New cellular, molecular and immunological mechanisms involved in acute and chronic renal injury: the search for new therapeutical approaches

• Grant number: 12/02270-2
• Support Opportunities: Research Projects - Thematic Grants
• Start date: July 01, 2012
• End date: June 30, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Niels Olsen Saraiva Câmara
• Grantee: Niels Olsen Saraiva Câmara
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais: Patricia Chakur Brum ; Roberto Zatz ; Ronaldo de Carvalho Araújo
• Associated researchers: Alvaro Pacheco e Silva Filho ; Andrea Cecilia Dorión Rodas ; Andréa Moro Caricilli Blotta ; Clarice Kazue Fujihara ; Daniela Carlos Sartori ; Denise Maria Avancini Costa Malheiros ; Jean Pierre Schatzmann Peron ; João Santana da Silva ; Lucia da Conceição Andrade ; Maisa Splendore Della Casa ; Marcelo Alves da Silva Mori ; Marco Aurélio Ramirez Vinolo ; Mariane Tami Amano ; Maristella de Almeida Vitta Landgraf ; MILTON ROCHA DE MORAES ; Patricia Chakur Brum ; Patricia Semedo Kuriki ; Rosa Maria Elias ; Rui Curi ; William Tadeu Lara Festuccia
• Associated research grant(s): 12/13134-2 - European congress of immunology, AR.EXT
• Associated scholarship(s): 17/05687-5 - Influence of microbiota on the role of macrophages during acute renal injury induced by cisplatin in zebrafish, BP.MS; 16/02299-1 - AMPK signaling pathway in T CD4 lymphocytes and macrophages in the progression of experimental chronic kidney disease, BP.MS; 15/15062-7 - Role of AMPK pathway in the modulation of anti-tumor immune response by T lymphocytes (CD4 and CD8), BP.DR; + associated scholarships 15/26620-0 - Activation and regulation of B cells and their metabolic pathways in experimental organ transplantation, BP.MS; 15/26682-6 - Evaluation of mTOR on energy metabolism and activation of B cells during experimental intestinal inflammation, BP.DR; 15/21644-9 - Obesity-induced inflammation, alterations in the microbiota and their effects on the enteric nervous system: study in an experimental model of zebrafish., BP.DR; 14/10910-7 - mTOR signaling pathway in neutrophils during inflammation experimental model associated with obesity, BP.DR; 15/18121-4 - Relationship between obesity and intestinal lamina propria cells function in insulin resistance development, BP.PD; 14/21005-3 - Skeletal muscle repair in response to eccentric exercise-induced muscle damage: STAT3 signaling pathway on proliferation and differentiation of satellite cells, BP.PD; 14/14147-6 - Role of obesity in model of allogeneic transplant rejection, BP.IC; 14/07390-1 - Mesenchymal stromal cells derived microvesicles as inductors of immune tolerance, BP.DR; 14/09450-1 - Influence of intestinal microbiota in the subtypes dendritic cells activation in acute colitis ulcerative model, BP.DR; 14/06992-8 - Cellular, molecular and immunological mechanisms generated through NLRP activation, BP.PD; 14/02912-0 - Evaluation of the protective effect of mesenchymal stem cells-derived microvesicles in in vivo and in vitro models of chronic kidney injury, BP.IC; 14/06991-1 - Pathogenic role of mast cells in tubulointerstitial fibrosis development in chronic kidney disease, BP.PD; 13/25327-2 - Role of inflammatory microenvironment in activation and biology of mesenchymal stem cells, BP.PD; 13/25010-9 - Role of heme oxygenase-1 in autophagy modulation during ischemic renal injury, BP.PD; 13/11712-1 - Platelet involvement during injury and remodeling after experimental acute and chronic kidney insults, BP.PD; 13/10318-8 - Immunobiological actions of adipokines in experimental murine model of melanoma., BP.PD; 12/23347-3 - Role of Adiponectin and Obesity in the Rejection of Allogeneic Transplants., BP.DR; 12/15789-6 - Effects of Resistance Exercise Training in mechanisms cellular stress response and in the process of autophagy in experimental chronic kidney disease., BP.PD; 12/16794-3 - Influence of gut microbiota on NKT cells profile in an experimental model of colitis, BP.DR; 12/15205-4 - Role of short chain fatty acids on experimental focal and segmental glomerulosclerosis, BP.DD; 12/10435-1 - THE INFLUENCE OF MTOR PATHWAY IN MACROPHAGE MODULATION AND ITS CONSEQUENCES IN EXPERIMENTAL CHRONIC KIDNEY DISEASE, BP.PD - associated scholarships

Abstract

In recent years, several research groups in Brazil and abroad, including ours, have consistently shown the role of the inflammatory response in some kidney diseases. Despite the advances have been most prominent in animal models, the strongly generated data indicate that acute and chronic renal lesions are influenced by the immune response, up to now considered sterile in all compartments of the nephron. Now considered an epidemic, renal diseases have enormous social and economic impact with high morbidity and mortality for patients. Thus, acquisition of new knowledge will strengthen the knowledge about the pathogenesis of these diseases, and discovery of new strategies to improve renal dysfunction become necessary to improve patient survival. Specifically, the results obtained by our group in these years show that both components of the innate immune response, such as endothelial cells, cyclooxygenase, bradykinin, and the elements of the adaptive immune response, such as CD4 + T lymphocytes, receptors of innate immunity (like Toll like receptors and Nod-like) and cells participate as effectors of renal injury. We also saw that early after the begging of an inflammatory response, the renal tissue is able to mount a cytoprotective response ranging from a reorganization of the expression of proteins in the endoplasmic reticulum to the action of HO-1. More recently, new molecules, hormones and cell subsets were identified and shown to participate in various inflammatory diseases. With changes in lifestyle, new factors were added to the list of co-morbidities renal diseases such as obesity. Along with these, new adipogenicity related hormones; changes in intestinal microflora and inflammatory molecules have been given an important role in the pathogenesis of renal injury. In this project, we intend to further study the participation of the inflammatory response in renal lesions, with a current text, taking into account new molecules, lymphocyte/macrophages subsets and molecules with new functions in different models of acute and chronic kidney injury and models of cell injury "in vitro". We intend to respond to a working hypothesis and objectives. (AU)

Scientific publications

(53)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CORREA-COSTA, MATHEUS; BRAGA, TARCIO TEODORO; FELIZARDO, RAPHAEL JOSE FERREIRA; ANDRADE-OLIVEIRA, VINICIUS; REGINA PEREZ, KATIA; MIDEA CUCCOVIA, IOLANDA; IOSHIE HIYANE, MEIRE; SANTANA DA SILVA, JOAO; SARAIVA CAMARA, NIELS OLSEN. Macrophage Trafficking as Key Mediator of Adenine-Induced Kidney Injury. Mediators of Inflammation, 2014. (13/25010-9, 12/02270-2)

AMANO, MARIANE T.; CASTOLDI, ANGELA; ANDRADE-OLIVEIRA, VINICIUS; LATANCIA, MARCELA T.; TERRA, FERNANDA F.; CORREA-COSTA, MATHEUS; BREDA, CRISTIANE N. S.; FELIZARDO, RAPHAEL J. F.; PEREIRA, WELBERT O.; DA SILVA, MARINA B.; et al. The lack of PI3K gamma favors M1 macrophage polarization and does not prevent kidney diseases progression. International Immunopharmacology, v. 64, p. 151-161, NOV 2018. (12/02270-2, 13/09563-8, 12/10435-1)

SOUZA, MICHEL KENDY; MORAES, MILTON ROCHA; ROSA, THIAGO SANTOS; PASSOS, CLEVIA SANTOS; PASSOS NEVES, RODRIGO VANERSON; HARO, ANDERSON SOLA; CENEDEZE, MARCOS ANTONIO; ALARCON ARIAS, SIMONE COSTA; FUJIHARA, CLARICE KAZUE; TEIXEIRA, SIMONE APARECIDA; et al. L-Arginine supplementation blunts resistance exercise improvement in rats with chronic kidney disease. Life Sciences, v. 232, SEP 1 2019. (17/05264-7, 12/02270-2)

DE SOUZA, JEAN GABRIEL; MORAIS, KATIA L. P.; ANGLES-CANO, EDUARDO; BOUFLEUR, PAMELA; DE MELLO, EVANDRO SOBROZA; MARIA, DURVANEI AUGUSTO; TAEMI ORIGASSA, CLARICE SILVIA; ZAMPOLLI, HAMILTON DE CAMPOS; SARAIVA CAMARA, NIELS OLSEN; BERRA, CAROLINA MARIA; et al. Promising pharmacological profile of a Kunitz-type inhibitor in murine renal cell carcinoma model. ONCOTARGET, v. 7, n. 38, p. 62255-62266, SEP 20 2016. (13/07467-1, 15/50040-4, 12/02270-2, 12/06944-8, 10/07958-7)

PASCHOAL, VIVIAN A.; AMANO, MARIANE T.; BELCHIOR, THIAGO; MAGDALON, JULIANA; CHIMIN, PATRICIA; ANDRADE, MAYNARA L.; ORTIZ-SILVA, MILENE; CASTRO, ERIQUE; YAMASHITA, ALEX S.; ROSA NETO, JOSE CESAR; et al. mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function. Immunobiology, v. 222, n. 2, p. 261-271, FEB 2017. (15/19530-5, 12/02270-2, 11/10783-7, 09/15354-7)

DE ALMEIDA, DANILO CANDIDO; BASSI, ENIO JOSE; AZEVEDO, HATYLAS; ANDERSON, LETICIA; TAEMI ORIGASSA, CLARICE SILVIA; CENEDEZE, MARCOS ANTONIO; DE ANDRADE-OLIVEIRA, VINICIUS; FERREIRA FELIZARDO, RAPHAEL JOSE; DA SILVA, REINALDO CORREIA; HIYANE, MEIRE IOSHIE; et al. A Regulatory miRNA-mRNA Network Is Associated with Tissue Repair Induced by Mesenchymal Stromal Cells in Acute Kidney Injury. FRONTIERS IN IMMUNOLOGY, v. 7, JAN 3 2017. (12/02270-2)

BURGOS-SILVA, MARINA; SEMEDO-KURIKI, PATRICIA; DONIZETTI-OLIVEIRA, CASSIANO; COSTA, PRISCILLA BARBOSA; CENEDEZE, MARCO ANTONIO; HIYANE, MEIRE IOSHIE; PACHECO-SILVA, ALVARO; SARAIVA CAMARA, NIELS OLSEN. Adipose Tissue-Derived Stem Cells Reduce Acute and Chronic Kidney Damage in Mice. PLoS One, v. 10, n. 11, NOV 13 2015. (12/02270-2)

SOUZA, MICHEL KENDY; PASSOS NEVES, RODRIGO VANERSON; ROSA, THIAGO SANTOS; CENEDEZE, MARCOS ANTONIO; ARIAS, SIMONE COSTA A.; FUJIHARA, CLARICE KAZUE; PEREIRA BACURAU, REURY FRANK; SARAIVA CAMARA, NIELS OLSEN; MORAES, MILTON ROCHA; PACHECO E SILVA FILHO, ALVARO. Resistance training attenuates inflammation and the progression of renal fibrosis in chronic renal disease. Life Sciences, v. 206, p. 93-97, AUG 1 2018. (12/02270-2)

IGNACIO, ALINE; SOUZA BREDA, CRISTIANE NAFFAH; SARAIVA CAMARA, NIELS OLSEN. Innate lymphoid cells in tissue homeostasis and diseases. WORLD JOURNAL OF HEPATOLOGY, v. 9, n. 23, p. 979-989, AUG 18 2017. (12/02270-2)

IGNACIO, ALINE; MORALES, CAMILA IDELI; SARAIVA CAMARA, NIELS OLSEN; ALMEIDA, RAFAEL RIBEIRO. Innate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseases. FRONTIERS IN IMMUNOLOGY, v. 7, FEB 19 2016. (12/02270-2)

DA SILVA, REGINA P.; ZAMPIERI, THAIS T.; PEDROSO, JOAO A. B.; NAGAISHI, VANESSA S.; RAMOS-LOBO, ANGELA M.; FURIGO, ISADORA C.; CAMARA, NIELS O.; FRAZAO, RENATA; DONATO, JR., JOSE. Leptin Resistance Is Not the Primary Cause of Weight Gain Associated With Reduced Sex Hormone Levels in Female Mice. Endocrinology, v. 155, n. 11, p. 4226-4236, NOV 2014. (13/00801-3, 10/18086-0, 12/12202-4, 13/16374-7, 12/02270-2, 12/15517-6, 13/21722-4)

KORKES, HENRI AUGUSTO; SASS, NELSON; MORON, ANTONIO F.; CAMARA, NIELS OLSEN S.; BONETTI, TATIANA; CERDEIRA, ANA SOFIA; COTRIM GUERREIRO DA SILVA, ISMAEL DALE; DE OLIVEIRA, LEANDRO. Lipidomic Assessment of Plasma and Placenta of Women with Early-Onset Preeclampsia. PLoS One, v. 9, n. 10, OCT 17 2014. (12/02270-2)

CORREA-COSTA, MATHEUS; ANDRADE-OLIVEIRA, VINICIUS; BRAGA, TARCIO T.; CASTOLDI, ANGELA; AGUIAR, CRISTHIANE F.; ORIGASSA, CLARICE S. T.; RODAS, ANDREA C. D.; HIYANE, MEIRE I.; MALHEIROS, DENISE M. A. C.; RIOS, FRANCISCO J. O.; et al. Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis. LABORATORY INVESTIGATION, v. 94, n. 4, p. 455-466, APR 2014. (12/02270-2)

BARBOZA, RENATO; REIS, ARAMYS SILVA; DA SILVA, LEANDRO GUSTAVO; HASENKAMP, LUTERO; BENEVIDES PEREIRA, KEITTY RAQUEL; SARAIVA CAMARA, NIELS OLSEN; MARANHAO COSTA, FABIO TRINDADE; D'IMPERIO LIMA, MARIA REGINA; ALVAREZ, JOSE MARIA; BOSCARDIN, SILVIA BEATRIZ; et al. MyD88 Signaling Is Directly Involved in the Development of Murine Placental Malaria. Infection and Immunity, v. 82, n. 2, p. 830-838, FEB 2014. (09/53256-7, 11/17880-8, 12/02270-2, 09/53889-0)

MORAES-VIEIRA, P. M. M.; BASSI, E. J.; ARAUJO, R. C.; CAMARA, N. O. S.. Leptin as a link between the immune system and kidney-related diseases: leading actor or just a coadjuvant?. Obesity Reviews, v. 13, n. 8, p. 733-743, AUG 2012. (07/07139-3, 12/02270-2, 09/50450-7)

LANDGRAF, MARISTELLA A.; LANDGRAF, RICHARDT G.; SILVA, REINALDO C.; SEMEDO, PATRICIA; CAMARA, NIELS O. S.; FORTES, ZULEICA B.. Intrauterine Undernourishment Alters TH1/TH2 Cytokine Balance and Attenuates Lung Allergic Inflammation in Wistar Rats. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 30, n. 3, p. 552-562, 2012. (07/07139-3, 12/02270-2, 10/01404-0, 09/09849-3)

LANDGRAF, MARISTELLA A.; SILVA, REINALDO C.; CORREA-COSTA, MATHEUS; HIYANE, MEIRE I.; CARVALHO, MARIA HELENA C.; LANDGRAF, RICHARDT G.; CAMARA, NIELS O. S.. Leptin Downregulates LPS-Induced Lung Injury: Role of Corticosterone and Insulin. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 33, n. 3, p. 835-846, 2014. (12/10512-6, 12/51104-8, 12/02270-2, 10/01404-0)

LAROCCA, RAFAEL ASSUMPCAO; MORAES-VIEIRA, PEDRO MANOEL; BASSI, ENIO JOSE; SEMEDO, PATRICIA; DE ALMEIDA, DANILO CANDIDO; DA SILVA, MARINA BURGOS; THORNLEY, THOMAS; PACHECO-SILVA, ALVARO; SARAIVA CAMARA, NIELS OLSEN. Adipose Tissue-Derived Mesenchymal Stem Cells Increase Skin Allograft Survival and Inhibit Th-17 Immune Response. PLoS One, v. 8, n. 10, OCT 4 2013. (07/07139-3, 12/02270-2, 06/55326-4)

ELIAS, ROSA MARIA; CORREA-COSTA, MATHEUS; BARRETO, CLAUDIENE RODRIGUES; SILVA, REINALDO CORREIA; HAYASHIDA, CAROLINE Y.; CASTOLDI, ANGELA; GONCALVES, GISELLE MARTINS; BRAGA, TARCIO TEODORO; BARBOZA, RENATO; RIOS, FRANCISCO JOSE; et al. Oxidative Stress and Modification of Renal Vascular Permeability Are Associated with Acute Kidney Injury during P. berghei ANKA Infection. PLoS One, v. 7, n. 8, AUG 31 2012. (07/07139-3, 12/02270-2)

MORAES-VIEIRA, P. M. M.; BASSI, E. J.; LAROCCA, R. A.; CASTOLDI, A.; BURGHOS, M.; LEPIQUE, A. P.; QUINTANA, F. J.; ARAUJO, R. C.; BASSO, A. S.; STROM, T. B.; et al. Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile. AMERICAN JOURNAL OF TRANSPLANTATION, v. 13, n. 1, p. 36-44, JAN 2013. (07/07139-3, 12/02270-2, 09/50450-7, 08/58564-9)

CASTOLDI, ANGELA; DE AGUIAR, CRISTHIANE FAVERO; MORAES-VIEIRA, PEDRO MANOEL; SARAIVA CAMARA, NIELS OLSEN. They Must Hold Tight: Junction Proteins, Microbiota And Immunity In Intestinal Mucosa. CURRENT PROTEIN & PEPTIDE SCIENCE, v. 16, n. 7, p. 655-671, 2015. (14/10828-9, 12/02270-2, 12/16794-3, 14/02218-6, 11/15682-4)

CASTOLDI, ANGELA; ANDRADE-OLIVEIRA, VINICIUS; AGUIAR, CRISTHIANE FAVERO; AMANO, MARIANE TAMI; LEE, JENNIFER; MIYAGI, MARCELLI TERUMI; LATANCIA, MARCELA TEATIN; BRAGA, TARCIO TEODORO; DA SILVA, MARINA BURGOS; IGNACIO, ALINE; et al. Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88. CELL REPORTS, v. 19, n. 11, p. 2272-2288, JUN 13 2017. (15/18121-4, 11/15682-4, 12/02270-2)

FELIZARDO, R. J. F.; WATANABE, I. K. M.; DARDI, PATRIZIA; ROSSONI, L. V.; CAMARA, N. O. S.. The interplay among gut microbiota, hypertension and kidney diseases: The role of short-chain fatty acids. PHARMACOLOGICAL RESEARCH, v. 141, p. 366-377, MAR 2019. (12/15205-4, 17/06222-6, 17/05264-7, 12/02270-2, 16/08907-3)

PASCHOAL, VIVIAN A.; BELCHIOR, THIAGO; AMANO, MARIANE T.; BURGOS-SILVA, MARINA; PEIXOTO, ALBERT S.; MAGDALON, JULIANA; VIEIRA, THAYNA S.; ANDRADE, MAYNARA L.; MORENO, MAYARA F.; CHIMIN, PATRICIA; et al. Constitutive Activation of the Nutrient Sensor mTORC1 in Myeloid Cells Induced by Tsc1 Deletion Protects Mice from Diet-Induced Obesity. MOLECULAR NUTRITION & FOOD RESEARCH, v. 62, n. 17, SEP 2018. (15/19530-5, 12/02270-2, 11/10783-7, 09/15354-7)

FELIZARDO, RAPHAEL J. F.; DE ALMEIDA, DANILO C.; PEREIRA, RAFAEL L.; WATANABE, INGRID K. M.; DOIMO, NAYARA T. S.; RIBEIRO, WILLIAN R.; CENEDEZE, MARCOS A.; HIYANE, MEIRE I.; AMANO, MARIANE T.; BRAGA, TARCIO T.; et al. Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms. FASEB JOURNAL, v. 33, n. 11, p. 11894-11908, NOV 2019. (14/13135-4, 12/02270-2, 12/15205-4, 12/50410-8, 17/05264-7)

BRAGA, TARCIO TEODORO; CORREA-COSTA, MATHEUS; SILVA, REINALDO CORREIA; CRUZ, MARIO COSTA; HIYANE, MEIRE IOSHIE; DA SILVA, JOAO SANTANA; PEREZ, KATIA REGINA; CUCCOVIA, IOLANDA MIDEA; SARAIVA CAMARA, NIELS OLSEN. CCR2 contributes to the recruitment of monocytes and leads to kidney inflammation and fibrosis development. INFLAMMOPHARMACOLOGY, v. 26, n. 2, p. 403-411, APR 2018. (14/06992-8, 12/02270-2)

CORREA-COSTA, MATHEUS; BRAGA, TARCIO TEODORO; FELIZARDO, RAPHAEL JOSE FERREIRA; ANDRADE-OLIVEIRA, VINICIUS; REGINA PEREZ, KATIA; MIDEA CUCCOVIA, IOLANDA; IOSHIE HIYANE, MEIRE; SANTANA DA SILVA, JOAO; SARAIVA CAMARA, NIELS OLSEN. Macrophage Trafficking as Key Mediator of Adenine-Induced Kidney Injury. Mediators of Inflammation, v. 2014, p. 12-pg., 2014-01-01. (12/02270-2, 13/25010-9)

ANDRADE-OLIVEIRA, VINCIUS; CAMARA, NIELS O. S.; MORAES-VIEIRA, PEDRO M.. Adipokines as Drug Targets in Diabetes and Underlying Disturbances. JOURNAL OF DIABETES RESEARCH, v. 2015, p. 11-pg., 2015-01-01. (12/02270-2)

ANDRADE-OLIVEIRA, VINCIUS; CAMARA, NIELS O. S.; MORAES-VIEIRA, PEDRO M.. Adipokines as Drug Targets in Diabetes and Underlying Disturbances. JOURNAL OF DIABETES RESEARCH, 2015. (12/02270-2)

PEZATO, ROGERIO; DE ALMEIDA, DANILO CANDIDO; BEZERRA, THIAGO FREIRE; SILVA, FERNANDO DE SA; PEREZ-NOVO, CLAUDINA; GREGORIO, LUIS CARLOS; VOEGELS, RICHARD LOUIS; CAMARA, NIELS OLSEN; BACHERT, CLAUS. Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment. Mediators of Inflammation, 2014. (10/12295-7, 12/02270-2)

ANDRADE-SILVA, MAGAIVER; CENEDEZE, MARCOS ANTONIO; PERANDINI, LUIZ AUGUSTO; FERREIRA FELIZARDO, RAPHAEL JOSE; MIZUNO WATANABE, INGRID KAZUE; HENAO AGUDELO, JUAN SEBASTIAN; CASTOLDI, ANGELA; GONCALVES, GISELLE MARTINS; TAEMI ORIGASSA, CLARICE SILVIA; SEMEDO, PATRICIA; et al. TLR2 and TLR4 play opposite role in autophagy associated with cisplatin-induced acute kidney injury. Clinical Science, v. 132, n. 16, p. 1725-1739, AUG 31 2018. (07/07139-3, 12/02270-2)

BRAGA, TARCIO TEODORO; CORREA-COSTA, MATHEUS; AZEVEDO, HATYLAS; SILVA, REINALDO CORREIA; CRUZ, MARIO COSTA; SOARES ALMEIDA, MAIRA ESTANISLAU; HIYANE, MEIRE IOSHIE; MOREIRA-FILHO, CARLOS ALBERTO; SANTOS, MARINILCE FAGUNDES; PEREZ, KATIA REGINA; et al. Early infiltration of p40IL12(+)CCR7(+)CD11b(+) cells is critical for fibrosis development. IMMUNITY INFLAMMATION AND DISEASE, v. 4, n. 3, p. 300-314, SEP 2016. (12/02270-2)

PINHEIRO, NATHALIA M.; SANTANA, FERNANDA P. R.; ALMEIDA, RAFAEL RIBEIRO; GUERREIRO, MARINA; MARTINS, MILTON A.; CAPERUTO, LUCIANA C.; CAMARA, NIELS O. S.; WENSING, LISLAINE A.; PRADO, VANIA F.; TIBERIO, IOLANDA F. L. C.; et al. Acute lung injury is reduced by the alpha 7nAChR agonist PNU-282987 through changes in the macrophage profile. FASEB JOURNAL, v. 31, n. 1, p. 320-332, JAN 2017. (12/02270-2, 13/02881-4, 14/25689-4)

DE AGUIAR, CRISTHIANE FAVERO; CASTOLDI, ANGELA; AMANO, MARIANE T.; IGNACIO, ALINE; TERRA, FERNANDA FERNANDES; CRUZ, MARIO; FELIZARDO, RAPHAEL J. F.; BRAGA, TARCIO TEODORO; DAVANZO, GUSTAVO GASTAO; GAMBARINI, VICTOR; et al. Fecal IgA Levels and Gut Microbiota Composition Are Regulated by Invariant Natural Killer T Cells. INFLAMMATORY BOWEL DISEASES, v. 26, n. 5, p. 697-708, MAY 2020. (12/16794-3, 12/02270-2, 17/12848-5)

SAITO MIYAGI, MARIANA YASUE; LATANCIA, MARCELA TEATIN; TESTAGROSSA, LEONARDO ABREU; DE ANDRADE-OLIVEIRA, VINICIUS; PEREIRA, WELBERT OLIVEIRA; HIYANE, MEIRE IOSHIE; ENJIU, LUCAS MACERATESI; PISCIOTTANO, MARCUS; LEITE SEELAENDER, MARILIA CERQUEIRA; SARAIVA CAMARA, NIELS OLSEN; et al. Physical exercise contributes to cisplatin-induced nephrotoxicity protection with decreased CD4+T cells activation. Molecular Immunology, v. 101, p. 507-513, SEP 2018. (12/50079-0, 11/10349-5, 12/10435-1, 12/02270-2)

DE AGUIAR, CRISTHIANE FAVERO; CASTOLDI, ANGELA; ANDRADE-OLIVEIRA, VINICIUS; IGNACIO, ALINE; DA CUNHA, FLAVIA FRANCO; FERREIRA FELIZARDO, RAPHAEL JOSE; BASSI, ENIO JOSE; SARAIVA CAMARA, NIELS OLSEN; DE ALMEIDA, DANILO CANDIDO. Mesenchymal stromal cells modulate gut inflammation in experimental colitis. INFLAMMOPHARMACOLOGY, v. 26, n. 1, p. 251-260, FEB 2018. (13/25327-2, 12/02270-2, 12/16794-3)

DE OLIVEIRA, DANIEL MAY; LOBATO DE OLIVEIRA, ENEDINA MARIA; RAMIRES FERRARI, MERARI DE FATIMA; SEMEDO, PATRICIA; HIYANE, MEIRE IOSHIE; CENEDEZE, MARCOS ANTONIO; PACHECO-SILVA, ALVARO; SARAIVA CAMARA, NIELS OLSEN; SCHATZMANN PERON, JEAN PIERRE. Simvastatin ameliorates experimental autoimmune encephalomyelitis by inhibiting Th1/Th17 response and cellular infiltration. INFLAMMOPHARMACOLOGY, v. 23, n. 6, p. 343-354, DEC 2015. (07/07139-3, 12/02270-2, 11/18703-2)

AGUIAR, CRISTHIANE FAVERO; NAFFAH-DE-SOUZA, CRISTIANE; CASTOLDI, ANGELA; CORREA-COSTA, MATHEUS; BRAGA, TARCIO T.; NAKA, ERIKA L.; AMANO, MARIANE T.; ABATE, DEBORA T. R. S.; HIYANE, MEIRE I.; CENEDEZE, MARCOS A.; et al. Administration of alpha-Galactosylceramide Improves Adenine-Induced Renal Injury. Molecular Medicine, v. 21, p. 553-562, 2015. (07/07139-3, 12/02270-2, 12/16794-3)

ANDRADE-OLIVEIRA, VINICIUS; AMANO, MARIANE T.; CORREA-COSTA, MATHEUS; CASTOLDI, ANGELA; FELIZARDO, RAPHAEL J. F.; DE ALMEIDA, DANILO C.; BASSI, ENIO J.; MORAES-VIEIRA, PEDRO M.; HIYANE, MEIRE I.; RODAS, ANDREA C. D.; et al. Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, v. 26, n. 8, p. 1877-1888, AUG 2015. (12/02270-2, 11/01016-2)

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