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Modulation of interleukin 17b and 25 activity associated with melatonin as inductor of apoptosis in cell culture of mammary neoplasms

Grant number: 12/06098-0
Support type:Regular Research Grants
Duration: June 01, 2012 - May 31, 2014
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Debora Aparecida Pires de Campos Zuccari
Grantee:Debora Aparecida Pires de Campos Zuccari
Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil

Abstract

Cytokines are intercellular mediators which regulate survival, differentiation and effector functions of cells and has been proven to be related to cancer. Some of them have definite activity, but the understanding of its interaction with the genesis and tumor progression may contribute to the success of preventive and therapeutic protocols. The IL-25 is known for its role in the immune response and it is known that the interaction with its receptor IL-25R induces apoptosis. Little is known about this interaction, only that there is competition for the site of action with IL-17B in neoplastic cells, contributing to tumor progression in these cells. It has been proposed that melatonin may protect normal cells from apoptosis, and conversely, induce it in neoplastic cells. The objective of this study is to control tumor growth through increased apoptosis as a therapeutic strategy in breast neoplasms. Treatment will be performed with IL-25 with or without melatonin and the silencing of IL-17B and human cell lines and primary cultures of canine mammary neoplasms of different grades of malignancy of dogs, with emphasis on inflammatory carcinomas. These results could allow the use of interleukins associated or not with melatonin as therapeutic agents in breast cancer. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GELALETI, G. B.; BORIN, T. F.; MASCHIO-SIGNORINI, L. B.; MOSCHETTA, M. G.; HELLMEN, E.; VILORIA-PETIT, A. M.; ZUCCARI, D. A. P. C. Melatonin and IL-25 modulate apoptosis and angiogenesis mediators in metastatic (CF-41) and non-metastatic (CMT-U229) canine mammary tumour cells. VETERINARY AND COMPARATIVE ONCOLOGY, v. 15, n. 4, p. 1572-1584, DEC 2017. Web of Science Citations: 2.
GELALETI, GABRIELA BOTTARO; BONIN, THAIZ FERRAZ; MASCHIO-SIGNORINI, LARISSA BAZELA; MOSCHETTA, MARINA GOBBE; JARDIM-PERASSI, BRUNA VICTORASSO; CALVINHO, GUILHERME BERTO; FACCHINI, MARIANA CASTILHO; VILORIA-PETIT, ALICIA M.; PIRES DE CAMPOS ZUCCARI, DEBORA APARECIDA. Efficacy of melatonin, IL-25 and siIL-17B in tumorigenesis-associated properties of breast cancer cell lines. Life Sciences, v. 183, p. 98-109, AUG 15 2017. Web of Science Citations: 7.
MARTINS, GUSTAVO RODRIGUES; GELALETI, GABRIELA BOTTARO; MOSCHETTA, MARINA GOBBE; MASCHIO-SIGNORINI, LARISSA BAZELA; PIRES DE CAMPOS ZUCCARI, DEBORA AP. Proinflammatory and Anti-Inflammatory Cytokines Mediated by NF-kappa B Factor as Prognostic Markers in Mammary Tumors. Mediators of Inflammation, 2016. Web of Science Citations: 12.

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