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Evaluation of the intensity of inflammation caused by chemical castration with zinc gluconate and the analgesia provided by Dipyrone, Tramadol and Meloxicam in this procedure

Grant number: 12/04368-0
Support type:Regular Research Grants
Duration: June 01, 2012 - May 31, 2013
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:Denise Tabacchi Fantoni
Grantee:Denise Tabacchi Fantoni
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Thaís Colombo Rossetto

Abstract

The uncontrolled increase in the dogs`s population is an important issue of public health and animal welfare. The risk of transmission of zoonoses, abandonments, road kill, malnutrition and ill-treatment demonstrate the need to study techniques and mechanisms of population control canine. In March 2009, the company Rhobifarma Pharmaceutical Industries Ltd. launched in Brazil the Infertile ®, an injectable solution of zinc gluconate. A promising substance for chemical sterilization of dogs, considered non-carcinogenic, non-teratogenic and non-mutagenic agent, and with low cost. Despite the evolution of methods of sterilization, the literature is poor regarding the assessment of inflammation and pain of these. It is known that the clinical measurement of pain is a challenge to researchers, considering the subjectivity, complexity and multidimensionality of the pain experience. This study aims to evaluate and compare the level of pain and inflammation that chemical sterilization by zinc gluconate can provide. For this, we used 34 healthy dogs, males randomly assigned to four groups. Group D will receive dipyrone (25 mg/kg IM), the animals of group T will receive tramadol (2mg/kg IM), the animals in group M receive meloxicam (0.2 mg / kg IM) and these drugs are given 15 minutes before application of the zinc gluconate. The fourth group of animals will be subjected to anesthesia and surgical orchiectomy. Will be assessed for heart rate, respiratory rate, diameter of the testes, and rectal temperature of the testes, serum cortisol, epinephrine, norepinephrine, interleukin plasma glucose levels and analgesia by visual analog scale (VAS), descriptive scale thermo algimetry, Glasgow scale and scale of the State University of Colorado. Data will be analyzed statistically in order to compare the groups together and the different evaluations of the same group. The animals should be observed for seven days. (AU)