosis-related miRNAs by using Real Time RT-PCR. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, GABRIELA M.; SAAVEDRA, VICTORIA; IANEZ, RENATA C. F.; DE SOUSA, ELEN A.; GOMES, AGATHA N.; KELNER, NATALIE; NAGAI, MARIA A.; KOWALSKI, LUIZ P.; SOARES, FERNANDO A.; LOURENCO, SILVIA V.; COUTINHO-CAMILLO, CLAUDIA M. Apoptotic signaling in salivary mucoepidermoid carcinoma. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v. 41, n. 9, p. 2904-2913, SEP 2019. Web of Science Citations: 0.
DE MELLO GOMES, AGATHA NAGLI; NAGAI, MARIA APARECIDA; LOURENCO, SILVIA VANESSA; COUTINHO-CAMILLO, CLAUDIA MALHEIROS. Apoptosis and proliferation during human salivary gland development. Journal of Anatomy, v. 234, n. 6, p. 830-838, JUN 2019. Web of Science Citations: 0.
DE CAMPOS PARRA FLORES, BIANCA DE CASSIA TRONCARELLI; LOURENCO, SILVIA VANESSA; DAMASCENA, ALINE SANTOS; KOWASLKI, LUIZ PAULO; SOARES, FERNANDO AUGUSTO; COUTINHO-CAMILLO, CLAUDIA MALHEIROS. Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis. Virchows Archiv, v. 470, n. 3, p. 291-299, MAR 2017. Web of Science Citations: 3.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
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