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Evaluation of the SERCA2a role in left ventricle diastolic dysfunction in rats submitted to supravalvar aortic stenosis

Grant number: 11/21366-8
Support type:Regular Research Grants
Duration: July 01, 2012 - June 30, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Antonio Carlos Cicogna
Grantee:Antonio Carlos Cicogna
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Under pressure overload conditions, the heart undergoes an adaptative process of cardiac remodelation (CR). Among the forms that it presents itself, ventricular hypertrophy stands out. It determines, initially, an improvement in sytolic function, searching cardiac stability maintenance. However, in the longterm picture, CR represents a risk factor for ventricular dysfunction and heart faillure. Among the experimental models available for the study of the effects of pressure overload, supravalvar aortic stenosis stands out for, due to is progressive nature, being the most similar to the equivalent condition in the human being. In this model, several autors have detected diastolic dysfunction in 6 weeks rats. Others have also found a reduction on the protein expression of SERCA2a. However, no study has stablished an objective relationship between the SERCA2a decrease and the drop on the diastolic performance. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MAZETO, I. F. S.; OKOSHI, K.; SILVEIRA, C. F. S. M. P.; SANT'ANA, P. G.; DA SILVA, V. L.; MOTA, G. A. F.; DE SOUZA, S. L. B.; VILEIGAS, D. F.; PADOVANI, C. R.; CICOGNA, A. C. Calcium homeostasis behavior and cardiac function on left ventricular remodeling by pressure overload. Brazilian Journal of Medical and Biological Research, v. 54, n. 4 2021. Web of Science Citations: 0.

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