Effects of resistance training in the molecular signalling and tissue remodeling in ovariectomized rats

• Grant number: 11/21607-5
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2012
• End date: June 30, 2014
• Field of knowledge: Biological Sciences - Physiology - Physiology of Effort
• Principal Investigator: Sergio Eduardo de Andrade Perez
• Grantee: Sergio Eduardo de Andrade Perez
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• City of the host institution: São Carlos

Abstract

Increased life expectancy of the elderly population is a worldwide phenomenon. In Brazil, the statistics show that this trend is occurring in a radical and very fast which increases the incidence and duration of menopausal women. However, menopause is associated with increased risk of several deleterious metabolic changes that may impair the quality of life. Studies indicate that women in this condition have reduced skeletal muscle mass and bone mineral mass, increased body fat deposition, changes in lipid profile, increased concentrations of inflammatory markers, reduced oxidative capacity, increased risk of developing insulin resistance and cardiovascular disease. These findings emphasize the importance of researching the effectiveness of non-pharmacological interventions to reverse this deleterious situation, since the hormone replacement therapy has resulted in increased risk of developing cancer. Thus, physical activity is indicated to mitigate these symptoms and the resistance training should be considered. Previous studies of our research group show that resistance training promotes positive remodeling of several tissues and minimizes some of the deleterious effects of estrogen reduction, both in humans and animals. The aim of this project is a better understanding of the molecular physiological mechanisms involved in the response to resistance training in the tissues: bone, skeletal muscle, liver, brain and cardiac in ovariectomized rats with and without hormone replacement therapy. (AU)

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

MARKUS V.C SOUZA; ANDERSON D. S LINO; LEANDRO G. D RUFFONI; MATEUS M. DOMINGOS; MARINA R. BARBOSA; MARIA F C. RODRIGUES; FABIANO C. FERREIRA; LUCIANE M. TOMAZ; GUSTAVO H. R. CANEVAZZI; NATÁLIA S. SILVA; et al. Resistance training and hormone replacement increase MMP-2 activity, quality and quantity of bone in ovariectomized rats. Motriz: rev. educ. fis., v. 23, n. 4, 2017-12-21. (11/21607-5)

BARBOSA, M. R.; SHIGUEMOTO, G. E.; TOMAZ, L. M.; FERREIRA, F. C.; RODRIGUES, M. F. C.; DOMINGUES, M. M.; SOUZA MASTER, M. V. C.; CANEVAZZI, G. H. R.; SILVA-MAGOSSO, N. S.; SELISTRE-DE-ARAUJO, H. S.; et al. Resistance Training and Ovariectomy: Antagonic Effects in Mitochondrial Biogenesis Markers in Rat Skeletal Muscle. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 37, n. 11, p. 841-847, OCT 2016. (11/21607-5)